Popular Trials
Behavioural Intervention
Contrave for Weight Maintenance in Obesity
Recruiting4 awardsPhase 4
Guelph, Ontario
This trial tests if Contrave, a weight-loss pill, helps maintain and further weight loss in obese or overweight adults who have already lost some weight through a diet program. The pill works by reducing hunger and increasing satisfaction with less food. Contrave is a combination of naltrexone and bupropion, developed by Orexigen Therapeutics Inc, and has shown moderate weight loss in previous studies.
Contrave for Post-Bariatric Surgery Weight Management
Recruiting4 awardsPhase 4
Guelph, Ontario
This trial is testing Contrave, a weight management pill, in adults who had bariatric surgery but are struggling with weight loss or regaining weight. The pill helps reduce hunger and increase feelings of fullness. Contrave, a combination of bupropion and naltrexone, was approved for chronic weight management in obese adults and has shown effectiveness in reducing food intake. The study will compare the effects of Contrave combined with usual care to usual care alone.
Antidepressant
Combination Therapies for Depression with Kidney Disease
Recruiting0 awardsPhase 2
Dallas, Texas
This trial is testing two new ways to treat depression in people with chronic kidney disease. One method uses therapy sessions over the phone or internet, and the other uses a medication called bupropion. If one method doesn't work after a certain period, the other is added. The goal is to see if these treatments can improve depression and overall health in these patients. Bupropion is a second-generation antidepressant commonly used to treat depression, including in patients with chronic kidney disease.
Antidepressant
Bupropion for Smoking Relapse
Recruiting2 awardsPhase 4
Minneapolis, Minnesota
This trial will enroll pregnant women who recently quit smoking and want to stay abstinent. They will be given either a placebo or extended-release bupropion, and the effects will be monitored through questionnaires and biological sample analysis.
Antidepressant
Bupropion for Depression
Recruiting2 awardsPhase 4
Bridgewater, New Jersey
This trial tests a new treatment for children with depression. The effectiveness is measured by changes in depression symptoms. Fluoxetine has been shown to be effective in treating major depressive disorder in children and adolescents.
Popular Filters
Phase 3 Trials
Behavioural Intervention
Naltrexone + Bupropion for Binge Eating Disorder and Obesity
Recruiting0 awardsPhase 2 & 3
New Haven, Connecticut
This trial will compare the effectiveness of a combination of naltrexone and bupropion medication to placebo in patients with obesity who have not responded to other treatments for binge-eating disorder.
Zonisamide + Bupropion for Smoking Cessation
Recruiting3 awardsPhase 3
Charlotte, North Carolina
This trial will evaluate the impact of combining zonisamide and bupropion on the process of switching from CCs to an e-cigarette. There will be a data collection period of at least five days to obtain baseline information on the use of CCs. All participants enrolled in the study will receive a JUUL e-cigarette at Visit 2 for ad libitum use. After the first week of e-cigarette use (at Visit 3), participants will be given bupropion (150 mg each morning for days 1-3, then 300 mg daily) with either zonisamide (100 mg daily) or placebo (group 1 and
Behavioral Intervention
Pharmacological and Behavioral Treatment for Obesity After Bariatric Surgery
Recruiting0 awardsPhase 2 & 3
New Haven, Connecticut
This trial tests a special program and two medications to help people lose weight after weight-loss surgery. It targets patients who still struggle with obesity despite having surgery. The program helps change daily habits, while the medications reduce hunger and cravings.
Chemotherapy
Physical Therapy + Antidepressant for Chronic Lower Back Pain with Depression
Recruiting1 awardPhase 2 & 3
Chestnut Hill, Massachusetts
This trial will look at how different treatments - antidepressants, physical therapy, or a combination of both - affect pain, ability to function, and depression symptoms in people with chronic low back pain.
Trials With No Placebo
Behavioural Intervention
Smoking Cessation Cognitive Behavioral Therapy (CBT) for Post-Traumatic Stress Disorder (PTSD)
Recruiting5 awardsPhase 4
Durham, North Carolina
This trial will test a treatment that combines cognitive processing therapy with cognitive-behavioral counseling for smoking cessation, contingency management, and smoking cessation medication to see if it is more effective than just cognitive processing therapy for reducing smoking among veterans with PTSD.
Chemotherapy
Physical Therapy + Antidepressant for Chronic Lower Back Pain with Depression
Recruiting1 awardPhase 2 & 3
Chestnut Hill, Massachusetts
This trial will look at how different treatments - antidepressants, physical therapy, or a combination of both - affect pain, ability to function, and depression symptoms in people with chronic low back pain.
Behavioural Intervention
Smoking Cessation Program for Cancer
Recruiting3 awards6 criteria
Philadelphia, Pennsylvania
This trial studies how well a comprehensive smoking cessation program (ETIP) works in helping head and neck and lung cancer patients reduce cigarette use. ETIP includes personalized counseling, medication, nicotine patches or gum, and ongoing support. It aims to provide support, reduce cravings, and ease withdrawal symptoms.
View More Related Trials
Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.