Dr. Abeer M Mohamed, MD, PhD
Claim this profileUniversity of Illinois at Chicago
Studies Obesity
Studies Vascular Dysfunction
2 reported clinical trials
1 drug studied
Affiliated Hospitals
Clinical Trials Abeer M Mohamed, MD, PhD is currently running
Exercise Training
for Cardiovascular Disease
The development of type II diabetes (T2D) is strongly associated with obesity and both are well-established risk factors for cardiovascular disease. Knowing that vascular dysfunction is an early event in the development of cardiovascular disease in obese diabetic (OB-T2D) patients, The investigators set their long-term goal to define molecular mechanisms of vascular dysfunction and corrective strategies that target these mechanisms such as physical activity and weight loss. The investigators recently discovered that human adipose tissues release extracellular vesicles (adiposomes) that are efficiently captured by endothelial cells. Adiposomes are known to carry bioactive cargos such as proteins and micro RNAs; however, their lipid content has not been studied nor has their ability to transfer their lipid cargo to endothelial cells. In the current application, the investigators propose to investigate the role of adiposomes in communicating the unhealthy milieu, mainly dysregulated lipids, to endothelial cells in OB-T2D subjects. On top of these lipid species that the investigators propose to be carried by adiposomes are glycosphingolipids (GSLs). These lipids originate from the glycosylation of ceramides, a chemical process that is upregulated in the presence of inflammation and high glucose levels. Preliminary findings showed that in endothelial cells, GSL-rich adiposomes disturb plasma membrane structure and subsequently induce endothelial dysfunction. Moreover, the investigators found that preconditioning endothelial cells with high shear stress (which is an exercise mimetic) protected endothelial cells from the detrimental effects induced by adiposomes. Therefore, the central hypothesis is that adipose tissues in OB-T2D patients release GSL-loaded adiposomes that induce vascular endothelial dysfunction. The researchers propose that exercise and weight loss interventions (bariatric surgery) will restore adipose tissue homeostasis, reduce GSL-loaded adiposomes, and subsequently alleviate vascular risk in OB-T2D patients. The investigators will test the hypotheses by pursuing the following aims: aim 1: Investigate the role of GSL-rich adiposomes in the pathogenesis of endothelial dysfunction in OB-T2D adults; aim 2: Test the effectiveness of exercise training in reducing adiposome-mediated effects on vascular function; and aim 3: Examine changes in adiposome/caveolae axis following metabolic surgery and their association with vascular function.
Recruiting1 award N/A
Exercise Training
for Vascular Dysfunction in Obesity
The main objective is to examine DNA hypomethylation as an underlying mechanism for the increased production of inflammatory cytokines and the impaired vascular function in obese individuals and as a potential target for nonpharmacological preventive/therapeutic interventions such as aerobic exercise.
Recruiting1 award N/A4 criteria
More about Abeer M Mohamed, MD, PhD
Clinical Trial Related2 years of experience running clinical trials · Led 2 trials as a Principal Investigator · 2 Active Clinical TrialsTreatments Abeer M Mohamed, MD, PhD has experience with
- Exercise Training
Breakdown of trials Abeer M Mohamed, MD, PhD has run
Obesity
Vascular Dysfunction
Cardiovascular Disease
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Abeer M Mohamed, MD, PhD specialize in?
Abeer M Mohamed, MD, PhD focuses on Obesity and Vascular Dysfunction. In particular, much of their work with Obesity has involved treating patients, or patients who are undergoing treatment.
Is Abeer M Mohamed, MD, PhD currently recruiting for clinical trials?
Yes, Abeer M Mohamed, MD, PhD is currently recruiting for 2 clinical trials in Chicago Illinois. If you're interested in participating, you should apply.
Are there any treatments that Abeer M Mohamed, MD, PhD has studied deeply?
Yes, Abeer M Mohamed, MD, PhD has studied treatments such as Exercise training.
What is the best way to schedule an appointment with Abeer M Mohamed, MD, PhD?
Apply for one of the trials that Abeer M Mohamed, MD, PhD is conducting.
What is the office address of Abeer M Mohamed, MD, PhD?
The office of Abeer M Mohamed, MD, PhD is located at: University of Illinois at Chicago, Chicago, Illinois 60612 United States. This is the address for their practice at the University of Illinois at Chicago.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.