Dr. Alys Malcolm
Claim this profileSteward Saint Elizabeth's Medical Center
Studies Breast Cancer
Studies Colon Cancer
5 reported clinical trials
19 drugs studied
Area of expertise
1Breast Cancer
Stage II
HER2 negative
ER or PR positive
2Colon Cancer
Stage III
MSS positive
MMR positive
Affiliated Hospitals
Clinical Trials Alys Malcolm is currently running
Chemotherapy + Immunotherapy
for Esophageal and Gastric Cancer
This phase III trial compares the effect of modified fluorouracil, leucovorin calcium, oxaliplatin, and irinotecan (mFOLFIRINOX) to modified fluorouracil, leucovorin calcium, and oxaliplatin (mFOLFOX) for the treatment of advanced, unresectable, or metastatic HER2 negative esophageal, gastroesophageal junction, and gastric adenocarcinoma. The usual approach for patients is treatment with FOLFOX chemotherapy. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Fluorouracil stops cells from making DNA and it may kill tumor cells. Leucovorin is used with fluorouracil to enhance the effects of the drug. Oxaliplatin works by killing, stopping, or slowing the growth of tumor cells. Some patients also receive an immunotherapy drug, nivolumab, in addition to FOLFOX chemotherapy. Immunotherapy may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. Irinotecan blocks certain enzymes needed for cell division and DNA repair, and it may kill tumor cells. Adding irinotecan to the FOLFOX regimen could shrink the cancer and extend the life of patients with advanced gastroesophageal cancers.
Recruiting2 awards Phase 32 criteria
Immunotherapy + Chemotherapy
for Non-Small Cell Lung Cancer
This phase III ALCHEMIST trial tests the addition of pembrolizumab to usual chemotherapy for the treatment of stage IIA, IIB, IIIA or IIIB non-small cell lung cancer that has been removed by surgery. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as cisplatin, pemetrexed, carboplatin, gemcitabine hydrochloride, and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving pembrolizumab with usual chemotherapy may help increase survival times in patients with stage IIA, IIB, IIIA or IIIB non-small cell lung cancer.
Recruiting2 awards Phase 327 criteria
More about Alys Malcolm
Clinical Trial Related1 year of experience running clinical trials · Led 5 trials as a Principal Investigator · 5 Active Clinical TrialsTreatments Alys Malcolm has experience with
- Tamoxifen
- Exemestane
- MFOLFIRINOX
- Abemaciclib
- Anastrozole/Letrozole
- LHRH Agonist
Breakdown of trials Alys Malcolm has run
Breast Cancer
Colorectal Cancer
Gastroesophageal Junction Adenocarcinoma
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Alys Malcolm specialize in?
Alys Malcolm focuses on Breast Cancer and Colon Cancer. In particular, much of their work with Breast Cancer has involved Stage II patients, or patients who are HER2 negative.
Is Alys Malcolm currently recruiting for clinical trials?
Yes, Alys Malcolm is currently recruiting for 5 clinical trials in Brighton Massachusetts. If you're interested in participating, you should apply.
Are there any treatments that Alys Malcolm has studied deeply?
Yes, Alys Malcolm has studied treatments such as Tamoxifen, Exemestane, mFOLFIRINOX.
What is the best way to schedule an appointment with Alys Malcolm?
Apply for one of the trials that Alys Malcolm is conducting.
What is the office address of Alys Malcolm?
The office of Alys Malcolm is located at: Steward Saint Elizabeth's Medical Center, Brighton, Massachusetts 02135 United States. This is the address for their practice at the Steward Saint Elizabeth's Medical Center.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.