Andrew Krystal | UCSF Health

Dr. Andrew Krystal, MD, MS

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University of California, San Francisco

Studies Depression
Studies Major Depressive Disorder
6 reported clinical trials
12 drugs studied

Affiliated Hospitals

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University Of California, San Francisco

Clinical Trials Andrew Krystal, MD, MS is currently running

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Deep Brain Stimulation

for Obsessive-Compulsive Disorder

This is a double-blinded, randomized, crossover study design for SEEG-guided 4-lead DBS for treatment-refractory OCD, followed by open label stimulation for an additional 6 months. The study will be conducted in 3 stages: Stage 1 will consist of SEEG brain mapping and optimization of stimulation parameters. Stage 2 will consist of 4-lead DBS surgery with bilateral IPGs and further optimization of stimulation parameters. Stage 3 will be randomized, crossover treatment, followed by open label treatment.

Recruiting

1 award

N/A

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Deep Brain Stimulation

for Depression

Neurons are specialized types of cells that are responsible for carrying out the functions of the brain. Neurons communicate with electrical signals. In diseases such as major depression this electrical communication can go awry. One way to change brain function is using electrical stimulation to help alter the communication between groups of neurons in the brain. The purpose of this study is to test a personalized approach to brain stimulation as an intervention for depression. The study researchers will use a surgically implanted device to measure each individual's brain activity related to his/her depression. The researchers will then use small electrical impulses to alter that brain activity and measure whether these changes help reduce depression symptoms. This study is intended for patients with major depression whose symptoms have not been adequately treated with currently available therapies. The device used in this study is called the NeuroPace Responsive Neurostimulation (RNS) System. It is currently FDA approved to treat patients with epilepsy. The study will test whether personalized responsive neurostimulation can safely and effectively treat depression.

Recruiting

0 awards

N/A

More about Andrew Krystal, MD, MS

Clinical Trial Related

1 year of experience running clinical trials · Led 6 trials as a Principal Investigator · 3 Active Clinical Trials

Treatments Andrew Krystal, MD, MS has experience with

  • Reduction Of Ultra-processed Foods
  • Deep Brain Stimulation
  • Care As Usual (CAU) Plan
  • CGT
  • MBSST
  • Methylphenidate

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