Dr. Anthony Adili, M.D
Claim this profileSt. Joseph's Healthcare Hamilton
Studies Osteoarthritis
Studies Postoperative Pain
4 reported clinical trials
8 drugs studied
Affiliated Hospitals
Clinical Trials Anthony Adili, M.D is currently running
FitJoints Program
for Hip and Knee Osteoarthritis
Total hip or knee replacement is an important and cost-effective surgical intervention to relieve pain and improve independence and function in patients with osteoarthritis. The number of people waiting for elective surgeries has spiked in the COVID-19 pandemic. Prior to COVID-19, up to 40% of patients receiving joint replacement were frail and this number is rapidly increasing with longer wait-times and deconditioning associated with COVID-19 physical distancing. There is an urgent need to be responsive to the evolving challenges of healthcare. The proposed study is the first multi-site randomized controlled trial (RCT) to examine whether a multimodal frailty reduction intervention before surgery will improve postsurgical outcomes for this population. The COVID-19 adapted hybrid model includes a multimodal frailty intervention that may be implemented either in person or virtually and is aligned with international consensus guidelines on frailty reduction. To utilize the FitJoints multimodal frailty intervention to build resilience of patients undergoing joint replacement surgery to improve post-operative outcomes. The investigators hypothesize the FitJoints multimodal frailty intervention, with exercise, nutrition and medication optimization, will reduce frailty and pain while improving function and quality of life. Building upon the success of the FitJoints feasibility study (n=69) in Hamilton, Ontario, in the proposed multi-site RCT (n=192), older adults (≥60 years) undergoing hip or knee joint replacement surgery who are frail will be randomized to either the 3 to 6-months of multimodal intervention or usual care until the date of their surgery at multiple sites (Hamilton Health Sciences \& St Joseph's Healthcare Hamilton, ON; London Health Science Centre, London, ON; Foothills Hospital, Calgary, AB),The FitJoints evidence-based, multimodal intervention includes a hybrid model that can be implemented either in person or virtually: 1. Physiotherapist supported multi-component exercise program 2. Nutrition and protein optimization including dietary counseling 3. Medication review with prescribing recommendations
Recruiting1 award N/A
CBD
for Persistent Post-Surgical Pain After Knee Replacement
Each year, approximately 75,000 Canadians undergo knee replacement surgery, and up to 25% develop persistent post-surgical pain. Persistent post-surgical pain is associated with depression, anxiety, unemployment, and reduced quality of life. Chronic pain after surgery is often managed with opioid therapy, which typically provides only modest benefits and is associated with rare but serious adverse events, such as overdose and death. A number of studies have found that greater pain just before and after knee replacement surgery is associated with the development of chronic pain, suggesting that reducing peri-operative pain may help prevent persistent post-surgical pain. Medicinal cannabis has begun to emerge as a potential therapy for pain reduction, and produces effects largely due to 2 active components: (1) cannabidiol (CBD), and (2) tetrahydrocannabinol (THC). Studies of CBD have shown analgesic, anti-inflammatory, and anti-anxiety properties, but without the psychoactive effects (feeling 'high') that THC produces. This study will assess the feasibility of a definitive trial to explore whether adding CBD dominant vs. placebo to usual care before and after surgery can reduce the rate of persistent post-surgical pain after total knee replacement. This study will randomize 40 patients to receive either CBD dominant or placebo, and follow them for six months to confirm our ability to recruit patients, adhere to protocol, and capture full outcome data for at least 85% of patients.
Recruiting1 award Phase 34 criteria
More about Anthony Adili, M.D
Clinical Trial Related2 years of experience running clinical trials · Led 4 trials as a Principal Investigator · 2 Active Clinical TrialsTreatments Anthony Adili, M.D has experience with
- FitJoints Multi-modal Intervention
- Cannabidiol (CBD)
- Placebo Oil For Oral Use
- MPL-001
- Placebo Oral Capsule
- Multicomponent Opioid Reduction And Pain Management Pathway
Breakdown of trials Anthony Adili, M.D has run
Osteoarthritis
Postoperative Pain
Hip Osteoarthritis
Complications
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Anthony Adili, M.D specialize in?
Anthony Adili, M.D focuses on Osteoarthritis and Postoperative Pain. In particular, much of their work with Osteoarthritis has involved treating patients, or patients who are undergoing treatment.
Is Anthony Adili, M.D currently recruiting for clinical trials?
Yes, Anthony Adili, M.D is currently recruiting for 2 clinical trials in Hamilton Ontario. If you're interested in participating, you should apply.
Are there any treatments that Anthony Adili, M.D has studied deeply?
Yes, Anthony Adili, M.D has studied treatments such as FitJoints Multi-modal Intervention, Cannabidiol (CBD), Placebo oil for oral use.
What is the best way to schedule an appointment with Anthony Adili, M.D?
Apply for one of the trials that Anthony Adili, M.D is conducting.
What is the office address of Anthony Adili, M.D?
The office of Anthony Adili, M.D is located at: St. Joseph's Healthcare Hamilton, Hamilton, Ontario L8N 4A6 Canada. This is the address for their practice at the St. Joseph's Healthcare Hamilton.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.