Dr. Christopher D. Fletcher, MD ...

Dr. Christopher D Fletcher, MD

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William S Middleton VA Medical Center

Studies Lymphoma
Studies Diffuse Large B-Cell Lymphoma
6 reported clinical trials
24 drugs studied

Area of expertise

1

Lymphoma

Christopher D Fletcher, MD has run 3 trials for Lymphoma. Some of their research focus areas include:

Stage II
Stage III
Stage IV
2

Diffuse Large B-Cell Lymphoma

Christopher D Fletcher, MD has run 2 trials for Diffuse Large B-Cell Lymphoma. Some of their research focus areas include:

CD20 positive
Stage II
Stage III

Affiliated Hospitals

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William S Middleton VA Medical Center

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University Of Wisconsin - Carbone Cancer Center

Clinical Trials Christopher D Fletcher, MD is currently running

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Venetoclax + HMA

for Acute Myeloid Leukemia

This phase II MyeloMATCH treatment trial compares the usual treatment of azacitidine and venetoclax to the combination treatment of azacitidine, venetoclax and gilteritinib in treating older and unfit patients with acute myeloid leukemia and FLT3 mutations. Azacitidine is a drug that is absorbed into DNA and leads to the activation of cancer suppressor genes, which are genes that help control cell growth. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Gilteritinib is in a class of medications called kinase inhibitors. It works by blocking the action of a certain naturally occurring substance that may be needed to help cancer cells multiply. This study may help doctors find out if these different approaches are better than the usual approaches. To decide if they are better, the study doctors are looking to see if the study drugs lead to a higher percentage of patients achieving a deeper remission compared to the usual approach.

Recruiting

1 award

Phase 2

7 criteria

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Combination Therapy

for Multiple Myeloma

This phase III trial compares the combination of four drugs (daratumumab, bortezomib, lenalidomide and dexamethasone) to the use of a three drug combination (daratumumab, lenalidomide and dexamethasone). Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Chemotherapy drugs, such as lenalidomide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Daratumumab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. Anti-inflammatory drugs, such as dexamethasone lower the body's immune response and are used with other drugs in the treatment of some types of cancer. Adding bortezomib to daratumumab, lenalidomide, and dexamethasone may be more effective in shrinking the cancer or preventing it from returning, compared to continuing on daratumumab, lenalidomide, and dexamethasone.

Recruiting

2 awards

Phase 3

32 criteria

More about Christopher D Fletcher, MD

Clinical Trial Related

6 years of experience running clinical trials · Led 6 trials as a Principal Investigator · 3 Active Clinical Trials

Treatments Christopher D Fletcher, MD has experience with

  • Venetoclax
  • Lenalidomide
  • Azacitidine
  • Blinatumomab
  • Bortezomib
  • Daratumumab And Hyaluronidase-fihj

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