Christopher C. Thompson, MD - Brigham ...

Dr. Christopher Thompson, MD

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Brigham and Women's Hospital

Studies Obesity
Studies Weight Loss
11 reported clinical trials
15 drugs studied

Affiliated Hospitals

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Brigham And Women's Hospital

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Mercy Oncology Research Oklahoma City

Clinical Trials Christopher Thompson, MD is currently running

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RESET Liner

for Type-2 Diabetes and Obesity

This trial is testing the RESET System, a device placed in the stomach, to help people with Type 2 Diabetes and Obesity who haven't controlled their blood sugar well with current medications. The device works by reducing food absorption, aiding in better blood sugar control and weight loss. The RESET System has been shown to help with weight loss and better blood sugar control in patients with type 2 diabetes.

Recruiting

0 awards

N/A

3 criteria

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Argon Plasma

for Helicobacter Pylori Infection

The objective of the study is to investigate the efficacy and safety of an argon plasma-based therapy - HEAPE - in treating H. pylori infections during endoscopic procedures. By filling the stomach with sodium chloride solution that is treated with APC (PAL), the Investigators hypothesize a significant reduction in H. pylori. The use of PAL instead of direct application of APC allows for a broader and more homogeneous application throughout the stomach and a faster procedure time, as the fluid bypasses the thermal effects typically associated with higher electrical power settings and focuses on the bactericidal action of PAL. It is a procedure that does not involve thermal ablation of the stomach lining. Thus, side effects should be expected to be as low as possible. Two different PAL generation modalities will be compared in this study: 1. HEAPE direct: This modality is the direct generation of PAL in the stomach. The stomach is filled with sodium chloride solution which is then treated with APC. With HEAPE direct a potential decrease of reactive species is avoided, as the treatment happens directly at the intended location in the H. pylori infected stomach. 2. Pre-HEAPE: This modality features the treatment of sodium chloride with APC outside of the patient in a sterile container. After the APC treatment, the generated PAL is administered into the stomach with a syringe through the working channel of the endoscope. Pre-HEAPE allows an easier handling of the APC probe as the treatment of the sodium chloride solution can be done without an endoscope. To evaluate the immediate effect of this novel treatment approach the metabolic activity of H. pylori will be assessed using a urea breath test (UBT) before and after treatment. A reduction in H. pylori levels can be detected by a reduction in urease activity in the breath test. After the HEAPE procedure, patients are treated with antibiotics (best practice) as they would be under normal circumstances. Four weeks after treatment, another UBT is performed to determine if H. pylori has been eradicated or if additional antibiotic treatment is indicated. This two-arm, randomized, pilot, single-center, prospective clinical study is designed to evaluate the safety, tolerability and proof of concept that PAL has the ability to eradicate or reduce the bacterial load of H. pylori in humans.

Recruiting

1 award

N/A

1 criteria

More about Christopher Thompson, MD

Clinical Trial Related

7 years of experience running clinical trials · Led 11 trials as a Principal Investigator · 5 Active Clinical Trials

Treatments Christopher Thompson, MD has experience with

  • Endoscopic Sleeve Gastroplasty - Belt
  • Endoscopic Sleeve Gastroplasty - Belt And Suspenders
  • HEAPE
  • Pre-HEAPE
  • Low Thermal Plasma (LTP) Treatment
  • Cryotechnology Necrosectomy Procedure

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