Dr. Darryl Leong, MD
Claim this profileHamilton General Hospital
Area of expertise
Heart Failure
Darryl Leong, MD has run 2 trials for Heart Failure. Some of their research focus areas include:
Cancer
Darryl Leong, MD has run 2 trials for Cancer.
Affiliated Hospitals
Hamilton General Hospital
McMaster University
Clinical Trials Darryl Leong, MD is currently running
Stopping Heart Medications
for Cancer Survivors
Cancer therapy-related cardiac dysfunction (CTRCD) is when the heart's ability to pump oxygenated blood to the body is compromised. It is a side effect of cancer therapy which can occur as commonly as in 1 in 5 patients. When this occurs, heart failure medications are started to protect the heart from progressing to heart failure. With early detection and treatment, heart function recovers to normal in \>80% of patients. Unfortunately, heart failure medications are associated with an undesirable long-term pill burden, financial costs, and side-effects (e.g., dizziness and fatigue). As a result, cancer survivors frequently ask if they can safely stop their heart failure medications once their heart function has returned to normal. Currently there is no scientific evidence in this area of Cardio-Oncology. To address this knowledge gap, the investigators have designed a randomized control trial to assess the safety of stopping heart failure medication in patients with CTRCD and recovered heart function. The investigators will enrol patients who have completed their cancer therapy and are on heart medications for their CTRCD, which has now normalized. The investigators will randomize patients with no other reasons to continue heart failure medications (e.g., kidney disease) to continuing or stopping their heart medications safely. All patients will undergo a cardiac MRI at baseline, 1 and 5 years with safety assessments at 6-8 weeks, 6 months and 3 and 5 years. The investigators will determine if stopping medications is non-inferior to continuing medications by counting the numbers of patients who develop heart dysfunction by 1 year in each group.
Recruiting
3 awards
Phase 4
Abatacept
for Myocarditis
This Trial tests if abatacept can reduce serious heart problems in patients with heart inflammation caused by cancer treatments. Abatacept calms the immune system by preventing certain immune cells from becoming fully active, reducing inflammation and damage. Abatacept has been approved by the US Food and Drug Administration for the treatment of rheumatoid arthritis, with or without methotrexate.
Recruiting
3 awards
Phase 3
11 criteria
More about Darryl Leong, MD
Clinical Trial Related
1 year of experience running clinical trials · Led 3 trials as a Principal Investigator · 3 Active Clinical Trials
Treatments Darryl Leong, MD has experience with
- Pertuzumab
- Trastuzumab
- Trastuzumab Emtansine
- Stopping Heart Failure Medication(s)
- Abatacept
- Placebo
Breakdown of trials Darryl Leong, MD has run
Heart Failure
Breast Cancer
Cardiotoxicity
Cardiac Toxicity
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Darryl Leong, MD specialize in?
Darryl Leong, MD focuses on Heart Failure and Cancer. In particular, much of their work with Heart Failure has involved Stage I patients, or patients who are Stage II.
Is Darryl Leong, MD currently recruiting for clinical trials?
Yes, Darryl Leong, MD is currently recruiting for 3 clinical trials in Hamilton Ontario. If you're interested in participating, you should apply.
Are there any treatments that Darryl Leong, MD has studied deeply?
Yes, Darryl Leong, MD has studied treatments such as Pertuzumab, Trastuzumab, Trastuzumab emtansine.
What is the best way to schedule an appointment with Darryl Leong, MD?
Apply for one of the trials that Darryl Leong, MD is conducting.
What is the office address of Darryl Leong, MD?
The office of Darryl Leong, MD is located at: Hamilton General Hospital, Hamilton, Ontario L8L 2X2 Canada. This is the address for their practice at the Hamilton General Hospital.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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