Dr. David Smith, MD
Claim this profileMonroe Biomedical Research
Studies Iron Deficiency
Studies Iron-Deficiency Anemia
6 reported clinical trials
8 drugs studied
Affiliated Hospitals
Clinical Trials David Smith, MD is currently running
CAR T Cells
for HIV
Human immunodeficiency virus type 1 (HIV-1) causes a persistent infection that ultimately leads to acquired immunodeficiency syndrome (AIDS). Treatment of HIV-1 infection with combination anti-retroviral therapy (ART) suppresses HIV-1 replication to undetectable viral levels and saves lives. Nevertheless, ART cannot eradicate latent cellular reservoirs of the virus, and HIV-1 infection remains a life-long battle. Adoptive cellular immunotherapy using chimeric antigen receptor (CAR) engineered T cells directed against HIV-1 envelope subunit protein gp120 (HIVCAR T cells) may provide a safe and effective way to eliminate HIV-infected cells. However, the number of HIV-infected cells is low in participants under ART, and CAR T cells disappear if they are not stimulated by their target antigens. Interestingly, about 95% of HIV-1-infected individuals are CMV-seropositive and CMV-specific T cells have been shown to persist. To overcome the CAR T cells low persistence issue, we propose to make HIV-CAR T cells using autologous cytomegalovirus (CMV)-specific T cells, which can be stimulated by endogenous CMV in vivo. The overall hypothesis of this first-in-human Phase 1, open-label, single-arm study is that endogenous immune signals to CMV-specific T cells can maintain the presence of autologous bispecific CMV/HIV-CAR T cells in healthy people living with HIV-1 (PLWH), and achieve long-term remission in the presence of ART.
Recruiting1 award Phase < 1
Vitamin C
for Thermal Burns
This study aims to show that giving high dose, intravenous vitamin C in addition to standard care to burned critically ill patients will be associated with less organ dysfunction, improved survival and a quicker rate of recovery. In this study, all patients will receive standard care and of the patients will also receive high dose intravenous vitamin C, while the other half of patients will receive placebo.
Recruiting1 award Phase 33 criteria
More about David Smith, MD
Clinical Trial Related1 year of experience running clinical trials · Led 6 trials as a Principal Investigator · 3 Active Clinical TrialsTreatments David Smith, MD has experience with
- Placebo
- Ferric Carboxymaltose
- Bentracimab (PB2452)
- Ensifentrine
- Albumin Human
- CMV/HIV-CAR T Cells
Breakdown of trials David Smith, MD has run
Iron Deficiency
Iron-Deficiency Anemia
Heart Failure
Healthy Subjects
Chronic Obstructive Pulmonary Disease
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does David Smith, MD specialize in?
David Smith, MD focuses on Iron Deficiency and Iron-Deficiency Anemia. In particular, much of their work with Iron Deficiency has involved treating patients, or patients who are undergoing treatment.
Is David Smith, MD currently recruiting for clinical trials?
Yes, David Smith, MD is currently recruiting for 3 clinical trials in Monroe North Carolina. If you're interested in participating, you should apply.
Are there any treatments that David Smith, MD has studied deeply?
Yes, David Smith, MD has studied treatments such as Placebo, Ferric Carboxymaltose, Bentracimab (PB2452).
What is the best way to schedule an appointment with David Smith, MD?
Apply for one of the trials that David Smith, MD is conducting.
What is the office address of David Smith, MD?
The office of David Smith, MD is located at: Monroe Biomedical Research, Monroe, North Carolina 28112 United States. This is the address for their practice at the Monroe Biomedical Research.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.