Dr. James Ronald, MD PhD

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Studies Encephalopathy
Studies Hepatic Encephalopathy
1 reported clinical trial
1 drug studied

Clinical Trials James Ronald, MD PhD is currently running

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Proton Pump Inhibitor Deprescribing

for Hepatic Encephalopathy

A total of 40 patients taking proton pump inhibitors (PPIs) who undergo transjugular intrahepatic portosystemic shunt (TIPS) creation as part of routine clinical care will be randomized in 1:1 fashion to either continue or discontinue their PPIs to determine whether these commonly used gastric acid suppressing agents increase risk of post-TIPS hepatic encephalopathy (HE). Patients will be assessed for symptoms of minimal HE (MHE), using the established psychometric hepatic encephalopathy score (PHES) battery of tests. MHE assessment will be conducted at two timepoints: at baseline prior to randomization and TIPS creation and approximately 4 weeks after randomization and TIPS creation. Stool samples will also be collected at both timepoints to allow characterization of the gastrointestinal (GI) tract microbiome using 16S rRNA sequencing. The pre to post-TIPS change in PHES scores will be compared between patients randomized to continue versus discontinue their PPIs. Quality of life (QOL) will also be assessed. Changes in the GI tract microbiome will be analyzed to determine whether this represents a potential biological mechanism linking PPI use with post-TIPS HE.
Recruiting1 award Phase 1 & 25 criteria

More about James Ronald, MD PhD

Clinical Trial Related3 years of experience running clinical trials · Led 1 trial as a Principal Investigator · 1 Active Clinical Trial
Treatments James Ronald, MD PhD has experience with
  • PPI
Breakdown of trials James Ronald, MD PhD has run
Encephalopathy
Hepatic Encephalopathy

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Frequently asked questions

Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does James Ronald, MD PhD specialize in?
James Ronald, MD PhD focuses on Encephalopathy and Hepatic Encephalopathy. In particular, much of their work with Encephalopathy has involved treating patients, or patients who are undergoing treatment.
Is James Ronald, MD PhD currently recruiting for clinical trials?
Yes, James Ronald, MD PhD is currently recruiting for 1 clinical trial in the USA. If you're interested in participating, you should apply.
Are there any treatments that James Ronald, MD PhD has studied deeply?
Yes, James Ronald, MD PhD has studied treatments such as PPI.
What is the best way to schedule an appointment with James Ronald, MD PhD?
Apply for one of the trials that James Ronald, MD PhD is conducting.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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