Dr. Jason Allen, PhD
Claim this profileUniversity of Virginia
Studies Peripheral Arterial Disease
Studies Peripheral Artery Disease
7 reported clinical trials
15 drugs studied
Affiliated Hospitals
Clinical Trials Jason Allen, PhD is currently running
Metformin
for Exercise Capacity
Metformin is the most prescribed blood sugar (glucose)-lowering medication for patients diagnosed with type 2 diabetes mellitus (T2DM). Metformin stimulates glucose uptake in skeletal muscle similar to the effects of exercise, though, some studies report that metformin may decrease exercise capacity. The main question this study looks to answer is: • Does metformin alter exercise capacity? Participants will: * Complete 5 exercise tests on a stationary bike. * Undergo a body composition test. * Take metformin and placebo. * Complete food and symptom logs. The researchers hypothesize that: • Metformin will reduce aerobic capacity.
Recruiting2 awards Phase 43 criteria
Beetroot Juice
for Peripheral Arterial Disease
The BEET PAD Trial is a multi-centered double-blind randomized clinical trial designed to determine whether beetroot juice, compared to placebo, improves six-minute walk distance at four month follow-up in people with lower extremity peripheral artery disease (PAD). Investigators hypothesize that by simultaneously increasing lower extremity perfusion, gastrocnemius muscle mitochondrial activity, and myofiber health and regeneration, beetroot juice will significantly improve walking performance in people with PAD. The primary aim is to determine whether beetroot juice significantly improves six-minute walk distance at 4-month follow-up in people with PAD, compared to placebo. Preliminary evidence suggests that beetroot juice has both acute and chronic effects on walking performance in PAD. The primary outcome will measure the combined acute and chronic effect of beetroot juice (i.e. the maximal effect) on change in 6-minute walk at 4-month follow-up. In secondary aims, investigators will distinguish between acute and chronic effects of beetroot juice on six-minute walk and delineate biologic pathways by which beetroot juice improves walking performance in PAD, by measuring change in gastrocnemius muscle perfusion (MRI arterial spin labeling) and gastrocnemius muscle health. The trial will assess the durability of beetroot juice effects on six-minute walk. Nitrate in beetroot juice is metabolized to nitrite and subsequently to NO, attaining peak nitrite levels 2.5 hours after ingestion. The trial will determine whether a higher peak or a greater increase in plasma nitrite at 2.5 hours after beetroot juice consumption at baseline has a greater effect on six-minute walk at 4-month follow-up, compared to a lower peak or a smaller increase, respectively.
Recruiting0 awards N/A5 criteria
More about Jason Allen, PhD
Clinical Trial Related1 year of experience running clinical trials · Led 7 trials as a Principal Investigator · 5 Active Clinical TrialsTreatments Jason Allen, PhD has experience with
- Metformin
- COMBO
- PRIME
- Beetroot Juice
- Placebo
- Home-Based Exercise
Breakdown of trials Jason Allen, PhD has run
Peripheral Arterial Disease
Peripheral Artery Disease
Peripheral Vascular Disease
Vascular Disease
Metformin
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Jason Allen, PhD specialize in?
Jason Allen, PhD focuses on Peripheral Arterial Disease and Peripheral Artery Disease. In particular, much of their work with Peripheral Arterial Disease has involved treating patients, or patients who are undergoing treatment.
Is Jason Allen, PhD currently recruiting for clinical trials?
Yes, Jason Allen, PhD is currently recruiting for 5 clinical trials in Charlottesville Virginia. If you're interested in participating, you should apply.
Are there any treatments that Jason Allen, PhD has studied deeply?
Yes, Jason Allen, PhD has studied treatments such as Metformin, COMBO, PRIME.
What is the best way to schedule an appointment with Jason Allen, PhD?
Apply for one of the trials that Jason Allen, PhD is conducting.
What is the office address of Jason Allen, PhD?
The office of Jason Allen, PhD is located at: University of Virginia, Charlottesville, Virginia 22903 United States. This is the address for their practice at the University of Virginia.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.