Jason Gaglia, MD, MMSc | Joslin ...

Dr. Jason Gaglia, Dr.

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Joslin Diabetes Center

Studies Type 1 Diabetes
Studies Diabetes
7 reported clinical trials
8 drugs studied

Area of expertise

1

Type 1 Diabetes

Jason Gaglia, Dr. has run 7 trials for Type 1 Diabetes. Some of their research focus areas include:

HLA positive
GAD65 positive
C peptide
2

Diabetes

Jason Gaglia, Dr. has run 3 trials for Diabetes.

Affiliated Hospitals

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Joslin Diabetes Center

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Joslin Diabetes Center, Harvard Medical School

Clinical Trials Jason Gaglia, Dr. is currently running

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Observational Study

for Type 1 Diabetes

This is a multi-center, prospective, non-interventional study that focuses on the long- term effects following participation in selected ITN new-onset Type1 Diabetes Mellitus studies with immunomodulatory agents (T1DM, T1D). This observational study will: * follow participants to determine how long they continue to produce insulin, and * will also assess how changes in the immune system over time relate to the ability to produce insulin. This information could help design better therapies for type 1 diabetes in the future.

Recruiting

1 award

N/A

2 criteria

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Prevention

for Type 1 Diabetes

Rationale: The accrual of data from the laboratory and from epidemiologic and prevention trials has improved the understanding of the etiology and pathogenesis of type 1 diabetes mellitus (T1DM). Genetic and immunologic factors play a key role in the development of T1DM, and characterization of the early metabolic abnormalities in T1DM is steadily increasing. However, information regarding the natural history of T1DM remains incomplete. The TrialNet Natural History Study of the Development of T1DM (Pathway to Prevention Study) has been designed to clarify this picture, and in so doing, will contribute to the development and implementation of studies aimed at prevention of and early treatment in T1DM. Purpose: TrialNet is an international network dedicated to the study, prevention, and early treatment of type 1 diabetes. TrialNet sites are located throughout the United States, Canada, Finland, United Kingdom, Italy, Germany, Sweden, Australia, and New Zealand. TrialNet is dedicated to testing new approaches to the prevention of and early intervention for type 1 diabetes. The goal of the TrialNet Natural History Study of the Development of Type 1 Diabetes is to enhance our understanding of the demographic, immunologic, and metabolic characteristics of individuals at risk for developing type 1 diabetes. The Natural History Study will screen relatives of people with type 1 diabetes to identify those at risk for developing the disease. Relatives of people with type 1 diabetes have about a 5% percent chance of being positive for the antibodies associated with diabetes. TrialNet will identify adults and children at risk for developing diabetes by testing for the presence of these antibodies in the blood. A positive antibody test is an early indication that damage to insulin-secreting cells may have begun. If this test is positive, additional testing will be offered to determine the likelihood that a person may develop diabetes. Individuals with antibodies will be offered the opportunity for further testing to determine their risk of developing diabetes over the next 5 years and to receive close monitoring for the development of diabetes.

Recruiting

1 award

N/A

3 criteria

More about Jason Gaglia, Dr.

Clinical Trial Related

5 years of experience running clinical trials · Led 7 trials as a Principal Investigator · 2 Active Clinical Trials

Treatments Jason Gaglia, Dr. has experience with

  • Placebo
  • Ladarixin
  • Recombinant Human Glutamic Acid Decarboxylase (rhGAD65) Formulated In Alhydrogel®
  • Colecalciferol 2000 IU
  • Placebo For Recombinant Human Glutamic Acid Decarboxylase (rhGAD65) Formulated In Alhydrogel®
  • NNC0361-0041

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