Dr. John O'Toole, M.D., M.S.
Claim this profileCleveland Clinic
Affiliated Hospitals
Cleveland Clinic
Rush University Medical Center: University Neurosurgery
Clinical Trials John O'Toole, M.D., M.S. is currently running
Regional Anesthesia
for Back Surgery
Opioid overuse is a widespread public health crisis in the United States with increasing rates of addiction and overdose deaths from prescription opioids. Reducing the need for opiate analgesics in the post-operative setting has become a high priority in minimizing long-term opioid use in surgical patients. This study will serve to demonstrate the efficacy of the addition of regional analgesic techniques in reducing post-operative opioid requirements in patients undergoing common lumbar spinal surgical procedures.
Recruiting
2 awards
Phase 4
Kidney Biopsy
for Acute and Chronic Kidney Conditions
Acute kidney injury (AKI) and chronic kidney disease (CKD) impose a significant global health burden. Yet, no effective therapies currently exist for AKI, and only a few are available for CKD. Despite significant effort from industry and academia, development of pharmacologic therapies for AKI and CKD has been hampered by: Non-predictive animal models The inability to identify and prioritize human targets The limited availability of human kidney biopsy tissue A poor understanding of AKI and CKD heterogeneity Historically, AKI and CKD have been described as single, uniform diseases. However, growing consensus suggests that different disease pathways lead to different subgroups of AKI and CKD (AKIs and CKDs). Access to human kidney biopsy tissue is a critical first step to define disease heterogeneity and determine the precise molecular pathways that will facilitate identification of specific drug targets and ultimately enable individualized care for people with AKI and CKD. A number of research centers across the United States are collaborating to bring state-of-the-art technologies together to: * Ethically obtain and evaluate kidney biopsies from participants with AKI or CKD * Define disease subgroups * Create a kidney tissue atlas * Identify critical cells, pathways, and targets for novel therapies The KPMP is made up of three distinct, but highly interactive, activity groups: * Recruitment Sites: The recruitment sites (RS) are responsible for recruiting participants with AKI or CKD into the longitudinal study and performing the kidney biopsy. * Tissue Interrogation Sites: The tissue interrogation sites (TIS) are responsible for developing and using innovative technologies to analyze the biopsy tissue. * Central Hub: The central hub is responsible for aggregating, analyzing, and visualizing the generated data and providing scientific, infrastructure, and administrative support for the KPMP consortium.
Recruiting
1 award
N/A
10 criteria
More about John O'Toole, M.D., M.S.
Clinical Trial Related
8 years of experience running clinical trials · Led 3 trials as a Principal Investigator · 2 Active Clinical Trials
Treatments John O'Toole, M.D., M.S. has experience with
- Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution Plus Clonidine
- Normal Saline
- Kidney Biopsy
Breakdown of trials John O'Toole, M.D., M.S. has run
Spondylolisthesis
Synovial Cyst
Spinal Stenosis
Disc Degeneration
Lumbar Spinal Stenosis
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does John O'Toole, M.D., M.S. specialize in?
John O'Toole, M.D., M.S. focuses on Spondylolisthesis and Synovial Cyst. In particular, much of their work with Spondylolisthesis has involved treating patients, or patients who are undergoing treatment.
Is John O'Toole, M.D., M.S. currently recruiting for clinical trials?
Yes, John O'Toole, M.D., M.S. is currently recruiting for 2 clinical trials in Cleveland Ohio. If you're interested in participating, you should apply.
Are there any treatments that John O'Toole, M.D., M.S. has studied deeply?
Yes, John O'Toole, M.D., M.S. has studied treatments such as Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution plus clonidine, Normal Saline, Kidney Biopsy.
What is the best way to schedule an appointment with John O'Toole, M.D., M.S.?
Apply for one of the trials that John O'Toole, M.D., M.S. is conducting.
What is the office address of John O'Toole, M.D., M.S.?
The office of John O'Toole, M.D., M.S. is located at: Cleveland Clinic, Cleveland, Ohio 44195 United States. This is the address for their practice at the Cleveland Clinic.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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