Dr. Jonathan Roberts, MD - Bleeding ...

Dr. Jonathan C Roberts, MD

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Bleeding and Clotting Disorders Institute

Studies Von Willebrand Disease
Studies Hemophilia
9 reported clinical trials
10 drugs studied

Area of expertise

1

Von Willebrand Disease

Jonathan C Roberts, MD has run 4 trials for Von Willebrand Disease. Some of their research focus areas include:

VWF collagen binding positive
VWF activity positive
VWF antigen positive
2

Hemophilia

Jonathan C Roberts, MD has run 2 trials for Hemophilia. Some of their research focus areas include:

VWF collagen binding positive
VWF activity positive
VWF antigen positive

Affiliated Hospitals

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Bleeding And Clotting Disorders Institute

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Memorial Regional Hospital

Clinical Trials Jonathan C Roberts, MD is currently running

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Natural History Study

for Blood Disorders

In parallel with the growth of ATHN's clinical studies, the number of new therapies for all blood disorders is increasing significantly. Some of the recently FDA-approved therapies for congenital and acquired hematologic conditions have not yet demonstrated long-term safety and effectiveness beyond the pivotal trials that led to their approval. In addition, results from well controlled, pivotal studies often cannot be replicated once a therapy has been approved for general use.2,3,4,5 In 2019 alone, the FDA has issued approvals for 24 new therapies for congenital and acquired hematologic conditions.6 In addition, almost 10,000 new studies for hematologic diseases are currently registered on www.clinicaltrials.gov.7 With this increase in potential new therapies possible, it is imperative that clinicians and clinical researchers in the field of non-neoplastic hematology have a uniform, secure, unbiased, and enduring method to collect long-term safety and efficacy data. As emphasized in a recently published review, accurate, uniform and quality national data collection is critical in clinical research, particularly for longitudinal cohort studies covering a lifetime of biologic risk.8

Recruiting

1 award

N/A

1 criteria

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VWF Replacement Therapy

for Von Willebrand Disease

In pregnant women with von Willebrand disease (VWD) who by the third trimester do not have von Willebrand factor (VWF) or factor VIII (FVIII) levels greater than 50-100%, specific guidance is lacking for delivery planning in terms of how high of a VWF level should be achieved to reduce bleeding. This is a prospective, open-label, cohort study in women with VWD using Wilate VWF replacement therapy to maintain trough or minimum VWF levels of 100-150% for delivery and the immediate postpartum period, followed by levels of 50-100% for 5-10 days after delivery, depending upon the route of delivery. The primary objective is to document the rate of primary postpartum hemorrhage (PPH). The secondary objective is to document further effectiveness outcomes and safety.

Recruiting

2 awards

N/A

3 criteria

More about Jonathan C Roberts, MD

Clinical Trial Related

3 years of experience running clinical trials · Led 9 trials as a Principal Investigator · 5 Active Clinical Trials

Treatments Jonathan C Roberts, MD has experience with

  • Emicizumab
  • Wilate
  • Placebo
  • CLBS16
  • Antihemophilic Factor (Recombinant)
  • Von Willebrand Factor (Recombinant)

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