Dr. Keith J. August
Claim this profileChildren's Mercy Hospitals and Clinics
Expert in Tumors
Expert in Leukemia
53 reported clinical trials
110 drugs studied
About Keith J. August
Education:
- Obtained MD (Doctor of Medicine) from the University of Kansas School of Medicine in 1997.
Experience:
- Completed Residency in Pediatrics at Children's Mercy Hospital, Kansas City, MO (1997-2000).
- Undertook Fellowship in Pediatric Cardiology at Children's Mercy Hospital, Kansas City, MO (2000-2003).
- Currently a practicing pediatric cardiologist at Children's Mercy Hospitals and Clinics.
Area of expertise
1Tumors
Global LeaderStage I
Stage IV
Stage II
2Leukemia
Global LeaderNTRK1 positive
NTRK positive
Philadelphia chromosome positive
Affiliated Hospitals
Clinical Trials Keith J. August is currently running
Selumetinib vs. Chemotherapy
for Brain Cancer
This trial is comparing a new drug, selumetinib, with standard chemotherapy to treat patients with a specific type of brain tumor. The patients do not have a certain genetic mutation and are not affected by a genetic disorder. Selumetinib works by blocking enzymes needed for tumor growth, while the standard drugs kill or stop tumor cells from dividing.
Recruiting2 awards Phase 3
Inotuzumab Ozogamicin
for Acute Lymphoblastic Leukemia
This phase III trial studies whether inotuzumab ozogamicin added to post-induction chemotherapy for patients with High-Risk B-cell Acute Lymphoblastic Leukemia (B-ALL) improves outcomes. This trial also studies the outcomes of patients with mixed phenotype acute leukemia (MPAL), and B-lymphoblastic lymphoma (B-LLy) when treated with ALL therapy without inotuzumab ozogamicin. Inotuzumab ozogamicin is a monoclonal antibody, called inotuzumab, linked to a type of chemotherapy called calicheamicin. Inotuzumab attaches to cancer cells in a targeted way and delivers calicheamicin to kill them. Other drugs used in the chemotherapy regimen, such as cyclophosphamide, cytarabine, dexamethasone, doxorubicin, daunorubicin, methotrexate, leucovorin, mercaptopurine, prednisone, thioguanine, vincristine, and pegaspargase or calaspargase pegol work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This trial will also study the outcomes of patients with mixed phenotype acute leukemia (MPAL) and disseminated B lymphoblastic lymphoma (B-LLy) when treated with high-risk ALL chemotherapy. The overall goal of this study is to understand if adding inotuzumab ozogamicin to standard of care chemotherapy maintains or improves outcomes in High Risk B-cell Acute Lymphoblastic Leukemia (HR B-ALL). The first part of the study includes the first two phases of therapy: Induction and Consolidation. This part will collect information on the leukemia, as well as the effects of the initial treatment, to classify patients into post-consolidation treatment groups. On the second part of this study, patients with HR B-ALL will receive the remainder of the chemotherapy cycles (interim maintenance I, delayed intensification, interim maintenance II, maintenance), with some patients randomized to receive inotuzumab. The patients that receive inotuzumab will not receive part of delayed intensification. Other aims of this study include investigating whether treating both males and females with the same duration of chemotherapy maintains outcomes for males who have previously been treated for an additional year compared to girls, as well as to evaluate the best ways to help patients adhere to oral chemotherapy regimens. Finally, this study will be the first to track the outcomes of subjects with disseminated B-cell Lymphoblastic Leukemia (B-LLy) or Mixed Phenotype Acute Leukemia (MPAL) when treated with B-ALL chemotherapy.
Recruiting2 awards Phase 3
More about Keith J. August
Clinical Trial Related4 years of experience running clinical trials · Led 53 trials as a Principal Investigator · 27 Active Clinical TrialsTreatments Keith J. August has experience with
- Cyclophosphamide
- Radiation Therapy
- Etoposide
- Doxorubicin Hydrochloride
- Vincristine Sulfate
- Laboratory Biomarker Analysis
Breakdown of trials Keith J. August has run
Tumors
Leukemia
Neuroblastoma
Brain Tumor
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Keith J. August specialize in?
Keith J. August focuses on Tumors and Leukemia. In particular, much of their work with Tumors has involved Stage I patients, or patients who are Stage IV.
Is Keith J. August currently recruiting for clinical trials?
Yes, Keith J. August is currently recruiting for 20 clinical trials in Kansas City Missouri. If you're interested in participating, you should apply.
Are there any treatments that Keith J. August has studied deeply?
Yes, Keith J. August has studied treatments such as Cyclophosphamide, Radiation Therapy, Etoposide.
What is the best way to schedule an appointment with Keith J. August?
Apply for one of the trials that Keith J. August is conducting.
What is the office address of Keith J. August?
The office of Keith J. August is located at: Children's Mercy Hospitals and Clinics, Kansas City, Missouri 64108 United States. This is the address for their practice at the Children's Mercy Hospitals and Clinics.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.