Dr. Lynnette K Nieman, MD
Claim this profileNational Institutes of Health (NIH) - National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Studies Cushing's Syndrome
Studies Adrenocorticotropic Hormone
3 reported clinical trials
7 drugs studied
Affiliated Hospitals
Clinical Trials Lynnette K Nieman, MD is currently running
Imaging Techniques
for Cushing Syndrome
Between 10% and 15% of patients with endogenous hypercortisolism (Cushing syndrome) have ectopic (non-pituitary) production of adrenocorticotropin hormone (ACTH) that causes cortisol excess. In approximately 50% of these patients, the tumoral source of ACTH cannot be found initially despite very detailed and extensive imaging, including studies such as computed tomography, magnetic resonance imaging, and octreotide scan (Octreoscan) using the standard dose of indium- 111 pentetreotide (\[111In-DTPA-D-Phe\]-pentetreotide). The sensitivity and specificity of structurally based imaging studies depends on anatomic alterations and the size of the tumor. In contrast, positron emission tomography (PET) and somatostatin ligand imaging detect pathologic tissue based on physiologic and biochemical processes within the abnormal tissue. This protocol tests the ability of \[18F\]-L-3,4-dihydroxyphenylalanine (18F-DOPA) PET, and the somatostatin imaging analogue, 68Ga-DOTATATE-PET, to localize the source of ectopic ACTH production.
Recruiting1 award Phase 23 criteria
Desmopressin Test
for Cushing Syndrome
Background: Cushing syndrome (CS) is a set of diseases that develop when the body produces too much adrenocorticotropic hormone (ACTH). ACTH stimulates the production of a hormone called cortisol. Excess cortisol can cause serious issues, such as diabetes, high blood pressure, weight gain, and mood changes. Diagnosing CS early can be difficult. One test used to diagnose CS, the desmopressin (Desmo) stimulation test (DesmoST), has not been studied in enough people to know how accurate it is. Objective: To find ways to improve the DesmoST. Researchers especially want to learn more about how well the DesmoST identifies people with specific ACTH CSs: Cushing disease (CD) and ectopic ACTH syndrome (EAS). Eligibility: People aged 18 to 70 years who have or may have CS, especially CD or EAS. Healthy volunteers are also needed. Design: Participants with CS will have 3 DesmoSTs at least 48 hours apart. The procedure for each is as follows: They will limit their fluid intake the day before each test. They will have nothing to eat or drink for 12 hours before the test. For 1 of the tests, they will take a pill that contains a hormone (dexamethasone). They will take it around 11 pm the day before the test. Desmo is given through a tube attached to a needle inserted into a vein. Blood will be drawn a total of 6 times before and after the desmo is given. Healthy volunteers will have 4 DesmoSTs. These will be 2 to 14 days apart. All participants will have follow-up visits 3 to 5 days after each test. These visits may be by phone.
Recruiting1 award Phase 22 criteria
More about Lynnette K Nieman, MD
Clinical Trial Related11 years of experience running clinical trials · Led 3 trials as a Principal Investigator · 3 Active Clinical TrialsTreatments Lynnette K Nieman, MD has experience with
- 18F-DOPA
- 68Ga-DOTATATE
- DOTATATE PET-CT
- F-DOPA PET CT
- Desmopressin
- Dexamethasone
Breakdown of trials Lynnette K Nieman, MD has run
Cushing's Syndrome
Adrenocorticotropic Hormone
Liver Disease
ACTH Syndrome
Cushing's Disease
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Lynnette K Nieman, MD specialize in?
Lynnette K Nieman, MD focuses on Cushing's Syndrome and Adrenocorticotropic Hormone. In particular, much of their work with Cushing's Syndrome has involved treating patients, or patients who are undergoing treatment.
Is Lynnette K Nieman, MD currently recruiting for clinical trials?
Yes, Lynnette K Nieman, MD is currently recruiting for 3 clinical trials in Bethesda Maryland. If you're interested in participating, you should apply.
Are there any treatments that Lynnette K Nieman, MD has studied deeply?
Yes, Lynnette K Nieman, MD has studied treatments such as 18F-DOPA, 68Ga-DOTATATE, DOTATATE PET-CT.
What is the best way to schedule an appointment with Lynnette K Nieman, MD?
Apply for one of the trials that Lynnette K Nieman, MD is conducting.
What is the office address of Lynnette K Nieman, MD?
The office of Lynnette K Nieman, MD is located at: National Institutes of Health (NIH) - National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, Maryland 20892 United States. This is the address for their practice at the National Institutes of Health (NIH) - National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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