Dr. Marlana Orloff, MD
Claim this profileThomas Jefferson University
Studies Skin Cancer
Studies Uveal Melanoma
10 reported clinical trials
19 drugs studied
Area of expertise
1Skin Cancer
Stage IV
HLA-A negative
GNAQ positive
2Uveal Melanoma
Stage IV
HLA-A negative
GNAQ positive
Affiliated Hospitals
Clinical Trials Marlana Orloff, MD is currently running
Darovasertib + Crizotinib
for Uveal Melanoma
This trial is testing a new drug combination (IDE196 and crizotinib) on patients with a specific type of eye cancer that has spread. The goal is to see if this combination can stop or slow down the cancer better than other treatments. Crizotinib has been used in treating various cancers with ALK gene rearrangements, showing high response rates.
Recruiting1 award Phase 2 & 38 criteria
APG-115 + Pembrolizumab
for Skin Cancer
This study aims to assess the safety, tolerability, pharmacokinetics, and preliminary efficacy of APG-115, an MDM2 inhibitor, either alone or in combination with pembrolizumab, a programmed cell death protein-1 (PD-1) inhibitor, in patients with metastatic melanomas or advanced solid tumors. Our hypothesis is that restoration of the immune response concomitant to inhibition of the MDM2 pathway (which restores p53 functions) may promote cancer cell death, leading to effective anticancer therapy.
Recruiting1 award Phase 1 & 213 criteria
More about Marlana Orloff, MD
Clinical Trial Related1 year of experience running clinical trials · Led 10 trials as a Principal Investigator · 5 Active Clinical TrialsTreatments Marlana Orloff, MD has experience with
- Pembrolizumab
- IDE196
- Crizotinib
- Ipilimumab
- Nivolumab
- SD-101
Breakdown of trials Marlana Orloff, MD has run
Skin Cancer
Uveal Melanoma
Eye Cancer
Melanoma
Non-Small Cell Lung Cancer
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Marlana Orloff, MD specialize in?
Marlana Orloff, MD focuses on Skin Cancer and Uveal Melanoma. In particular, much of their work with Skin Cancer has involved Stage IV patients, or patients who are HLA-A negative.
Is Marlana Orloff, MD currently recruiting for clinical trials?
Yes, Marlana Orloff, MD is currently recruiting for 4 clinical trials in Philadelphia Pennsylvania. If you're interested in participating, you should apply.
Are there any treatments that Marlana Orloff, MD has studied deeply?
Yes, Marlana Orloff, MD has studied treatments such as Pembrolizumab, IDE196, Crizotinib.
What is the best way to schedule an appointment with Marlana Orloff, MD?
Apply for one of the trials that Marlana Orloff, MD is conducting.
What is the office address of Marlana Orloff, MD?
The office of Marlana Orloff, MD is located at: Thomas Jefferson University, Philadelphia, Pennsylvania 19107 United States. This is the address for their practice at the Thomas Jefferson University.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.