Dr. Nader Pouratian

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UT Southwestern Medical Center

Studies Depression
Studies Major Depressive Disorder
5 reported clinical trials
4 drugs studied

Affiliated Hospitals

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UT Southwestern Medical Center

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University Of Texas Southwestern Medical Center

Clinical Trials Nader Pouratian is currently running

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Deep Brain Stimulation Surgery

for Treatment Resistant Depression

Treatment resistant depression remains a major problem for individuals and society. Surgical procedures may provide relief for some of these patients. The most frequently considered surgical approach is deep brain stimulation (DBS) of a part of the brain called the subcallosal cingulate region. However, the effectiveness and safety is not well established. The investigators will use a novel approach using advanced imaging technique (magnetic resonance tractography) to evaluate the feasibility and safety of this surgical approach. An innovative method for the definition of DBS target will be applied that redefines the concept of targeting as one of targeting a symptomatic network rather than a structural brain region using subject-based brain anatomy to define the target location. The correlation between imaging findings at baseline with the mood score changes at different time points of the study will be investigated.

Recruiting

1 award

N/A

11 criteria

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Deep Brain Stimulation

for Depression

The goal of the study is to address the unmet need of TRD patients by identifying brain networks critical for treating depression and to use next generation precision DBS with steering capability to engage these targeted networks. The study's goal will be achieved through 3 specific aims: 1. Demonstrate device capability to selectively and predictably engage distinct brain networks 2. Delineate depression-relevant networks and demonstrate behavioral changes with network-targeted stimulation 3. Demonstrate that chronic DBS using steered, individualized targeting is feasible and safe for reducing depressive symptoms

Recruiting

1 award

N/A

13 criteria

More about Nader Pouratian

Clinical Trial Related

3 years of experience running clinical trials · Led 5 trials as a Principal Investigator · 4 Active Clinical Trials

Treatments Nader Pouratian has experience with

  • Deep Brain Stimulation
  • Abbott Laboratories Infinity™ Implantable Deep Brain Stimulation System
  • Deep Brain Stimulation Of The Subgenus Cingulate Cortex
  • Directional Deep Brain Stimulation

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