Dr. Nicole P. Chappell
Claim this profileGeorge Washington University Medical Center
Studies Serous Cystadenocarcinoma
Studies Ovarian Cancer
5 reported clinical trials
16 drugs studied
Area of expertise
1Serous Cystadenocarcinoma
Stage II
Stage III
Stage IV
2Ovarian Cancer
BRCA1 positive
Stage II
Stage III
Affiliated Hospitals
Clinical Trials Nicole P. Chappell is currently running
Letrozole +/- Chemotherapy
for Ovarian Cancer
This phase III trial studies how well letrozole with or without paclitaxel and carboplatin works in treating patients with stage II-IV low-grade serous carcinoma of the ovary, fallopian tube, or peritoneum. Letrozole is an enzyme inhibitor that lowers the amount of estrogen made by the body which in turn may stop the growth of tumor cells that need estrogen to grow. Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving letrozole alone or in combination with paclitaxel and carboplatin works better in treating patients with low-grade serous carcinoma of the ovary, fallopian tube, or peritoneum compared to paclitaxel and carboplatin without letrozole.
Recruiting2 awards Phase 318 criteria
Herceptin Hylecta or Phesgo + Chemotherapy
for Uterine Cancer
This phase II/III trial tests whether adding trastuzumab and hyaluronidase-oysk (Herceptin HylectaTM) or pertuzumab, trastuzumab and hyaluronidase-zzxf (PhesgoTM) to the usual chemotherapy (paclitaxel and carboplatin) works to shrink tumors in patients with HER2 positive endometrial serous carcinoma or carcinosarcoma. Trastuzumab and pertuzumab are monoclonal antibodies and forms of targeted therapy that attach to specific molecules (receptors) on the surface of tumor cells, known as HER2 receptors. When trastuzumab or pertuzumab attach to HER2 receptors, the signals that tell the cells to grow are blocked and the tumor cell may be marked for destruction by the body's immune system. Hyaluronidase is an endoglycosidase. It helps to keep pertuzumab and trastuzumab in the body longer, so that these medications will have a greater effect. Hyaluronidase also allows trastuzumab and trastuzumab/pertuzumab to be given by injection under the skin and shortens their administration time compared to trastuzumab or pertuzumab alone. Paclitaxel is a taxane and in a class of medications called antimicrotubule agents. It stops cancer cells from growing and dividing and may kill them. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of tumor cells. Giving Herceptin Hylecta or Phesgo in combination with paclitaxel and carboplatin may shrink the tumor and prevent the cancer from coming back in patients with HER2 positive endometrial serous carcinoma or carcinosarcoma.
Recruiting1 award Phase 2 & 3
More about Nicole P. Chappell
Clinical Trial Related5 years of experience running clinical trials · Led 5 trials as a Principal Investigator · 4 Active Clinical TrialsTreatments Nicole P. Chappell has experience with
- Bilateral Salpingectomy With Oophorectomy
- Bilateral Salpingectomy
- Olaparib
- Cediranib Maleate
- Capivasertib
- Durvalumab
Breakdown of trials Nicole P. Chappell has run
Serous Cystadenocarcinoma
Ovarian Cancer
Endometrial Carcinoma
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Nicole P. Chappell specialize in?
Nicole P. Chappell focuses on Serous Cystadenocarcinoma and Ovarian Cancer. In particular, much of their work with Serous Cystadenocarcinoma has involved Stage II patients, or patients who are Stage III.
Is Nicole P. Chappell currently recruiting for clinical trials?
Yes, Nicole P. Chappell is currently recruiting for 4 clinical trials in Washington District of Columbia. If you're interested in participating, you should apply.
Are there any treatments that Nicole P. Chappell has studied deeply?
Yes, Nicole P. Chappell has studied treatments such as Bilateral Salpingectomy with Oophorectomy, Bilateral Salpingectomy, Olaparib.
What is the best way to schedule an appointment with Nicole P. Chappell?
Apply for one of the trials that Nicole P. Chappell is conducting.
What is the office address of Nicole P. Chappell?
The office of Nicole P. Chappell is located at: George Washington University Medical Center, Washington, District of Columbia 20037 United States. This is the address for their practice at the George Washington University Medical Center.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.