Nisha A Mohindra: Faculty Profiles ...

Dr. Nisha A. Mohindra

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Northwestern University

Studies Lung Cancer
Studies Non-Small Cell Lung Cancer
10 reported clinical trials
19 drugs studied

Area of expertise

1

Lung Cancer

Nisha A. Mohindra has run 8 trials for Lung Cancer. Some of their research focus areas include:

Stage III
Stage IV
Stage II
2

Non-Small Cell Lung Cancer

Nisha A. Mohindra has run 6 trials for Non-Small Cell Lung Cancer. Some of their research focus areas include:

Stage III
Stage II
Stage IV

Affiliated Hospitals

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Northwestern University

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Northwestern Medicine Lake Forest Hospital

Clinical Trials Nisha A. Mohindra is currently running

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Osimertinib + Bevacizumab

for Lung Cancer

This phase III trial compares the effect of bevacizumab and osimertinib combination vs. osimertinib alone for the treatment of non-small cell lung cancer that has spread outside of the lungs (stage IIIB-IV) and has a change (mutation) in a gene called EGFR. The EGFR protein is involved in cell signaling pathways that control cell division and survival. Sometimes, mutations in the EGFR gene cause EGFR proteins to be made in higher than normal amounts on some types of cancer cells. This causes cancer cells to divide more rapidly. Osimertinib may stop the growth of tumor cells by blocking EGFR that is needed for cell growth in this type of cancer. Bevacizumab is in a class of medications called antiangiogenic agents. It works by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Giving osimertinib with bevacizumab may control cancer for longer and help patients live longer as compared to osimertinib alone.

Recruiting

2 awards

Phase 3

31 criteria

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Tazemetostat + Topotecan + Pembrolizumab

for Small Cell Lung Cancer

This phase I trial tests the safety, side effects, and best dose of tazemetostat in combination with topotecan and pembrolizumab in treating patients with small cell lung cancer that has come back after a period of improvement (recurrent). Tazemetostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Chemotherapy drugs, such as topotecan, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving tazemetostat in combination with topotecan and pembrolizumab may shrink or stabilize recurrent small cell lung cancer.

Recruiting

1 award

Phase 1

19 criteria

More about Nisha A. Mohindra

Clinical Trial Related

5 years of experience running clinical trials · Led 10 trials as a Principal Investigator · 3 Active Clinical Trials

Treatments Nisha A. Mohindra has experience with

  • Carboplatin
  • Pembrolizumab
  • Paclitaxel
  • Pemetrexed
  • Atezolizumab
  • Cisplatin

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