Dr. Sophie Grigoriadis, MD
Claim this profileSunnybrook Health Sciences Centre
Studies Depression Treatment
Studies Major Depression
2 reported clinical trials
5 drugs studied
Affiliated Hospitals
Clinical Trials Sophie Grigoriadis, MD is currently running
Dietary & Supplement Intervention
for Perinatal Depression & Anxiety
Perinatal depression and anxiety (PDA) are the leading causes of maternal mortality in developed countries. Women with a history of depression have a 20 fold higher risk of PDA at subsequent pregnancies. The adverse outcomes extend beyond maternal well-being to long-term deficits in children and families. The gut-brain axis is a newly recognized key player in mental health disorders. Specifically, the microbial composition of the gut along with their metabolites are directly involved in disease onset and course. Recent clinical studies have identified diet as the most powerful environmental factor in manipulating gut microbiome. Given vulnerability and resistance of pregnant women to pharmacotherapy, particularly in those with a predisposition to mood disorders, as well as pregnant women's high motivation and commitment to improving gestational diet, a dietary/supplemental intervention to 'optimize' gut microbiome, is a favored approach in disease management. The study investigators aim to exploit microbial responsiveness to diet together with this maternal motivation, to alter the risk and severity of a universal public health concern that has dire and long-term consequences for new moms and their children. The investigators of this trial, will first study the challenges in pursuing a study aimed at changing the microbiome of pregnant women with a history of mood disorders. Pregnant women in their second trimester will be recruited. Each will be assigned or randomized to one of four groups that will use a combination of diet, supplementation with probiotics, fish oil or no intervention. Each participant will meet with the study team virtually every 3 months until 1 year after delivery. At each study visit participants will be required to complete some questionnaires about their food intake, mood, and other health related measures and will provide a stool sample using the stool collection kits provided. The findings from this study will help strategize for a larger study that will allow for comparison of the effects of diet, and/or supplementation with Omega-3 Fatty Acids (O3FA) and probiotics on the microbiome and the onset and severity of PDA.
Recruiting1 award Phase 2 & 36 criteria
At-Home tDCS
for Depression in Pregnancy
This is a randomized, sham-controlled trial to determine whether treatment with transcranial direct current stimulation (tDCS) is superior to a sham condition at reducing the symptoms of depression in pregnant people with moderate to severe depression. The study aims to enrol 156 participants across all sites. Data collection occurs at baseline, immediately after treatment, every 4 weeks during pregnancy and 4-, 12-, 26- and 52-weeks postpartum
Recruiting0 awards N/A
More about Sophie Grigoriadis, MD
Clinical Trial Related1 year of experience running clinical trials · Led 2 trials as a Principal Investigator · 2 Active Clinical TrialsTreatments Sophie Grigoriadis, MD has experience with
- Active TDCS
- Sham TDCS
- Diet Quality
- Fish Oil
- Probiotics
Breakdown of trials Sophie Grigoriadis, MD has run
Depression Treatment
Major Depression
Postpartum Depression
Pregnancy or Postpartum
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Sophie Grigoriadis, MD specialize in?
Sophie Grigoriadis, MD focuses on Depression Treatment and Major Depression. In particular, much of their work with Depression Treatment has involved treating patients, or patients who are undergoing treatment.
Is Sophie Grigoriadis, MD currently recruiting for clinical trials?
Yes, Sophie Grigoriadis, MD is currently recruiting for 2 clinical trials in Toronto Ontario. If you're interested in participating, you should apply.
Are there any treatments that Sophie Grigoriadis, MD has studied deeply?
Yes, Sophie Grigoriadis, MD has studied treatments such as active tDCS, sham tDCS, Diet Quality.
What is the best way to schedule an appointment with Sophie Grigoriadis, MD?
Apply for one of the trials that Sophie Grigoriadis, MD is conducting.
What is the office address of Sophie Grigoriadis, MD?
The office of Sophie Grigoriadis, MD is located at: Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5 Canada. This is the address for their practice at the Sunnybrook Health Sciences Centre.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.