Dr. William T. Cash

About William T. Cash

Education:

• Obtained an MD from the University of Alabama School of Medicine, Birmingham, Alabama.
• Holds a Bachelor of Science in Chemistry from Auburn University.
• Earned an MSc in Clinical Research from Emory University School of Medicine, Atlanta, Georgia.

Experience:

• Completed a Residency in Pediatrics at the University of Arkansas for Medical Sciences/Arkansas Children's Hospital, Little Rock, Arkansas.
• Undertook a Fellowship in Pediatric Hematology/Oncology at Emory University School of Medicine, Atlanta, Georgia.
• Serves as an Assistant Professor of Pediatrics in the Division of Pediatric Hematology/Oncology at Emory University.
• Appointed Medical Director for the Solid Tumor Program at the Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta.
• Acts as the Institutional Principal Investigator for the Children's Oncology Group (COG), focusing on pediatric solid tumors.

Area of expertise

Affiliated Hospitals

Children's Healthcare Of Atlanta - Egleston

Clinical Trials William T. Cash is currently running

Genetic Testing-Directed Therapy

for Pediatric Cancer

This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists that has been shown to prolong survival. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with genetic changes or abnormalities (mutations) may benefit more from treatment which targets their tumor's particular genetic mutation, and may help doctors plan better treatment for patients with solid tumors or non-Hodgkin lymphomas.

Recruiting1 award Phase 214 criteria

Dinutuximab + Chemotherapy

for High-Risk Neuroblastoma

This phase III trial tests how well the addition of dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy works for treating children with newly diagnosed high-risk neuroblastoma. Dinutuximab is a monoclonal antibody that binds to a molecule called GD2, which is found on the surface of neuroblastoma cells, but is not present on many healthy or normal cells in the body. When dinutuximab binds to the neuroblastoma cells, it helps signal the immune system to kill the tumor cells. This helps the cells of the immune system kill the cancer cells, this is a type of immunotherapy. When chemotherapy and immunotherapy are given together, during the same treatment cycle, it is called chemoimmunotherapy. This clinical trial randomly assigns patients to receive either standard chemotherapy and surgery or chemoimmunotherapy (chemotherapy plus dinutuximab) and surgery during Induction therapy. Chemotherapy drugs administered during Induction include, cyclophosphamide, topotecan, cisplatin, etoposide, vincristine, and doxorubicin. These drugs work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing or by stopping them from spreading. Upon completion of 5 cycles of Induction therapy, a disease evaluation is completed to determine how well the treatment worked. If the tumor responds to therapy, patients receive a tandem transplantation with stem cell rescue. If the tumor has little improvement or worsens, patients receive chemoimmunotherapy on Extended Induction. During Extended Induction, dinutuximab is given with irinotecan, temozolomide. Patients with a good response to therapy move on to Consolidation therapy, when very high doses of chemotherapy are given at two separate points to kill any remaining cancer cells. Following, transplant, radiation therapy is given to the site where the cancer originated (primary site) and to any other areas that are still active at the end of Induction. The final stage of therapy is Post-Consolidation. During Post-Consolidation, dinutuximab is given with isotretinoin, with the goal of maintaining the response achieved with the previous therapy. Adding dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy may be better at treating children with newly diagnosed high-risk neuroblastoma.

Recruiting2 awards Phase 37 criteria

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