Luvox vs Lexapro

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Table of Contents

Overview

Medication Information

Effectiveness

Dosage Information

Side Effects

Warnings and Precautions

Cost

Market Information

Overview

Medication Information

Effectiveness

Dosage Information

Side Effects

Warnings and Precautions

Cost

Market Information

Introduction

For patients dealing with obsessive-compulsive disorder (OCD), major depressive disorder (MDD), or other forms of anxiety, specific drugs that modify neurotransmitters in the brain can help manage persistent thoughts and repetitive behaviors. Lexapro and Luvox are two such medications often prescribed for these conditions. Each drug works on different neurotransmitters in the brain, but both have been shown to help control OCD symptoms and improve mood stability.

Luvox, also known as fluvoxamine, is a selective serotonin reuptake inhibitor (SSRI) primarily affecting levels of serotonin—a chemical messenger associated with mood regulation. On the other hand, Lexapro—also known as escitalopram—is not only an SSRI but has some impact on norepinephrine too. Both drugs aim to increase serotonin levels by blocking its reabsorption into neurons; however, they differ slightly in their side effects and interactions with other medicines.

Luvox vs Lexapro Side By Side

Attribute	Luvox	Lexapro
Brand Name	Luvox	Lexapro
Contraindications	Should not be taken with or shortly after MAO inhibitors.	Should not be taken with or shortly after MAO inhibitors.
Cost	For brand name, about $130 for 30 capsules (50 mg). For generic fluvoxamine, prices start from around $0.30 per day.	For brand name, about $400 for 60 tablets (10 mg). For generic escitalopram, costs range from $0.15 to $2 per day.
Generic Name	Fluvoxamine	Escitalopram
Most Serious Side Effect	Serotonin syndrome, visual disturbances, low sodium levels, severe nervous system reaction.	Increase in suicidal thoughts or worsening depression, serotonin syndrome.
Severe Drug Interactions	MAO inhibitors.	MAO inhibitors.
Typical Dose	50-300 mg/day, with 100 mg/day often being effective.	10-20 mg/day, starting at 10 mg/day.

What is Luvox?

Fluvoxamine (the generic name for Luvox) was one of the earliest drugs in the SSRI class of antidepressants, a significant advancement over the initial class known as tricyclic antidepressants (TCAs). Fluvoxamine got FDA approval initially in 1994. Luvox increases levels of free serotonin by inhibiting its reabsorption, effectively allowing it to remain in the brain for an extended period. It is usually prescribed for treating obsessive-compulsive disorder and social anxiety disorder. On the other hand, escitalopram (generic Lexapro), another SSRI, has a broader range of uses such as depression and generalized anxiety disorder along with fewer side effects than fluvoxamine due to its selective effect on serotonin reuptake and minor influence on norepinephrine and dopamine neurotransmitters.

What conditions is Luvox approved to treat?

Luvox is approved for the treatment of different mental health disorders:

Obsessive-compulsive disorder (OCD)
Social anxiety disorder
Major depressive disorder (MDD), although this usage is off-label in the US.

How does Luvox help with these illnesses?

Luvox, also known as fluvoxamine, helps manage conditions like depression and obsessive-compulsive disorder by increasing the amount of serotonin available in the synapses of the brain. It accomplishes this by inhibiting its reuptake into neurons, which allows serotonin levels to be maintained at higher concentrations for longer periods. Serotonin is a neurotransmitter - a chemical messenger within the brain and body - that plays a crucial role in mood regulation, cognition, memory, sleep patterns, hunger cravings and thermoregulation among other things. Individuals with depressive disorders or OCD typically have relatively lower levels of serotonin. Therefore, by augmenting these levels through selective serotonin reuptake inhibition (SSRI), Luvox can help alleviate negative symptoms associated with these conditions and help patients better manage their health issues.

What is Lexapro?

Lexapro, a brand name for escitalopram, is a selective serotonin reuptake inhibitor (SSRI) that elevates the mood by increasing levels of serotonin in the brain due to reduced reabsorption. This differs from drugs like Luvox as it does not have any significant effect on norepinephrine or dopamine neurotransmitters. Lexapro was first approved by the FDA in 2002 and has since been widely used to treat depression and generalized anxiety disorder. Its unique action on serotonin means its side-effect profile will differ slightly from other SSRIs, especially when compared with those such as Luvox which also act on different neurotransmitters. Common side effects may include drowsiness, sexual dysfunction and weight changes; however, it is less likely to cause sedation compared to some other antidepressants. The specific focus on serotonin can be particularly effective for patients who do not respond well to "typical" SSRI antidepressant drugs such as Luvox.

What conditions is Lexapro approved to treat?

Lexapro is approved for the treatment of:

Major depressive disorder (MDD)
Generalized anxiety disorder (GAD)

This medication has been widely recognized as a potent and effective treatment option, offering patients relief from persistent feelings of overwhelming anxiety or pervasive sadness. It's crucial to remember that Lexapro should be used under medical supervision, considering its potency and potential side effects.

How does Lexapro help with these illnesses?

Serotonin is a neurotransmitter that plays roles in many processes in the body, affecting mood regulation, digestion, sleep cycle and overall well-being. Similar to norepinephrine, low levels of serotonin have been implicated in depression and anxiety disorders. Lexapro (escitalopram) works by increasing the levels of serotonin available in the brain, thereby alleviating some symptoms associated with depression or anxiety. Its action primarily on serotonin makes it a selective serotonin reuptake inhibitor (SSRI). Since it has fewer side effects compared to other classes of antidepressants such as Luvox (fluvoxamine), which also affects other neurotransmitters like dopamine and noradrenaline along with serotonin; Lexapro can be preferred when a patient does not respond well to these typical SSRIs or may be combined with them for more comprehensive treatment.

How effective are both Luvox and Lexapro?

Both fluvoxamine (Luvox) and escitalopram (Lexapro) have proven effectiveness in treating patients with conditions such as depression and anxiety disorders, having been approved by the FDA. These two drugs act on the serotonin system but they do so differently which can lead to them being prescribed under different circumstances. The efficacy of Luvox and Lexapro in easing symptoms of depression was directly studied in a double-blind clinical trial; both drugs demonstrated similar efficiency at managing depressive symptoms along with comparable safety profiles.

A review conducted showed that fluvoxamine is effective from the first week of treatment at alleviating symptoms associated with obsessive-compulsive disorder (OCD), one of its primary indications for use. It has an overall favorable side effect profile compared to many other antidepressants, particularly older tricyclic antidepressants, however it may be more likely than some other SSRIs to cause gastrointestinal disturbances. Fluvoxamine is well-tolerated even among elderly populations suffering from OCD or major depressive disorder.

On the other hand, a 2018 meta-analysis indicated that escitalopram seems to be more effective than placebo in treating generalized anxiety disorder and social phobia, as well as maintaining remission in patients suffering from major depressive disorder. While considered a first-line treatment option for these conditions due to its efficacy and tolerability profile, some clinicians prefer using escitalopram alongside cognitive behavioral therapy rather than as stand-alone treatment when possible for best outcomes. Escitalopram tends not to contribute significantly towards weight gain or sexual dysfunction making it ideal for long-term management especially among individuals who are concerned about these potential side effects.

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At what dose is Luvox typically prescribed?

Oral dosages of Luvox range from 50-300 mg/day, however, research suggests that a dosage of 100 mg/day is often effective in treating obsessive-compulsive disorder (OCD) and major depressive disorder (MDD) in many individuals. Children and adolescents may be started on a lower dose such as 25 mg/day. In both populations, the dosage can be increased gradually over several weeks if there is no noticeable improvement. The maximum daily dosage should not exceed 300 mg under any circumstances. On the other hand, Lexapro's suggested oral dosages range from 10-20mg/day for adults with MDD or Generalized Anxiety Disorder (GAD). Adolescents aged between 12 to17 years might start on a dose of about 10mg per day. If necessary, doses can be increased after at least one week but should not exceed the maximum limit of 20mg per day.

At what dose is Lexapro typically prescribed?

Lexapro treatment is typically initiated at a dose of 10 mg/day. If necessary, the dosage can be increased to 20 mg/day, administered as one daily dose in the morning or evening. The full effects may not be seen until after a few weeks of treatment, so it's essential to continue taking Lexapro even if there are no immediate noticeable changes. It's also important to remember that this medication must be taken consistently and at around the same time each day for optimal results. The maximum recommended dose is 20 mg per day; exceeding this amount could lead to an increased risk of side effects without providing additional therapeutic benefits.

What are the most common side effects for Luvox?

The common side effects of Luvox (Fluvoxamine) and Lexapro (Escitalopram) are similar as they both belong to the same class of drugs - Selective Serotonin Reuptake Inhibitors. However, there may be some differences. Common side effects of Luvox can include:

Nausea
Sleepiness/drowsiness or insomnia
Sweating
Dry mouth
Constipation or diarrhea
Loss of appetite
Weakness and fatigue
Abnormal dreams

Lexapro's common side effects might comprise:

Nausea
Dry mouth
Dizziness or light-headedness
Insomnia or excessive sleepiness/drowsiness
-Tremors -Anxiety and restlessness/ nervousness
-Sweating
-Decreased sex drive, difficulties in achieving orgasm, impotence in men
-Diarrhea

While these lists do not cover all potential side-effects, anyone experiencing severe symptoms should contact their healthcare provider immediately.

abstract image of a patient experiencing side effect

Are there any potential serious side effects for Luvox?

While Luvox and Lexapro may be similar in their intended uses, they can have different side effects. When taking Luvox, some serious side effects to look out for are:

Any signs of worsening depression or suicidal thoughts.
Indications of an allergic reaction such as hives; difficulty breathing; swelling of your face, lips, tongue, or throat
Visual disturbances including blurred vision and seeing halos around lights;
Cardiovascular symptoms like fast or pounding heartbeats, fluttering in your chest area and feeling like you might faint;
Low sodium levels - this can present with headache, confusion, slurred speech severe weakness vomiting loss of coordination feeling unsteady
Severe nervous system reaction which could involve very stiff (rigid) muscles high fever sweating confusion fast uneven heartbeat tremors feeling like passing out.

Lastly the patient needs to check for any symptoms suggestive serotonin syndrome: agitation hallucinations fever sweating shivering increased heart rate muscle stiffness twitching loss coordination nausea vomiting diarrhea. If you experience any one these aforementioned symptoms while on Luvox seek immediate medical attention.

What are the most common side effects for Lexapro?

Lexapro, another option for managing mental health conditions such as depression and anxiety disorder, has some potential side effects to consider:

Dry mouth
Nausea, constipation
Sweating
Sleep problems (insomnia)
Fatigue, drowsiness
Increased appetite and subsequent weight gain
Dizziness or fainting spells
Sexual dysfunction While these are possible symptoms you may experience while on Lexapro, it's important to remember that not everyone will have the same reactions. Always consult with your doctor about any concerns so they can tailor a treatment plan that works best for you.

Are there any potential serious side effects for Lexapro?

Lexapro, while generally considered safe and effective for treating depression and anxiety disorders, can occasionally result in serious side effects. These could include:

Signs of an allergic reaction such as skin rash or hives, itching or swelling (especially of the face, lips, tongue), severe dizziness or difficulty breathing
Increase in suicidal thoughts or worsening depression
Unusual changes in behavior including agitation, restlessness or risk-taking behavior
Hallucinations and/or confusion
Severe nausea/vomiting/diarrhea might indicate serotonin syndrome
Changes to vision including blurred vision
Pounding heartbeat/ fast-fluttering heartbeat; chest pain indicating possible heart issues.

If you experience any of these symptoms while taking Lexapro, it is imperative that you seek immediate medical attention.

Contraindications for Luvox and Lexapro?

Both Luvox and Lexapro, like many other antidepressant medications, may heighten symptoms of depression in some individuals. If you observe your depression becoming more severe or note an escalation in thoughts of suicide or self-harm, it is crucial that you seek immediate medical attention.

Neither Luvox nor Lexapro should be taken if you are using or have recently discontinued monoamine oxidase (MAO) inhibitors. It's essential to inform your healthcare provider about all the medications you're currently taking; MAOIs require a washout period of around 5 weeks to eliminate from the system entirely to prevent harmful interactions with either Luvox or Lexapro.

How much do Luvox and Lexapro cost?

For the brand name versions of these drugs:

The price of 60 tablets of Lexapro (10 mg) averages around $400, which works out to $13–26/day, depending on your dose.
The price of 30 capsules of Luvox (50 mg) averages is about $130, working out to approximately $4.33/day.

Thus, if you are in the higher dosage range for Lexapro (i.e., 20 mg/day or higher), then brand-name Luvox is less expensive on a per-day treatment basis. Please note that cost should not be a primary consideration in determining which of these drugs is right for you.

For the generic versions of Luvox (fluvoxamine) and Lexapro (escitalopram), costs are significantly lower:

Escitalopram (10 mg tablets) is available in packs from 5 up to 500 tablets with approximate costs ranging from $0.15 to $2 per day depending on dosage and quantity purchased initially.
Fluvoxamine comes in packages varying between 10 and hundreds of capsules/tablets at strengths starting from as low as 25mg going upto 100mg. Prices can vary widely but typically start from around $0.30 per day if bought in larger quantities upfront and can go up to approximately $1.80/day based upon strength/dosage required.

Popularity of Luvox and Lexapro

Fluvoxamine, in generic form or under the brand name Luvox, was estimated to have been prescribed to about 1 million people in the US in 2020. Fluvoxamine accounted for just over 2% of SSRI prescriptions in the US. However, it appears to be most commonly used as an atypical antidepressant (not classified as an SSRI) especially for its off-label use for obsessive-compulsive disorder (OCD). The prevalence of fluvoxamine has been generally stable since 2013.

Escitalopram, including brand versions such as Lexapro, was prescribed to approximately 13 million people in the USA in 2020. In the US, escitalopram accounts for nearly a quarter of all SSRI prescriptions and just over 10% of overall antidepressant prescriptions. The prevalence of Escitalopram has seen a steady increase over the last decade due largely to its improved side effect profile compared to other SSRIs.

Conclusion

Both Luvox (fluvoxamine) and Lexapro (escitalopram) have a long-standing record of usage in patients with depression and anxiety disorders, backed by numerous clinical studies indicating their effectiveness over placebo treatments. They belong to the class of selective serotonin reuptake inhibitors (SSRIs), working primarily on increasing brain levels of serotonin, but they are used under different circumstances.

Luvox is often prescribed for obsessive-compulsive disorder (OCD) and social phobia due to its unique ability among SSRIs to interact with sigma-1 receptors which aids in reducing obsessive-compulsive symptoms. On the other hand, Lexapro is considered a first-line treatment option for major depressive disorder and generalized anxiety disorder.

Both drugs are available in generic forms, offering significant cost savings especially for those paying out-of-pocket. Both may require an adjustment period - it can take several weeks before full benefits are observed.

The side effect profile between these two medications shows some similarities; both being generally well-tolerated but having potential for typical SSRI-related side effects such as sexual dysfunction or weight changes. As always, patients must closely monitor their moods while starting or changing dosages of these medications, seeking immediate medical help if they notice worsening depression or begin to have thoughts about self-harm.

Refrences

Stein, D., Andersen, H. F., & Goodman, W. (2005, April 1). Escitalopram for the Treatment of GAD: Efficacy Across Different Subgroups and Outcomes. Annals of Clinical Psychiatry. Portico.http://doi.org/10.1080/10401230590932335
Kusturica, J., Zulić, I., Loga-Zec, S., Mulabegović, N., Loga, S., & Kapić, E. (2002, February 20). Frequency and characteristics of side effects associated with antidepressant drugs. Bosnian Journal of Basic Medical Sciences. Association of Basic Medical Sciences of FBIH.http://doi.org/10.17305/bjbms.2002.3575
Aronson, S., & Delgado, P. (2004). Escitalopram. Drugs of Today. Portico.http://doi.org/10.1358/dot.2004.40.2.799424
Skandali, N., Rowe, J. B., Voon, V., Deakin, J. B., Cardinal, R. N., Cormack, F., … Sahakian, B. J. (2018, September 26). Dissociable effects of acute SSRI (escitalopram) on executive, learning and emotional functions in healthy humans. Neuropsychopharmacology. Springer Science and Business Media LLC.http://doi.org/10.1038/s41386-018-0229-z
Bolton, J. M., Dahl, M., Sareen, J., Enns, M. W., Leslie, W. D., Collins, D. M., & Alessi-Severini, S. (2012, April). A Population-Based Study of the Use of Selective Serotonin Reuptake Inhibitors before and after Introduction of Generic Equivalents. The Canadian Journal of Psychiatry. SAGE Publications.http://doi.org/10.1177/070674371205700405
Milanfranchi, A., Ravagli, S., Lensi, P., Marazziti, D., & Cassano, G. B. (1997, May). A double-blind study of fluvoxamine and clomipramine in the treatment of obsessive-compulsive disorder. International Clinical Psychopharmacology. Ovid Technologies (Wolters Kluwer Health).http://doi.org/10.1097/00004850-199705000-00002