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Neurotoxin

BOTOX for Epilepsy

Phase 4
Recruiting
Research Sponsored by Beth Israel Deaconess Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age: 18-85 years, inclusive
Pharmaco-resistant focal epilepsy with >3 seizures a month
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 150days
Awards & highlights

Study Summary

This trial aims to see if BOTOX injections can reduce the frequency and severity of seizures in people with epilepsy.

Who is the study for?
This trial is for adults aged 18-85 with pharmaco-resistant focal epilepsy experiencing more than three seizures a month. Participants should not have had recent cranial surgery, changes in epilepsy medication, or botulinum toxin injections recently. Pregnant individuals or those at risk of pregnancy must use contraception.Check my eligibility
What is being tested?
The study tests if BOTOX (OnabotulinumtoxinA) injections can reduce the frequency and severity of seizures in people with epilepsy. It's based on similarities between migraine and epilepsy treatments.See study design
What are the potential side effects?
Possible side effects include reactions at the injection site, muscle weakness, headaches, eyelid drooping, bronchitis, and upper respiratory tract infections. Side effects vary from person to person.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 85 years old.
Select...
I have epilepsy with more than 3 seizures a month that doesn't respond to medication.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~150days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 150days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Seizures, Focal
Generalized seizures
Secondary outcome measures
• Improvement in quality-of-life metrics
• Reduction in net cortical excitability metrics
Seizures

Trial Design

1Treatment groups
Experimental Treatment
Group I: Botox therapy effects on seizureExperimental Treatment1 Intervention

Find a Location

Who is running the clinical trial?

Beth Israel Deaconess Medical CenterLead Sponsor
839 Previous Clinical Trials
13,010,401 Total Patients Enrolled
AbbVieIndustry Sponsor
972 Previous Clinical Trials
506,100 Total Patients Enrolled
~13 spots leftby Dec 2025
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