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Nasonex vs Qnasl
Introduction
For patients dealing with nasal allergy symptoms, certain drugs that work by reducing inflammation in the nasal passages can help manage sneezing, itching, and congestion. Nasonex and Qnasl are two such medications often prescribed for these conditions. They each have different mechanisms of delivery but both provide relief from nasal allergy symptoms. Nasonex (mometasone) is a corticosteroid that works by reducing swelling and inflammation inside the nose. On the other hand, Qnasl (beclomethasone) also belongs to the corticosteroid family and it functions similarly, albeit delivered as a dry nasal aerosol rather than an aqueous spray like Nasonex.
Nasonex vs Qnasl Side By Side
| Attribute | Nasonex | Qnasl |
|---|---|---|
| Brand Name | Nasonex | Qnasl |
| Contraindications | Should not be used if there is an untreated active infection affecting the nose or throat. | Should not be used if there is an untreated active infection affecting the nose or throat. |
| Cost | Around $240 for a 17 g bottle (120 sprays), approximately $8/day | A canister with approximately 120 doses costs about $200–$250, approximately $7–$9/day. |
| Generic Name | Mometasone Furoate | Beclomethasone Dipropionate |
| Most Serious Side Effect | Severe allergic reactions, vision problems, signs of a hormonal disorder, severe nosebleeds, sores in the nose that won't heal, wheezing, trouble breathing, vision problems, fever, chills, body aches. | Signs of an allergic reaction, flu-like symptoms, nosebleeds or redness in the nose, sores or white patches inside or around your nose, blurred vision, eye pain, irregular heartbeats, changes in behavior and mood swings. |
| Severe Drug Interactions | Not specifically mentioned, but as with all medications, it's important to consult with a healthcare provider for a comprehensive understanding. | Not specifically mentioned, but as with all medications, it's important to consult with a healthcare provider for a comprehensive understanding. |
| Typical Dose | For adults and adolescents over 12 years old, start at two sprays in each nostril once a day (200 micrograms per day). Children between the ages of 2-11 should start with one spray in each nostril per day. | For adults and children 12 years of age and older, start with two sprays in each nostril once daily (320 mcg/day). Children between the ages of 4 to 11 years old, the usual starting dose is one spray in each nostril once daily (80mcg). |
What is Nasonex?
Mometasone furoate (the generic name for Nasonex) is a corticosteroid nasal spray that was a significant addition to the first class of allergy treatment drugs. It was initially approved by the FDA in 1997. Nasonex works by reducing inflammation and swelling in the nose, effectively alleviating symptoms like runny or stuffy nose, sneezing, and itching caused by year-round or seasonal allergies. Beclomethasone dipropionate (the generic name for Qnasl), on the other hand, is another corticosteroid nasal spray used for similar purposes but has a different chemical structure and may have slightly different effects on individuals based on their unique physiology. Both medications are effective at treating allergic rhinitis; however, they differ slightly regarding dosage frequency and potential side effects due to their distinct formulations.
What conditions is Nasonex approved to treat?
Nasonex and Qnasl are both approved for the treatment of various nasal symptoms associated with:
- Seasonal allergic rhinitis, also known as hay fever
- Perennial allergies which occur year-round
- Nasal congestion associated with seasonal allergic rhinitis in adults and pediatric patients.
In addition to these conditions, Nasonex is also approved for the prophylaxis of nasal symptoms of seasonal allergic rhinitis in adult and adolescent patients 12 years or older.
How does Nasonex help with these illnesses?
Nasonex helps to manage symptoms of allergic rhinitis by reducing inflammation in the nasal passages. It does this with its active ingredient, mometasone furoate, a corticosteroid that suppresses the body's immune response, reducing swelling and irritation. Allergic reactions trigger an overactive immune response which can lead to common allergy symptoms such as sneezing, runny nose, itchy or watery eyes and sinus discomfort. By suppressing this reaction, Nasonex effectively reduces these symptoms and provides relief for patients suffering from allergies.
Qnasl operates on similar principles but uses beclomethasone dipropionate as its active component. Like mometasone furoate found in Nasonex, beclomethasone also works by inhibiting the inflammatory responses caused by allergens - providing effective relief from allergic rhinitis symptoms. However, different individuals may respond differently to each medication due to individual factors like age or general health condition; hence it is essential to consult a healthcare provider before choosing between these medications.
What is Qnasl?
Qnasl is a brand name for beclomethasone, which is a corticosteroid that helps to prevent the release of substances in the body that cause inflammation. Qnasl works by reducing swelling and irritation in your nasal passages, providing relief from symptoms such as congestion, sneezing, itching or runny nose caused by seasonal or year-round allergies. It was first approved by the FDA in 2012. Unlike Nasonex (mometasone), Qnasl does not have any known effect on serotonin reuptake inhibition. This means its side-effect profile differs notably from medications like Nasonex; particularly it doesn't induce sedation or lead to weight gain and sexual dysfunction - common side effects associated with drugs impacting serotonin levels like some SSRIs do. The effects of Qnasl can be beneficial for treating allergic reactions, especially in patients who do not respond well to other typical allergy medicines like Nasonex.
What conditions is Qnasl approved to treat?
Qnasl is an approved nasal aerosol corticosteroid used for the treatment of:
- Seasonal allergic rhinitis in patients aged 4 years and older
- Perennial allergic rhinitis in people aged 12 years and older
It helps to reduce inflammation caused by allergies, thus alleviating symptoms like sneezing, itching, runny nose, or congestion.
How does Qnasl help with these illnesses?
Beclomethasone, the active ingredient in Qnasl, is a corticosteroid that helps to reduce inflammation and swelling in the nasal passages. It plays an important role in managing symptoms of seasonal or perennial allergies such as sneezing, itching, runny nose and congestion. Similar to mometasone furoate contained in Nasonex, its action primarily revolves around decreasing inflammation by suppressing migration of polymorphonuclear leukocytes and reversing capillary permeability. However, it's worth noting that Qnasl may have a slight edge over Nasonex due to its unique aerosol delivery system which allows for more consistent dosing with each spray. This could potentially lead to better symptom control for patients suffering from allergic rhinitis who don't respond well enough to other intranasal corticosteroids like Nasonex.
How effective are both Nasonex and Qnasl?
Both mometasone furoate (Nasonex) and beclomethasone dipropionate (Qnasl) have established histories of success in treating patients with allergic rhinitis, and they were initially approved by the FDA only a few years apart. Since they act on different corticosteroid receptors, they may be prescribed under different circumstances. The effectiveness of Nasonex and Qnasl in alleviating symptoms of allergy was directly studied several times; both drugs exhibited similar efficacy in managing symptoms such as sneezing, itching, runny nose, congestion as well as promising safety profiles.
A 2008 study demonstrated that Nasonex is effective from the first day of treatment for seasonal allergies. It has a favorable side effect profile compared to older nasal steroids due to its lower absorption into the body reducing potential systemic effects. It can also be used by children above two years old making it versatile across age groups.
A 2014 review indicated that Qnasl seems to offer rapid onset relief against allergic symptoms and offers once daily dosing convenience which improves patient compliance. Nonetheless, Qnasl is often considered after other nasal steroids have been tried or are unsuitable due to individual needs or preferences because it comes as a dry aerosol spray rather than an aqueous solution like most other nasal sprays including Nasonex.
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At what dose is Nasonex typically prescribed?
Nasal dosages of Nasonex for adults and adolescents over 12 years old typically start at two sprays in each nostril once a day, which equates to 200 micrograms per day. However, some may find that one spray (50 mcg) per nostril daily is sufficient. Children between the ages of 2-11 should start with one spray in each nostril per day. The dosage can be increased after a few weeks if there's no response, but the maximum dose that should not be exceeded is two sprays (100 mcg) in each nostril daily for children and four sprays (200 mcg) for adults and adolescents over 12 years old.
At what dose is Qnasl typically prescribed?
Qnasl treatment typically begins with two sprays in each nostril once daily for adults and children 12 years of age and older, which equates to a dosage of approximately 320 mcg/day. If symptoms do not improve adequately, the dose can be increased to two sprays in each nostril twice daily (640 mcg). In children between the ages of 4 to 11 years old, the usual starting dose is one spray in each nostril once daily (80mcg). It's crucial to note that exceeding the recommended dosage could lead to adverse effects, so if there's no sufficient response after several weeks at this maximum dosage, consult your healthcare provider about other treatment options.
What are the most common side effects for Nasonex?
Common side effects for Nasonex and Qnasl include:
- Headache
- Viral infection (such as the common cold or flu)
- Coughing
- Nosebleeds
- Sore throat (pharyngitis)
- Sinus inflammation (sinusitis)
- Nasal irritation or burning
- Unpleasant taste in your mouth
- Nausea
However, most people do not experience all of these side effects, and some may not experience any. Always consult with a healthcare provider to ensure you understand potential risks before starting any new medication.
Are there any potential serious side effects for Nasonex?
While both Nasonex and Qnasl are generally safe to use, they may cause serious side effects in rare instances. These include:
- Severe allergic reactions: hives, difficulty breathing, swelling of your face or throat
- Vision problems: blurred vision, eye pain or redness, seeing halos around lights
- Signs of a hormonal disorder: unusual tiredness or weakness, feeling light-headed or fainting
- Nasal issues: severe nosebleeds; sores in the nose that won't heal; wheezing, trouble breathing; vision problems; fever, chills, body aches.
If you exhibit any signs of an infection such as persistent sore throat/fever/cough/night sweats/weight loss/listlessness - these might indicate that the medication has reduced your ability to fight infections.
In addition to this list of potential side effects for both medications individually – if you're using them together it's especially important to monitor your condition closely and report any changes immediately. If you experience any of these symptoms while taking either Nasonex or Qnasl (or especially while taking them simultaneously), seek immediate medical attention.
What are the most common side effects for Qnasl?
While taking Qnasl, you may experience the following side effects:
- Irritation or dryness in the nose
- Stuffy nose and sore throat
- Headache
- Nosebleeds
- A change in taste sensation
- Coughing, an increase in asthma symptoms
- Sneezing spells
Remember that these are potential side effects, not everyone will necessarily experience them. Also note that Qnasl is a corticosteroid nasal spray which can help reduce inflammation and treat symptoms of allergies such as sneezing, itching or runny nose. It's always best to consult with your healthcare provider if any of these adverse effects persist or worsen over time.
Are there any potential serious side effects for Qnasl?
While Qnasl is generally safe, it can sometimes cause severe side effects. These may include:
- Signs of an allergic reaction, such as hives; difficulty breathing; swelling of your face, lips, tongue or throat
- Flu-like symptoms (fever, chills)
- Nosebleeds or redness in the nose
- Sores or white patches inside or around your nose
- Blurred vision, eye pain
- Irregular heartbeats
- Changes in behavior and mood swings
If you observe any of these symptoms after using Qnasl, please discontinue its use and consult with a healthcare professional immediately. Remember that this list does not cover all possible side effects and others may occur.
Contraindications for Nasonex and Qnasl?
Like all nasal corticosteroids, both Nasonex and Qnasl may cause adverse reactions in some individuals. If you notice any severe side effects such as nosebleeds, changes in vision, shortness of breath or increased difficulty breathing, please seek immediate medical attention.
Neither Nasonex nor Qnasl should be used if you have an untreated active infection that affects your nose or throat. Always inform your physician about your current health status; infections need to be fully treated before starting with these medications to prevent exacerbation of the condition.
Moreover, it's vital not to abruptly stop using these medicines without consulting with a healthcare provider first. You might need to gradually reduce the dosage under professional supervision. It's also important not to share these inhalers with others since they are designed for individual patients' needs and sharing may spread infections.
How much do Nasonex and Qnasl cost?
For the brand name versions of these drugs:
- The price of a 17 g bottle of Nasonex, which contains about 120 sprays, averages around $240. This works out to roughly $8/day (assuming one spray per nostril each day).
- The cost of Qnasl is similar. A canister with approximately 120 doses costs about $200–$250, working out to be approximately $7–$9/day.
Thus, if you are using a typical dosage for either nasal spray (i.e., one or two sprays in each nostril daily), then both brand-name Nasonex and Qnasl have comparable costs on a per-day treatment basis. Please note that cost should not be a primary consideration in determining which drug is right for you.
As far as generic versions go:
- Mometasone furoate (the active ingredient in Nasonex) is available at lower prices than its branded counterpart; however, it's important to note that there may still be significant variation in cost depending on the pharmacy.
- Beclomethasone dipropionate (the active ingredient in Qnasl) also has cheaper generic alternatives available.
Keep in mind that actual costs can vary based on your insurance coverage and the pharmacy where you purchase your medication.
Popularity of Nasonex and Qnasl
Mometasone in brand versions such as Nasonex, was estimated to have been prescribed to about 2.1 million people in the US in 2020. Mometasone accounted for just over 6% of corticosteroid nasal spray prescriptions in the US. However, it appears to be a common choice among "intranasal" corticosteroids (used directly within the nose). The usage of mometasone has been generally increasing since its approval by FDA.
Beclomethasone dipropionate, including brand versions such as Qnasl, was prescribed to approximately 800 thousand people in the USA in 2020. In terms of intranasal corticosteroid prescriptions, beclomethasone accounts for around 5%. Its prevalence has remained relatively steady over recent years suggesting consistent trust and reliability from healthcare providers and patients alike.
Conclusion
Both Nasonex (mometasone furoate) and Qnasl (beclomethasone dipropionate) are corticosteroid nasal sprays that have established records of use in treating nasal allergy symptoms, backed by several clinical studies demonstrating their effectiveness over placebo. They work by reducing inflammation in the nasal passages. Sometimes both drugs may be used together under a doctor's supervision, even though they should not be used concurrently without medical advice due to possible cumulative steroid exposure.
Nasonex is often considered as a first-line therapy for seasonal and perennial allergic rhinitis due to its proven efficacy and safety profile, while Qnasl might typically be introduced if patients do not respond well to initial treatment or require additional symptom control.
Generic versions are available for both Nasonex and Qnasl which can lead to significant cost savings, especially for those paying out of pocket. Both medications may require some time before their full effects become apparent.
The side effect profiles of these two medications are similar with potential side effects like nosebleed, headache, sore throat being common but generally mild. However, it’s essential that users monitor for any signs of worsening conditions or unusual symptoms such as vision problems or persistent nosebleeds - if noticed these should prompt immediate consultation with a healthcare provider.
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Refrences
- Baldwin, C. M., & Scott, L. J. (2008). Mometasone Furoate. Drugs. Springer Science and Business Media LLC.http://doi.org/10.2165/00003495-200868120-00009
- Schenkel, E. (2003, September). Features of mometasone furoate nasal spray and its utility in the management of allergic rhinitis. Expert Opinion on Pharmacotherapy. Informa Healthcare.http://doi.org/10.1517/14656566.4.9.1579
- Gawchik, S., Goldstein, S., Prenner, B., & John, A. (2003, April). Relief of cough and nasal symptoms associated with allergic rhinitis by mometasone furoate nasal spray. Annals of Allergy, Asthma & Immunology. Elsevier BV.http://doi.org/10.1016/s1081-1206(10)61826-1
- Bronsky, E. A., Aaronson, D. W., Berkowitz, R. B., Chervinsky, P., Graft, D., Kaiser, H. B., … Nolop, K. B. (1997, July). Dose Ranging Study of Mometasone Furoate (Nasonex) in Seasonal Allergic Rhinitis. Annals of Allergy, Asthma & Immunology. Elsevier BV.http://doi.org/10.1016/s1081-1206(10)63084-0