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What is Kurvelo
LevonorgestrelThe Generic name of this drug
Treatment SummaryLevonorgestrel (LNG) is a progestin hormone used for contraception, hormonal therapy, and emergency contraception. It’s most commonly known as Plan B and is available as a single agent or an intrauterine device (IUD). It can also be found in long-term combination contraceptives and as a subdermal implant that slowly releases the hormone over a long-term period. Levonorgestrel is the most widely used type of emergency contraceptive and was approved by the FDA in 1982. It is highly effective, with less estrogenic side effects than older emergency contraceptive regimens.
Triphasil-21is the brand name
Kurvelo Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Triphasil-21
Levonorgestrel
1984
243
Approved as Treatment by the FDA
Levonorgestrel, also known as Triphasil-21, is approved by the FDA for 6 uses including Hot flashes and Osteoporosis, Postmenopausal .Hot flashes
Used to treat Menopause in combination with Estradiol
Osteoporosis, Postmenopausal
Used to treat Postmenopausal Osteoporosis in combination with Estradiol
Menopause
Used to treat severe Vasomotor Symptoms Associated With Menopause in combination with Estradiol
moderate Menopausal Vasomotor Symptoms
Used to treat moderate Menopausal Vasomotor Symptoms in combination with Estradiol
Has had at least 1 child
Emergency Contraception
Effectiveness
How Kurvelo Affects PatientsLevonorgestrel is a contraceptive used to prevent pregnancy. When taken as a pill within 72 hours of having unprotected sex, it is 89% effective. Devices containing levonorgestrel, such as intrauterine and implantable devices, are more than 99% effective in preventing pregnancy. It can also be used as part of hormone therapy to prevent endometrial cancer caused by taking estrogen alone.
How Kurvelo works in the bodyLevonorgestrel is a hormone commonly used in oral contraceptives. It works by blocking the release of hormones that cause ovulation and thickening cervical mucus to stop sperm from entering the uterus. It can also be used to decrease the risk of endometrial cancer when combined with estrogen therapy. The exact mechanism of action of levonorgestrel is not completely understood.
When to interrupt dosage
The advised dosage of Kurvelo is contingent upon the determined condition, including Endometrial Hyperplasia, Emergency Contraception and Hypermenorrhea. The measure of dosage fluctuates, per the technique of delivery specified in the table beneath.Condition
Dosage
Administration
Has had at least 1 child
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Menopause
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Endometriosis
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Endometrial Hyperplasia
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Hot flashes
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Emergency Contraception
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Osteoporosis, Postmenopausal
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Menorrhagia
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
moderate Menopausal Vasomotor Symptoms
, 0.75 mg, 1.5 mg, 52.0 mg, 1.39 mg, 0.15 mg, 0.1 mg, 36.0 mg, 0.25 mg, 0.125 mg, 0.075 mg, 13.5 mg, 0.09 mg, 1.5 mg/mg, 19.5 mg, 0.0015 mg/hour, 0.03 mg, 0.05 mg, 0.45 mg, 2.6 mg, 0.3 mg
Oral, Kit - Oral, , Kit, Tablet, Tablet - Oral, Intrauterine, Intrauterine device, Intrauterine device - Intrauterine, Transdermal, Patch - Transdermal, Patch, Insert, extended release, Insert, extended release - Intrauterine, Subcutaneous, Implant, Implant - Subcutaneous, Tablet, film coated, Tablet, film coated - Oral
Warnings
Kurvelo has forty-three contraindications, so it should not be taken in conjunction with any of the conditions detailed in the following table.Kurvelo ContraindicationsCondition
Risk Level
Notes
Septic Abortion
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Abortion, Spontaneous
Do Not Combine
HCG elevated
Do Not Combine
Pelvic Infection
Do Not Combine
Vaginitis
Do Not Combine
Acute Coryza
Do Not Combine
Breast Neoplasms
Do Not Combine
Uterine Cervicitis
Do Not Combine
Communicable Diseases
Do Not Combine
Gonorrhea
Do Not Combine
Breast Cancer
Do Not Combine
Intrauterine Devices
Do Not Combine
Liver Neoplasms
Do Not Combine
congenital or aquired uterine abnormality
Do Not Combine
Chlamydia Infections
Do Not Combine
Hypersensitivity
Do Not Combine
Emergency Contraception
Do Not Combine
Endocarditis, Bacterial
Do Not Combine
Vaginosis, Bacterial
Do Not Combine
suspected pregnancy
Do Not Combine
Uterine Cervicitis
Do Not Combine
uterine neoplasia
Do Not Combine
Pelvic Inflammatory Disease
Do Not Combine
Breast Neoplasms
Do Not Combine
Uterine Cervical Neoplasms
Do Not Combine
Fibroid Tumor
Do Not Combine
Endometritis
Do Not Combine
chlamydial cervical infection
Do Not Combine
PAP Test Abnormalities
Do Not Combine
Liver Failure, Acute
Do Not Combine
Uterine anomaly distorting uterine cavity
Do Not Combine
Breast Cancer
Do Not Combine
Cervical Dysplasia
Do Not Combine
Thromboembolism
Do Not Combine
Bacterial Vaginosis
Do Not Combine
history of pelvic inflammatory disease
Do Not Combine
Breast
Do Not Combine
Vaginal Bleeding
Do Not Combine
Bacterial Vaginosis
Do Not Combine
Pelvic Inflammatory Disease
Do Not Combine
Gonorrhea
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Levonorgestrel may interact with Pulse Frequency
Common Kurvelo Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Levonorgestrel.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Levonorgestrel.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Levonorgestrel.
Copanlisib
Major
The metabolism of Copanlisib can be decreased when combined with Levonorgestrel.
Crizotinib
Major
The metabolism of Crizotinib can be decreased when combined with Levonorgestrel.
Kurvelo Toxicity & Overdose RiskThe lowest toxic dose of levonorgestrel in rats is greater than 5000mg/kg. Overdosing on this drug can cause nausea and bleeding. Treatment for overdose includes symptomatic care and contacting a local poison control center. There is no specific antidote for a levonorgestrel overdose.
Kurvelo Novel Uses: Which Conditions Have a Clinical Trial Featuring Kurvelo?
99 active clinical trials are currently being conducted to assess the utility of Kurvelo in treating Postmenopausal Osteoporosis, Women who have had at least 1 child and Endometrial Hyperplasia.Condition
Clinical Trials
Trial Phases
Hot flashes
14 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4
Endometriosis
32 Actively Recruiting
Early Phase 1, Phase 2, Phase 3, Not Applicable, Phase 4, Phase 1
Has had at least 1 child
0 Actively Recruiting
Menorrhagia
0 Actively Recruiting
Endometrial Hyperplasia
3 Actively Recruiting
Not Applicable, Phase 2
moderate Menopausal Vasomotor Symptoms
0 Actively Recruiting
Menopause
0 Actively Recruiting
Osteoporosis, Postmenopausal
0 Actively Recruiting
Emergency Contraception
1 Actively Recruiting
Phase 4
Kurvelo Reviews: What are patients saying about Kurvelo?
5Patient Review
8/1/2016 I started seeing results within the first week, but unfortunately one of those results was water retention and weight gain. I stuck it out for nine weeks in the hopes that things would get better, but they didn't so I'm trying a different treatment tomorrow. Additionally, I had really bad PMS while on this medication; more specifically, extreme sadness and irritability. Overall, not a great experience for me.
5Patient Review
10/29/2021 I've been using Kurvelo for a while now, and it's the only birth control that doesn't make me break out. I was upset when my pharmacy told me they couldn't get it anymore, but luckily I was able to find another one that does.
5Patient Review
7/8/2020 I've had almost no negative side effects from this medication, and it's been working great for me. I've been taking it regularly for three years now.
4.7Patient Review
1/15/2017 I'm wondering if this birth control will make my period come every three months or every month?
4.7Patient Review
9/10/20154.3Patient Review
6/11/2017 I've been using this pill for almost three years now. It's lightened my period flow and cramps a lot, which is great. I have recently started spotting between cycles, though, which wasn't happening before. Has anyone else experienced this?
4Patient Review
3/1/2017 This medication has lightened my menstrual flow and reduced the number of blood clots I experience. It's also been great in preventing pregnancy with few side effects. Overall, I'm very pleased with it.
4Patient Review
11/27/2017 I started Kurvelo recently to help with my PCOS, and it's been working great so far! I used to go up to two months without a period, and now they're much more regular. The only downside is that I've been having really bad cramps (which I never had before) and a very heavy flow.
3.7Patient Review
1/28/2021 I would not recommend this birth control to anyone. It has caused me a great deal of emotional distress and I have gained weight since starting it.
3.7Patient Review
6/7/2016 I was given this at the pharmacy as a generic form of Altavera, but I have been experiencing spotting and heavy bleeding since taking it. There is a vast difference between this and the brand name; I'm going to switch back when I am able to refill my prescription.
2.3Patient Review
10/14/2016 I've been on this medication for six months. At first, the hormonal changes made me a little emotional, but that only lasted for a month or two. After that, it's been great-- effective and my periods are super light and painless.
2Patient Review
5/24/2021 I cannot recommend this birth control because it has been absolutely terrible for me. I've experienced nausea, heartburn, throwing up, crying, and mood swings. It's been a nightmare.
1Patient Review
5/17/2020 I had a migraine and this treatment did not help at all.
Patient Q&A Section about kurvelo
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Kurvelo birth control good?
"There is no 100% effective method of birth control currently, but oral contraceptives like Kurvelo® have been shown to be highly effective. In studies, it has been shown that for every 100 women taking birth control, less than 1 will become pregnant when taking the medication as prescribed."
Answered by AI
What are the side effects of Kurvelo?
"The following side effects may occur: nausea, vomiting, headache, bloating, breast tenderness, swelling of ankles/feet (fluid retention), or weight change. Spotting (vaginal bleeding between periods) or missed/irregular periods may occur, especially during the first few months of use."
Answered by AI
What kind of birth control pill is Kurvelo?
"Kurvelo is a pill used for contraception to prevent pregnancy. It belongs to a class of drugs called Estrogens/Progestins, which are oral contraceptives. It can be used alone or with other medications."
Answered by AI