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What is Monoket
Isosorbide mononitrateThe Generic name of this drug
Treatment SummaryIsosorbide mononitrate is a medication used to treat chest pain from coronary artery disease. It is an organic nitrate that relaxes the smooth muscles in arteries and veins, which helps reduce the workload of the heart. Isosorbide mononitrate is available in oral tablets and extended-release forms under the brand names ISMO and Monoket. It was approved by the FDA in 1991 and is generally well-tolerated.
Monoketis the brand name
Monoket Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Monoket
Isosorbide mononitrate
1993
188
Effectiveness
How Monoket Affects PatientsIsosorbide mononitrate is a medication used to prevent and manage angina. It relaxes the blood vessels, allowing more oxygen and blood to reach the heart. This reduces the work the heart has to do and prevents chest pain. Isosorbide mononitrate also relaxes other types of smooth muscles, such as those in the esophagus and bile ducts. Taking it usually provides relief from chest pain within an hour, and the effects can last up to 12 hours.
How Monoket works in the bodyIsosorbide mononitrate works by releasing nitric oxide, which is a gas that helps blood vessels relax and widen. This process is triggered by an increase of cyclic GMP, which activates protein kinases. These protein kinases then reduce the amount of calcium in the cells, which leads to the relaxation of smooth muscle cells and blood vessels widening.
When to interrupt dosage
The proposed dose of Monoket is contingent upon the indicated condition. The measure of dosage is contingent upon the technique of administration (e.g. Tablet or Tablet, extended release) as specified in the table below.Condition
Dosage
Administration
Coronary Disease
120.0 mg, , 30.0 mg, 60.0 mg, 20.0 mg, 10.0 mg
, Tablet, extended release, Oral, Tablet, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral
Chest Pain
120.0 mg, , 30.0 mg, 60.0 mg, 20.0 mg, 10.0 mg
, Tablet, extended release, Oral, Tablet, extended release - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
Monoket has three contra-indications, so it should not be taken while enduring any of the circumstances outlined in the table below.Monoket ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Isosorbide Mononitrate may interact with Pulse Frequency
Common Monoket Drug Interactions
Drug Name
Risk Level
Description
Riociguat
Major
Isosorbide mononitrate may increase the hypotensive activities of Riociguat.
Sildenafil
Major
The risk or severity of hypotension can be increased when Isosorbide mononitrate is combined with Sildenafil.
Abacavir
Minor
Isosorbide mononitrate may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acebutolol
Minor
The risk or severity of adverse effects can be increased when Isosorbide mononitrate is combined with Acebutolol.
Aclidinium
Minor
Isosorbide mononitrate may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Monoket Toxicity & Overdose RiskThe lowest toxic dose of isosorbide mononitrate in rats is 2010mg/kg and 1771mg/kg in mice. Overdosing on isosorbide mononitrate can cause vasodilation, low blood pressure, increased intracranial pressure, vertigo, palpitations, visual disturbances, nausea, vomiting, syncope, air hunger, sweating, heart blocks and bradycardia, paralysis, coma, seizures, and death. To manage an overdose, it is recommended to elevate the patient's legs and give them intravenous fluids like normal saline. Dialysis may also be used to
Monoket Novel Uses: Which Conditions Have a Clinical Trial Featuring Monoket?
11 active trials are presently assessing the effectiveness of Monoket in relieving Chest Pain.Condition
Clinical Trials
Trial Phases
Coronary Disease
1 Actively Recruiting
Not Applicable
Chest Pain
2 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Patient Q&A Section about monoket
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is isosorbide used for?
"Isosorbide is used to manage chest pain in people with coronary artery disease."
Answered by AI
Is it OK to take isosorbide at night?
"This medicine works best if you space out your doses throughout the day, with a "drug-free" period of time in between each dose. Your doctor will schedule your doses to make sure there is enough time in between each dose for the medicine to work properly."
Answered by AI
What is monoket used for?
"This medication is used to prevent chest pain in patients with coronary artery disease. It belongs to a class of drugs known as nitrates. It works by relaxing and widening blood vessels so blood can flow more easily to the heart."
Answered by AI
What are the side effects of isosorbide mononitrate?
"The following are symptoms of a heart attack: an abnormal heart sound, a decrease or absence of body movement, pain in the arm, back, or jaw, black or tarry stools, bladder pain, bleeding after defecation, blood in the urine or stools, and body aches or pain."
Answered by AI