Zoloft and Viibryd are selective serotonin reuptake inhibitors (SSRIs) used to treat depression. SSRIs work by increasing serotonin levels in the brain. Serotonin handles carrying signals between neurons and brain nerves. This neurotransmitter controls your mood. It also helps regulate other aspects of your daily living, such as: 

SSRIs are the most prescribed antidepressants due to their safety. They also cause fewer side effects. No matter how popular they are, you must use them with caution. This is especially true if you have underlying health issues such as: 

Healthcare professionals usually prescribe 

 for depression. It is an SSRI that works by restoring the balance of natural substances in the brain. One of them is the neurotransmitter serotonin. 

It helps improve sleep, mood, appetite, and energy levels. Viibryd is also a partial agonist of the serotonin 1A receptor. It is usually prescribed with the aim of restoring a person's interest in daily living. 

What Conditions Is Viibryd Approved to Treat?

The US Food and Drug Administration (FDA) approved it for major depressive disorder. The FDA approved it on January 21, 

It is also used for treating generalized anxiety disorder in adults. You should take it according to a healthcare professional's instructions. 

How Does Viibryd Work for Mental Disorders?

MDD is usually a result of a chemical imbalance in the brain. It is in the form of a lack of serotonin, a neurotransmitter responsible for regulating mood. Viibryd works by increasing the levels of serotonin in the brain. As a result, there is an improvement in the symptoms of depression. 

As an SSRI, Viibryd blocks the reuptake of serotonin in the brain. It allows more of the neurotransmitter to be available for use. Additionally, it also acts as a partial agonist of the serotonin 1A receptor. Hence, it also helps to further increase the availability of serotonin in the brain.

These two mechanisms of action make Viibryd effective in treating depression. By increasing the amount of serotonin in the brain, it can help to:

 is a brand name for the antidepressant medication 

. It belongs to a class of medications called selective serotonin reuptake inhibitors (SSRIs). It increases the levels of serotonin in the brain. Zoloft is usually taken in tablet or liquid form and is available by prescription only. 

It is important to follow the dosage instructions provided by your healthcare provider. Make sure to speak with them about any potential side effects or concerns you may have.

What Conditions Is Zoloft Approved to Treat?

The FDA first approved the drug for treating depression in 1991. 

It can treat the following disorders/conditions:

How Does Zoloft Work for Mental Disorders?

Zoloft works by increasing the levels of serotonin in the brain. This neurotransmitter regulates mood, emotions, and behavior.

In most mental disorders, there is a serotonin imbalance in the brain. Zoloft helps to restore this balance by inhibiting the reuptake of serotonin. This way, more of this neurotransmitter remains in the brain.

By increasing the levels of serotonin, Zoloft can help to ease the symptoms of:

These conditions can cause feelings of worry, sadness, and panic. Zoloft aims to reduce these symptoms. It also aims to improve sleep, appetite, and energy levels.

But, it is important to note that Zoloft may not work for everyone. In some cases, it may even take several weeks for the medication to have an effect. Hence, it’s important to seek guidance from a healthcare provider. They will help determine the appropriate dosage and also check for potential side effects.

How Effective Are Viibryd and Zoloft for Mental Disorders?

Healthcare professionals prescribe both drugs for mental disorders, particularly depression, and anxiety. Both work by increasing the serotonin levels in the brain. But, the efficacy of these medications may vary depending on the individual. It may also depend on the severity of their condition.

, both drugs were effective. This randomized trial compared vilazodone and sertraline for treating depression. 

While both were effective for depressive symptoms, vilazodone had advantages over the latter. Vilazodone (Viibryd) worked well in terms of weight gain and adverse sexual effects.

 tested the effectiveness of sertraline in primary care patients with depression. Their symptoms ranged from mild to severe. It concluded that sertraline couldn't reduce depressive symptoms in the first six weeks. Researchers observed general improvements in self-rated mental health, quality of life, and anxiety. 

In two 8-week placebo-controlled trials, vilazodone was more effective than the placebo. It improved depressive symptoms, but some adverse reactions were also observed, such as: 

But, more studies should assess the safety and efficacy of viladozone beyond 8 weeks. 

Viibryd is usually administered orally. It is available in the following strengths:

The dosage of Viibryd can vary depending on the individual's age, the severity of their problem, and other factors.

How Is Zoloft Administered for Mental Disorders?

Zoloft is available in different forms, including; 

Zoloft is only recommended with a doctor's prescription. The dosage of Zoloft can vary depending on the individual's age, the severity of their problem, and other factors.

Both Viibryd and Zoloft carry their own side effects. If you experience the below-mentioned side effects, speak to your doctor immediately. You can also stop your medicine based on their advice.

What Are the Most Common Side Effects of Zoloft?

The most common side effects of Zoloft include the following; 

Are There Any Potentially Serious Side Effects of Zoloft?

Some of the serious side effects of Zoloft include the following; 

What Are the Most Common Side Effects of Viibryd?

The most common side effects of Viibryd include the following; 

Are There Any Potentially Serious Side Effects of Viibryd?

Some of the serious side effects of Viibryd include the following;

Warnings and General Precautions for Viibryd and Zoloft 

If you have recently stopped taking an MAO inhibitor, you must wait 14 days before taking Viibryd. But, you may have to speak to your healthcare professional for certainty.

Sudden withdrawal of either of the two medicines can lead to adverse outcomes. If you suddenly stop Viibryd or Zoloft, you may experience the following symptoms:

In most cases, discontinuation symptoms last for about one to three weeks. But, some people may also experience them for months.

Observing caution and general precautions is always important. It's vital to ensure that there are no dangerous interactions between medications. Additionally, discontinuing any medication without consulting a healthcare professional can also cause problems. 

Contraindications and Important Interactions for Zoloft and Viibryd

Do not use Viibryd if you’re taking a monoamine oxidase inhibitor (MAOI).

Do not use it if you are allergic to its main component, sertraline, or if you also take pimozide.

Limit your intake of grapefruit or grapefruit juice.

Avoid drinking alcohol with Viibryd. While there is no direct link between the two, you may experience heightened side effects. These could include impaired judgment, dizziness, and drowsiness.

Do not take fruits like grapefruit as its enzyme can hinder metabolism. 

Avoid drinking alcohol. Also, avoid consuming too much caffeine, as it may worsen your symptoms.

Prices for both drugs may vary due to many factors, such as insurance, dosage, and quantity. They can even depend on the location and pharmacy you buy from.

The price of Zoloft may be more than $500 if you’re paying out of pocket. The cost can vary depending on whether you opt for a brand or a generic version. It may also depend on the number of pills in one prescription. 

The price for Viibryd oral kit is about $358 for around 30 kits. But it depends on the pharmacy you visit. The cost depends on the prescribed dosage and insurance plans. Both medications are often covered by insurance.

Both are popular medications for major depressive disorder and generalized anxiety disorder. 

They both hold high rankings among the millions of products available in the markets. Furthermore, Zoloft even ranked number 12 on the 2020 ratings list.

It is by far the most prescribed antidepressant. It had more than 38 million prescriptions in 2017. The popularity of this drug reflects its safety, efficacy, and tolerability. 

SSRIs are more popular than any other class of drugs due to various factors. For one, they don’t have as many side effects. They also have better clinical efficacy. Most importantly, they’re not limited to treating depression. 

They can also treat various other mental disorders, unlike other classes of drugs. Some are often limited to treating a particular condition. Generally, SSRIs have played a crucial role in revolutionizing therapy for depression. 

Viibryd vs Zoloft

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