Serzone

Depression
Treatment
1 FDA approval
20 Active Studies for Serzone

What is Serzone

NefazodoneThe Generic name of this drug
Treatment SummaryNefazodone hydrochloride (brand name Serzone) was an antidepressant drug made by Bristol-Myers Squibb. In 2003, it was discontinued in some countries due to a very small risk of liver damage. In rare cases, it was linked to a need for a liver transplant or death. On May 20, 2004, Bristol-Myers Squibb stopped selling Serzone in the United States.
Serzoneis the brand name
image of different drug pills on a surface
Serzone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Serzone
Nefazodone
1994
33

Approved as Treatment by the FDA

Nefazodone, otherwise known as Serzone, is approved by the FDA for 1 uses like Depression .
Depression

Effectiveness

How Serzone Affects PatientsNefazodone is a medication used to treat major depression. It is similar to the antidepressant trazodone, but works differently, and has fewer risks of serious cardiovascular problems or insomnia than other antidepressants.
How Serzone works in the bodyNefazodone works on two different systems in the body. First, it increases the amount of serotonin available to interact with serotonin receptors. Second, it blocks the effects of norepinephrine, a chemical that helps to regulate the body's response to stress. Nefazodone also has less significant effects on other receptors, like benzodiazepine and cholinergic receptors.

When to interrupt dosage

The proposed measure of Serzone is contingent upon the diagnosed condition. The quantity of dosage additionally depends on the approach of delivery (e.g. Tablet or Tablet - Oral) documented in the table below.
Condition
Dosage
Administration
Depression
, 100.0 mg, 200.0 mg, 250.0 mg, 150.0 mg, 50.0 mg
, Oral, Tablet, Tablet - Oral

Warnings

Serzone Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Liver
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Serzone.
Common Serzone Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Nefazodone.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Nefazodone.
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Nefazodone.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Nefazodone.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Nefazodone.
Serzone Toxicity & Overdose RiskIn some cases, taking nefazodone can result in a dangerous form of liver failure.
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Serzone Novel Uses: Which Conditions Have a Clinical Trial Featuring Serzone?

Currently, 601 active clinical trials are underway to explore the possible utilization of Serzone in addressing Depression.
Condition
Clinical Trials
Trial Phases
Depression
305 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4, Phase 3

Serzone Reviews: What are patients saying about Serzone?

5Patient Review
1/23/2013
Serzone for Major Depressive Disorder
Since returning from Vietnam in 1971 and diagnosed at that time with PTSD I was subjected to 11 years of trial and error with all drugs. Nefazadone has been the best for me and highly reccomended. Man what a difference I see when NOT taking it for a couple of days.
5Patient Review
9/28/2013
Serzone for Depression
I was diagnosed with PTSD, panic disorder, insomnia and depression six months ago. I started taking ATIVAN but didn't like the effects, so my doctor put me on colozapam. It works OK but I still have angry outbursts, so now I am trying nefazadone. So far it seems to be working.
5Patient Review
1/1/2015
Serzone for Depression
Nefazadone/sera zone has been a life-changing medication for me. After trying 7 different antidepressants that didn't work, I was finally prescribed this drug about 17 years ago. It's helped me immensely and I'm now looking to start my doctoral degree. I would love to do research related to this drug and its efficacy in treating depression and ADHD.
5Patient Review
1/15/2022
Serzone for Depression
Nefazodone's recent availability has been a godsend. It has really helped with my depression and anxiety, to the point where I've been taking it for over 20 years without any side effects. Honestly, none of the other medications I tried did anything remotely as effective as this one when it comes to reducing my anxiety.
5Patient Review
5/12/2012
Serzone for Depression
I've been taking this medication for over 20 years, but recently I haven't been able to get it because of backorders from the manufacturer. Do you know what's causing the issue and if there's a comparable substitute?
5Patient Review
3/12/2022
Serzone for Panic Disorder
I'm so glad that Nefazodone is available again. This medication has been a life-changer for me, helping with my anxiety in a way that nothing else has ever done before. If you're struggling with this issue, I recommend checking out the Facebook Support group "Nefazodone Shortage Survivors and Support."
5Patient Review
4/28/2010
Serzone for Depression
5Patient Review
10/18/2010
Serzone for Depression
I've been taking this for 10 years and it's really helped me. I tried other antidepressants before this one, but the side effects were too much to handle. With this medication, my liver tests have come back fine and there's no nausea if I take it with food. It's allowed me to live a normal life again and I'm very grateful for that.
5Patient Review
9/13/2013
Serzone for Depression
I was unable to get assistance with getting the medications. Can't afford it. No income, unemployed for over 2 years.
5Patient Review
4/28/2010
Serzone for Depression
5Patient Review
10/18/2010
Serzone for Depression
I've been taking this medication for a decade and it has really improved my quality of life. I've tried other antidepressants that come with nasty side effects, but this one is much more tolerable. So long as I take it with food, I don't experience any nausea either.
5Patient Review
1/23/2013
Serzone for Major Depressive Disorder
Since I was diagnosed with PTSD after returning from Vietnam in 1971, I've tried a lot of different medications. Nefazadone has been the best for me by far, and I highly recommend it to others. It's made such a difference in my life that it's hard to go even a couple days without it.
5Patient Review
5/12/2012
Serzone for Depression
I've been taking this medication for over 20 years, but recently I haven't been able to get it because of manufacturer backorders. Do you know what the problem is and if there's a comparable substitute?
5Patient Review
9/28/2013
Serzone for Depression
I've been dealing with some serious mental health issues for the past six months, including PTSD, severe panic disorder, insomnia and depression. I was originally prescribed Ativan, but didn't like the way it made me feel. So then my doctor put me on colozapam, which helped a little bit but I still had angry outbursts. Today is my first day taking nefazadone and so far it seems to be working well.
5Patient Review
1/1/2015
Serzone for Depression
After trying 7 antidepressants that didn't work 20 years ago, I'm hyperactive also, I finally was prescribed nefazadone/sera zone about 17 years ago. It's been a blessing. I finished my master's degree 5 years ago and looking to start my doctoral.
5Patient Review
9/13/2013
Serzone for Depression
I was unable to get assistance with getting the medications. I couldn't afford it and have been unemployed for over 2 years.
5Patient Review
1/15/2022
Serzone for Depression
Nefazodone has been re-stocked and I am so grateful. This medication has done worlds of good for my depression and anxiety-- better than any other antidepressant I've tried in the 20 years I've been taking it.
5Patient Review
3/12/2022
Serzone for Panic Disorder
I'm so glad that Nefazodone is available again. I've been taking it for over 20 years and it's the only thing that helps with my anxiety. There's a great Facebook support group called "Nefazodone Shortage Survivors and Support" where you can find more information about this medication.
4.7Patient Review
5/31/2012
Serzone for Depression
I've been taking this medication for 10 years and it's worked great for me, but now my pharmacy is having trouble filling my prescription. I'm not sure what's going on, but I hope they can continue to provide this product.
4.7Patient Review
9/29/2013
Serzone for Depression
I've been on this medication for a prolonged period of time and it has drastically improved my quality of life. That being said, sometimes it can be difficult to find my 200 mg dose in stores.
4.7Patient Review
8/10/2019
Serzone for Major Depressive Disorder
I miss this medication dearly; it was the only one that effectively treated my depression and anxiety. The side effects, while not ideal, were manageable for me. I think it's really important that this drug be available again in Australia.
4.7Patient Review
8/10/2019
Serzone for Major Depressive Disorder
I took this medication for several years before it was withdrawn from the market in Australia. It was the only medication that treated my depression & anxiety. Side effects for me were heavy sedation (especially in mornings), restless legs, nausea, weight loss. But overall, I think the side effects were worth it. My liver function was monitored via blood tests and it was fine. Bring this back to the market in Australia; it is vital! There is no equivalent!
4.7Patient Review
5/31/2012
Serzone for Depression
I've been taking this medication for 10 years and have had great results. However, my pharmacist is now having difficulty filling my prescription. I would like to know why this is happening and if there are any alternatives available.
4.7Patient Review
9/29/2013
Serzone for Depression
I've been on this medication for a long time and it has really changed my life for the better. That said, I have run into issues in the past where my pharmacist wasn't able to fill my script for the 200mg dose that I need.
3Patient Review
6/6/2022
Serzone for Depression
I just started this medication and I'm already feeling drowsy. I only took 100mg, is this normal? Will the effects wear off over time?
3Patient Review
6/6/2022
Serzone for Depression
I've just started taking this medication, and I'm already feeling very drowsy. I only took 100mg, is this normal? Will the side effects go away?
2.3Patient Review
11/4/2012
Serzone for Major Depressive Disorder
My blood pressure rose to an unhealthy level after only a couple weeks, and I experienced other issues like shaking and memory problems. I had to go the hospital, where they said everything was fine and charged me $6,000.
2.3Patient Review
11/4/2012
Serzone for Major Depressive Disorder
My blood pressure spiked alarmingly after only a couple weeks of taking this medication. I also started shaking and forgetting things. I had to go to the hospital, where they said there was no issue. Without insurance, this treatment cost me $6,000 out of pocket.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about serzone

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Why is nefazodone no longer used?

"The antidepressant nefazodone hydrochloride (Serzone) is being discontinued by the manufacturer due to concerns of hepatotoxicity. The last day of sale will be Nov. 27, 2003."

Answered by AI

What kind of drug is Serzone?

"SERZONE works by blocking the reuptake of serotonin, a neurotransmitter in the brain, by neurons. This action increases the level of serotonin in the brain and helps relieve depression.

SERZONE is an antidepressant that is taken orally. It works by blocking the reuptake of serotonin, a neurotransmitter, by neurons. This action increases the level of serotonin in the brain and helps relieve depression."

Answered by AI

Is Serzone still prescribed?

"The brand medication of Nefazodone, Serzone, was discontinued in 2003 in the United States due to the rare occurrence of severe liver damage."

Answered by AI

Is Serzone an SSRI or an SNRI?

"Nefazodone is not in the same class of drugs as the serotonin reuptake inhibitors (SSRIs), the tricyclic antidepressants (TCAs), or the monoamine oxidase (MAO) inhibitors. It is similar to another antidepressant, trazodone (Desyrel), in terms of how it works. The FDA approved nefazodone in December 1994."

Answered by AI

Clinical Trials for Serzone

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Behavioral Interventions for Depression in Students

Any Age
All Sexes
Cottage Grove, OR
The goal of this clinical trial is to learn if two behavioral interventions work to reduce office disciplinary referrals, improve attendance, and reduce depression and anxiety in 7th grade students. This project combines two evidence-based programs-the Inclusive Skill-building Learning Approach (ISLA) for school-wide discipline reform and the Family Check-Up Online (FCU-O) for family-centered support-in an adaptive design to examine the unique and additive effects of these interventions on these child behavior outcomes. The main questions it will answer are: 1. What is the relative efficacy of ISLA vs. School-as-Usual? 2. What is the optimal sequencing of these interventions? 3. Which overall sequence of intervention strategies was most effective? Researchers will compare 6 combinations of these interventions to see which combination and sequencing provides the best student outcomes. School personnel participating in the project will be trained to implement the two interventions at their school. They will answer surveys in the fall, winter, and spring of their year of participation. Parent and Youth participants will complete surveys at baseline and then again 6 months and 12 months later.
Waitlist Available
Has No Placebo
Lincoln Middle School (+12 Sites)Beth Stormshak, PhD
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Living Well Program for Anxiety in Breast Cancer

18+
Female
Los Angeles, CA
The goal of this study is to evaluate the efficacy and cost-effectiveness of the Living Well Program, a digital therapeutic application with telecoaching support, in breast cancer patients with moderate-to-severe anxiety. The main question the study aims to answer is: does digital cognitive-behavioral therapy-based interventions decrease the overall healthcare costs of patients with stage II to IV breast cancer? The study has one group of participants who will use the Living Well app and telecoaching support. This group will be compared to retroactively matched controls. Over 3 months, patients will complete 21 mental health modules and 5 telecoaching sessions. In the following 3 months, they will complete any outstanding telecoaching sessions and modules while still being monitored, even if they finished all modules and sessions in the first 3 months. The 6 months after that will be the follow-up phase. They will still have access to the Living Well app and may continue to use it, and they will complete the same assessment questionnaires as baseline to identify any changes in their overall mental health.
Waitlist Available
Has No Placebo
Cedars-Sinai Medical CenterScott Irwin, MD
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AI Chatbot for Postpartum Loneliness

18+
Female
La Jolla, CA
The goal of this clinical trial is to learn whether a postpartum chatbot powered by generative artificial intelligence (genAI) can help new mothers get better pelvic floor health information and feel less lonely after childbirth. The main questions this study aims to answer are: * Does using the chatbot improve postpartum pelvic floor health knowledge? * Does using the chatbot help reduce feelings of loneliness during the postpartum period? * Does using the chatbot impact pelvic floor symptoms? Researchers will compare standard postpartum care to standard care plus the chatbot. Participants will: Be assigned by chance (like flipping a coin) to standard postpartum care with or without access to the chatbot. If in the chatbot group, participants will receive education and support via the chatbot over a 4-week period. Both groups will complete questionnaires to measure their pelvic floor knowledge, pelvic floor symptoms, feelings of loneliness, depression, infant bonding, perceived social support, adverse childhood experiences, and peri-traumatic distress. The chatbot was created by urogynecology experts in collaboration with UC San Diego computer science and biomedical informatics researchers. The chatbot is designed to give new mothers personalized, evidence-based information and support in real time.
Waitlist Available
Has No Placebo
University of California San Diego
Have you considered Serzone clinical trials? We made a collection of clinical trials featuring Serzone, we think they might fit your search criteria.Go to Trials
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Akashic Records Sessions for Mental Health

18+
All Sexes
Palm City, FL
The goal of this clinical study is to learn the impact of two Akashic Records sessions on mental health symptoms in adults. We want to see how sessions are linked to stress, anxiety, and depression, and to resilience (ability to bounce back) and feelings of connectedness (to self, community, and humanity). Main questions this study will answer are: After two sessions, what is the impact on stress, anxiety, and depression? After two sessions, what is the impact on resilience and connectedness? How do participants describe their experience of the sessions? After two sessions, what are participants' views of their problems (insight), emotional experiences (impact) and observable behaviors in their daily life? What participants will do: Complete online surveys about their mood at four points: before the first session, before the second session, after the second session, and again 2 months later. Surveys include: DASS-21 (Depression, Anxiety, and Stress Scale) CD-RISC-10 (Connor-Davidson Resilience Scale) WATTS (Connectedness Scale) A short demographic form and satisfaction survey Attend two individual Akashic Records sessions (50-90 minutes each) over private video platform with a licensed clinical social worker (principal investigator) The first 50 participants will also join a one-hour interview with open ended questions with a licensed clinical social worker (co-investigator) about one week after the second session to share their experience in their own words. Who can take part: Adults ages 18 and older who can read and consent in English and who have experienced stress, anxiety, or low mood in the past year. How the research will happen: Sessions are held by secure video call. Participants will also complete private online surveys before, during, and after the sessions. Some participants may be invited to share their experiences in a one-on-one interview. All information is kept private and names are removed before analysis. Risks and benefits: Talking about personal topics may bring up strong emotions. Licensed clinicians conduct sessions, offer support, and provide referrals if needed. Possible benefits include new insights, greater peace or meaning, and improved coping; benefits are not guaranteed. Why this matters: Many people seek spiritual or transpersonal support for emotional concerns. This pilot study will provide early evidence on whether Akashic Records sessions may be a helpful, low-risk option and will guide future research.
Waitlist Available
Has No Placebo
Virtual/ No Physical FacilityCandice S Rasa, LCSW
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Virtual Reality Reward Training for Depression

18+
All Sexes
Los Angeles, CA
The purpose of this study is to compare the effects of enhanced Virtual Reality-Reward Training (eVR-RT) with an active control condition, Virtual Reality-Memory Training (VR-MT), on positive affect and other clinical symptoms. Enhanced VR-Reward Training is a novel intervention aimed at enhancing savoring of positive experiences among individuals with depression and low positive affect through guided imaginal recounting following immersion in positive VR experiences. The current study tests an enhanced version of this training using improved virtual reality technology. Target enrollment is 80 participants with low positive affect, depression, and impaired functioning, who are at least 18 years old, who will be randomly assigned to 7 weeks of either enhanced Virtual Reality-Reward Training (VR-RT) or Virtual Reality-Memory Training (VR-MT). Participants will complete in-person VR sessions, laboratory assessments, self-report questionnaires as part of the study. A subset of 8 participants randomly assigned to VR-RT will complete fMRI scans and EMA surveys. The total length of participation is around 3 months.
Phase 2
Recruiting
University of California, Los Angeles
Have you considered Serzone clinical trials? We made a collection of clinical trials featuring Serzone, we think they might fit your search criteria.Go to Trials
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Self-Help Intervention for Depression and PTSD

18+
All Sexes
Syracuse, NY
It is important to provide support and resources for the many post-9/11 Veterans with mental health symptoms and poor psychosocial functioning who do not engage in psychotherapy. One of the biggest reasons post-9/11 Veterans do not seek treatment is a preference to handle problems on their own. This study examines a self-help intervention that teaches Veterans healthy coping strategies they can use on their own and how to seek out recovery support services such as mental health treatment or whole-person care if they decide to do so in the future. This study will compare the impact of self-help and standard resources at improving mental health and resource utilization. Two hundred Veterans will complete 6 brief assessments across 40 weeks.
Waitlist Available
Has No Placebo
Syracuse VA Medical Center, Syracuse, NY (+1 Sites)Robyn L. Shepardson, PhD
Have you considered Serzone clinical trials? We made a collection of clinical trials featuring Serzone, we think they might fit your search criteria.Go to Trials
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