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What is Paxil Cr
ParoxetineThe Generic name of this drug
Treatment SummaryParoxetine, sold under the brand name Paxil, is a medication used to treat anxiety, depression, post-traumatic stress disorder, and symptoms of menopause. It is a type of selective serotonin reuptake inhibitor (SSRI), meaning it specifically affects serotonin levels in the brain. Paroxetine is usually well tolerated but can cause withdrawal symptoms when stopped. To reduce nausea, there is a controlled release formula of the drug available.
Paxilis the brand name
Paxil Cr Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Paxil
Paroxetine
1993
429
Approved as Treatment by the FDA
Paroxetine, also known as Paxil, is approved by the FDA for 2 uses which include Hot flashes and Hot Flashes .Hot flashes
Helps manage Menopause
Hot Flashes
Helps manage Vasomotor Symptoms Associated With Menopause
Effectiveness
How Paxil Cr Affects PatientsParoxetine is used to treat depression, anxiety, post-traumatic stress disorder, obsessive-compulsive disorder, and menopause symptoms by preventing the reabsorption of serotonin. It usually takes about 6 weeks for the effects to be felt. Taking it with other drugs that affect serotonin levels, like MAO inhibitors, can cause dangerous side effects. It is important to wait 2 weeks after discontinuing any MAO inhibitor before taking paroxetine.
How Paxil Cr works in the bodyParoxetine helps regulate serotonin levels in the body. It does this by blocking the serotonin (SERT) receptor from taking serotonin away from the synapse. This raises serotonin levels, which can relieve symptoms. Paroxetine has been proven to be more effective at blocking serotonin reuptake than other drugs in its class. The exact way Paroxetine treats menopausal symptoms is still unknown, but it may be related to how it affects temperature regulation. Paroxetine also has a mild effect on certain receptors in the body, including adrenergic, dopamine, histamine, and serotonin receptors. Its delayed effects may be
When to interrupt dosage
The suggested dosage of Paxil Cr is contingent upon the recognized situation, like Post Traumatic Stress Disorder, Depression and Irritable Bowel Syndrome (IBS). The measure of dosage may differ, depending on the approach of delivery (e.g. Oral or Capsule - Oral) noted in the table beneath.Condition
Dosage
Administration
Generalized Anxiety Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Irritable Bowel Syndrome
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Depression
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Hot Flashes
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Premature Ejaculation
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Panic Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Social Anxiety Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Obsessive-Compulsive Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Hot flashes
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Post Traumatic Stress Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Warnings
Paxil Cr has five contraindications, and thus should not be engaged when one is faced with the conditions in the subsequent table.Paxil Cr ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Serotonin Syndrome
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Paroxetine may interact with Pulse Frequency
Common Paxil Cr Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Paroxetine.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Paroxetine.
Acebutolol
Major
The metabolism of Acebutolol can be decreased when combined with Paroxetine.
Acetaminophen
Major
The metabolism of Acetaminophen can be decreased when combined with Paroxetine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Paroxetine is combined with Aclidinium.
Paxil Cr Toxicity & Overdose RiskThe most toxic dose of paroxetine for mice and rats is 350 mg/kg. The lowest reported fatal dose of paroxetine is 400 mg; the highest reported dose of paroxetine that someone has survived is 2000 mg. Symptoms of paroxetine overdose can include tiredness, fever, high blood pressure, fast heartbeat, nausea, vomiting, drowsiness, trembling, confusion, anxiety, headache, sweating, dilated pupils, seizures, tingling sensations, serotonin syndrome, muscle contraction, and changes in mental status. There is no known antidote for paroxetine overdose.
Paxil Cr Novel Uses: Which Conditions Have a Clinical Trial Featuring Paxil Cr?
539 active trials are currently being conducted to examine the utility of Paxil CR in Post Traumatic Stress Disorder, Premature Ejaculation and Menopausal symptoms.Condition
Clinical Trials
Trial Phases
Post Traumatic Stress Disorder
241 Actively Recruiting
Not Applicable, Early Phase 1, Phase 2, Phase 3, Phase 4, Phase 1
Generalized Anxiety Disorder
200 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 3, Phase 1, Early Phase 1
Depression
195 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1, Phase 3
Social Anxiety Disorder
22 Actively Recruiting
Not Applicable, Phase 2, Early Phase 1, Phase 3
Panic Disorder
15 Actively Recruiting
Not Applicable, Phase 2
Obsessive-Compulsive Disorder
16 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 1
Irritable Bowel Syndrome
8 Actively Recruiting
Not Applicable, Phase 4, Phase 2
Hot Flashes
0 Actively Recruiting
Premature Ejaculation
0 Actively Recruiting
Hot flashes
13 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Early Phase 1
Paxil Cr Reviews: What are patients saying about Paxil Cr?
5Patient Review
11/13/2014 Paxil has been a game-changer for me. I've suffered from depression since childhood, and this medication has helped alleviate many of the symptoms. I'm so grateful to have found something that helps me feel more like myself.
5Patient Review
7/19/2015 Paxil has been a life-saver for me. It's helped me manage my anxiety for 15 years without any negative side effects. I'm able to live a joyful and positive life thanks to this medication!
5Patient Review
4/7/2015 Paxil has been a game-changer for me. I haven't had a panic attack in 20 years, and even just forgetting to take it on vacation for 3 days brought the attacks back.
5Patient Review
9/23/2014 Paxil is an excellent drug for those suffering from OCD or panic disorder. I experienced very few side effects, and they were all manageable.
4.3Patient Review
6/15/2016 I come from a family with a history of anxiety, so my FNP put me on Paxil CR about 10 years ago. Over time, the dosage increased as needed. I was really struggling to function without the medication; however, it has helped me immensely and allowed me to enjoy life much more.
3.3Patient Review
10/14/2018 It took me an hour to ejaculate, but the results were worth it.
3Patient Review
7/28/2016 Though this medication helped me, I was still anxious. My doctor decided to switch me to Wellbutrin, but that turned out to be a mistake. I got very sick from it and had to withdraw from the Paxil. Be careful when changing medications!
3Patient Review
9/6/2018 I was convinced to take an SSRI in high school but Paxil had very little effect. The worst part was that it interfered with my sex life; I could barely ejaculate!
2.3Patient Review
1/25/2015 I've tried a lot of different antidepressants and, by far, Paxil was the worst experience. I constantly got migraines (even though I'd never had them before), slept for 16 hours a day, and couldn't focus or function when I was awake because of the headaches. There are so many better options out there than this one.
2Patient Review
4/15/2014 I found myself feeling really hyper one day, and then really down the next.
Patient Q&A Section about paxil cr
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Paxil CR used for?
"Paroxetine is a medication used to treat various forms of mental illness. These include depression, anxiety, panic attacks, and a severe form of premenstrual syndrome known as premenstrual dysphoric disorder. The drug works by correcting imbalances of the neurotransmitter serotonin in the brain."
Answered by AI
How long does it take for Paxil CR to work?
"In the first week or two, you may see some improvement in your sleep, energy levels, or appetite. This can be a good sign that the medication is working. However, it can take up to eight weeks for your mood and interest in activities to fully improve."
Answered by AI
Whats the difference between Paxil and Paxil CR?
"Paxil is a prescription medication that is used to treat depression, anxiety disorders, and other serious mental health problems. The medication is manufactured by GlaxoSmithKline and was the first medication to be approved for the treatment of social anxiety disorder (SAD). Paxil CR is the longer-acting, controlled-release version of the medication."
Answered by AI
What does the CR stand for in Paxil CR?
"Paxil and Paxil CR are indicated for the treatment of major depressive disorder, panic disorder and obsessive-compulsive disorder. Paxil was approved in May 1996."
Answered by AI