Bicillin L-A

Gas Gangrene, Botulism, Anthrax + 20 more

Treatment

20 Active Studies for Bicillin L-A

Treatment for

Gas Gangrene

What is Bicillin L-A

BenzylpenicillinThe Generic name of this drug

Treatment SummaryBenzylpenicillin (Penicillin G) is an antibiotic used to treat infections caused by certain types of bacteria. Natural penicillins are the best drugs to treat certain infections caused by susceptible gram positive aerobic organisms like streptococcus and staphylococcus bacteria. It is usually given intravenously or intramuscularly due to poor oral absorption. Benzylpenicillin can also be used as a preventative medication against certain types of bacteria. It may also be used to treat certain gram positive aerobic bacilli such as anthrax and diphtheria, as well as some infections caused by gram

Bicillin L-Ais the brand name

Bicillin L-A Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Bicillin L-A

Benzylpenicillin

1952

Effectiveness

How Bicillin L-A Affects PatientsPenicillin G is an antibiotic used to fight bacterial infections. It is part of a group of antibiotics known as penicillins. It works by stopping the bacteria from forming walls that protect and help them grow, and is effective against both gram-positive and gram-negative bacteria. Penicillin G is resistant to most beta-lactamases, which are enzymes used by bacteria to break down antibiotics.

How Bicillin L-A works in the bodyPenicillin G works by attaching to proteins inside the bacterial cell wall, stopping the cell wall from finishing its growth. This causes the cell to break apart, using enzymes that are naturally found in the cell. Penicillin G may also block an enzyme that helps keep the cell from breaking down.

When to interrupt dosage

The prescribed dosage of Bicillin L-A is contingent upon the diagnosed condition, such as rat bite fever, Haverhill fever and Actinomycosis. The amount of dosage is dependent upon the technique of administration (e.g. Intramuscular; Intravenous or Injection, suspension) as illustrated in the table below.

Condition

Dosage

Administration

Gas Gangrene

, 5000000.0 [iU], 20000000.0 [iU], 5000000.0 [USP'U], 1200000.0 [iU]/mL, 5000000.0 units, 1000000.0 units, 10000000.0 units, 500000.0 units, 600000.0 [iU]/mL, 2400000.0 [iU]/mL, 100000.0 [iU]/mL, 200000.0 [iU]/mL, 300000.0 [iU]/mL, 1000000.0 [iU], 900000.0 [iU]/mL, 500000.0 units/mL, 1200000.0 units/mL, 250000.0 units/mL, 900000.0 units/mL, 300000.0 units/mL

, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, suspension, Injection, suspension - Intramuscular, Intramuscular, Intramuscular; Intrapleural; Intrathecal; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intrapleural; Intrathecal; Intravenous, Intravenous, Powder, for solution - Intravenous, Powder, for solution - Intramuscular; Intravenous, Intramuscular; Intravenous; Topical, Powder, for solution - Intramuscular; Intravenous; Topical, Oral, Tablet - Oral, Tablet, Suspension - Intramuscular, Suspension, Suspension - Oral, Powder, for solution - Intramuscular, Injection, solution, Injection, solution - Intravenous, Injection, powder, for solution - Intravenous

Botulism

Bacterial Meningitis

Haverhill fever

Actinomycosis

Fusospirochetosis

rat bite fever

Meningitis, Meningococcal

Gram-Negative Bacterial Infections

Endocarditis

Acute Rheumatic Fever

Lockjaw

Pneumonia

Syphilis

Pericarditis

Communicable Diseases

Listeriosis

Sepsis

Diphtheria

Endocarditis

Warnings

Bicillin L-A has one contraindication. It should not be ingested when encountering any of the conditions outlined in the following table.Bicillin L-A Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Benzylpenicillin may interact with Pulse Frequency

There are 20 known major drug interactions with Bicillin L-A.

Common Bicillin L-A Drug Interactions

Drug Name

Risk Level

Description

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Benzylpenicillin.

Adefovir dipivoxil

Minor

The excretion of Adefovir dipivoxil can be decreased when combined with Benzylpenicillin.

Chlormadinone

Minor

The therapeutic efficacy of Chlormadinone can be decreased when used in combination with Benzylpenicillin.

Cidofovir

Minor

The excretion of Cidofovir can be decreased when combined with Benzylpenicillin.

Cloprostenol

Minor

The therapeutic efficacy of Cloprostenol can be decreased when used in combination with Benzylpenicillin.

Bicillin L-A Toxicity & Overdose RiskThe lowest toxic dose of penicillin in rats has been found to be 8900mg/kg. High concentrations of the drug in the cerebral spinal fluid can lead to convulsions, and prolonged use of high doses can cause a decrease in white blood cells.

Bicillin L-A Novel Uses: Which Conditions Have a Clinical Trial Featuring Bicillin L-A?

There are 85 active trials presently assessing the utility of Bicillin L-A in treating Pneumonia, Acute Rheumatic Fever and Gram-Negative Bacterial Infections.

Condition

Clinical Trials

Trial Phases

Pneumonia

22 Actively Recruiting

Not Applicable, Phase 3, Early Phase 1, Phase 2, Phase 1

Lockjaw

1 Actively Recruiting

Phase 4

Bacterial Meningitis

0 Actively Recruiting

Botulism

2 Actively Recruiting

Phase 1, Phase 2

Communicable Diseases

0 Actively Recruiting

Acute Rheumatic Fever

0 Actively Recruiting

Fusospirochetosis

0 Actively Recruiting

Meningitis, Meningococcal

0 Actively Recruiting

Anthrax

1 Actively Recruiting

Phase 2

Gram-Negative Bacterial Infections

1 Actively Recruiting

Phase 2

Gas Gangrene

0 Actively Recruiting

Empyema

0 Actively Recruiting

Listeriosis

0 Actively Recruiting

Actinomycosis

0 Actively Recruiting

Diphtheria

1 Actively Recruiting

Phase 4

rat bite fever

0 Actively Recruiting

Endocarditis

0 Actively Recruiting

Pericarditis

0 Actively Recruiting

Endocarditis

1 Actively Recruiting

Not Applicable

Sepsis

1 Actively Recruiting

Not Applicable

Bicillin L-A Reviews: What are patients saying about Bicillin L-A?

5Patient Review

12/16/2014

Bicillin L-A for Strep Throat and Tonsillitis

Even though it's expensive, this treatment is definitely worth it. My son felt much better the day after being injected with this antibiotic.

5Patient Review

11/4/2019

Bicillin L-A for Strep Throat

I had strep throat and was given amoxicillin, but it didn't seem to help after four days. So my doctor gave me this bicillin shot instead and I felt SO much better almost immediately! Not only did my sore throat get better, but my body aches went away too. The shot stung a bit, but it wasn't bad at all compared to how I was feeling before.

5Patient Review

4/9/2017

Bicillin L-A for Strep Throat

I found myself in the ER early Saturday morning with swollen glands, difficulty swallowing, and overall neck pain. The doctor diagnosed me with strep throat and gave me the option of an IM antibiotic along with a steroid pill. I felt better hours later, but experienced some stomach pain during the night and following day. The shot hurts, but it's better than having to swallow giant pills for 10 days.

5Patient Review

10/11/2021

Bicillin L-A for Strep Throat

I felt awful going in, but noticed a drastic improvement just four hours later. It was like night and day. The needle hurts a bit, but the pain is manageable and totally worth it when you're feeling better the next day.

5Patient Review

1/26/2011

Bicillin L-A for Strep Throat

I had a really severe strep infection and this medication cleared it up overnight. I woke up feeling great the next morning.

4.7Patient Review

8/4/2012

Bicillin L-A for Syphilis

This medication was very effective at clearing up my symptoms and reducing the levels of the virus in my blood. It took a few weeks to start working, but it was well worth the wait.

4.3Patient Review

2/23/2017

Bicillin L-A for Strep Throat

I was diagnosed with strep throat and given a shot. The treatment was pretty effective, though it did leave me sore the next day.

4Patient Review

2/16/2017

Bicillin L-A for Strep Throat

The shot was painful, but it took care of the strep throat within an hour. I'm really glad I got it.

3.3Patient Review

2/18/2012

Bicillin L-A for Strep Throat

I was given this injection at the ER after a strep test came back positive. I felt much better after 24 hours, although the injection site was sore for a couple days afterwards. I was also given oral steroids to relieve swelling in my throat. My family doctor prescribed 10 days of amoxicillin about 18 hours later; however, I have since developed diarrhea and feel like vomiting.

3.3Patient Review

7/12/2010

Bicillin L-A for Rheumatic Fever Prevention

It took a long time and multiple specialists to arrive at a diagnosis of Rheumatic Fever for my son, but the treatment plan of Bicillin LA shots every 4 weeks has been working so far. He says the shots are painful, but not as bad as living with the symptoms was.

3Patient Review

4/9/2013

Bicillin L-A for Strep Throat and Tonsillitis

My daughter had strep throat that was missed by our doctor the first week she had it. She was tested this week, and got an injection because she doesn't like taking medicine. Today, she is very sore from the shot, but her sore throat and vomiting are gone. Hopefully she will be able to walk tomorrow so she can go back to school; she has already missed five days.

2.3Patient Review

10/15/2015

Bicillin L-A for Early Stage of Syphilis with No Symptoms

I had a pretty bad experience with this treatment. I was given one shot for exposure to syphilis, and a few hours later I started running a fever and feeling flu-like symptoms. My friend found me at 1am in the ER covered in bags of ice, with a 105 degree fever and unresponsive. The Jarisch-herxheimer reaction almost killed me, and I spent 36 hours in the hospital under observation.

2.3Patient Review

1/18/2012

Bicillin L-A for Strep Throat

Cleared up the strep, but caused me to have a seizure (which I have never had before). It was a horrible experience. I couldn't get out of bed the entire next day. Felt like I had been hit by a truck. The vaccination site was extremely sore for a few days, and the shot in the buttocks was not a fun experience either...very painful.

2Patient Review

6/7/2015

Bicillin L-A for Strep Throat

I had a really terrible experience with this treatment. The shot was painful and didn't do anything. I went back to the doctor and argued for something else until they finally prescribed Clindamycin. Within 6-12 hours I could tell it was working better.

1.7Patient Review

8/5/2021

Bicillin L-A for Strep Throat

I received this shot in the ER and felt much better afterwards, but the next day my throat was worse than it had been before. I'm going back to the doctor tomorrow if it doesn't improve.

1.7Patient Review

5/5/2016

Bicillin L-A for Strep Throat and Tonsillitis

I received this treatment two days ago and I am still in an incredible amount of pain. It hurts to walk, and I feel like I got hit by a truck. I would never recommend this to anyone.

1.3Patient Review

3/19/2013

Bicillin L-A for Strep Throat

The pain was unbearable. She didn't give me the shot in my butt like I asked, but rather in my side which caused immense back and leg pain.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about bicillin l-a

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What's the difference between Bicillin CR and LA?

"Bicillin L-A is a recommended treatment for syphilis and upper respiratory tract infections caused by susceptible streptococci. The efficacy of Bicillin C-R for treating syphilis is unknown, but it is indicated for streptococcal infections of the skin and respiratory tract."

Answered by AI

Where is bicillin injection given?

"The recommended site for intramuscular injection in adults is the upper, outer quadrant of the buttock (dorsogluteal). In neonates, infants, and small children, the midlateral aspect of the thigh may be preferable. When doses are repeated, vary the injection site."

Answered by AI

How long does Bicillin L-A stay in your system?

"The blood levels may take up to 10 days to return to normal after 600,000 units have been administered, and up to 14 days after 1,200,000 units have been administered. Blood concentrations of 0.003 units per mL may still be detectable 4 weeks after 1,200,000 units have been administered."

Answered by AI

What is Bicillin L-A used for?

"This drug is used to treat infections caused by bacteria. It is also used to prevent certain infections such as rheumatic fever. This drug will not work against infections caused by viruses such as colds or flu."

Answered by AI

Clinical Trials for Bicillin L-A

Image of Public Health Sexual Health Clinic in Seattle, United States.

Have you considered Bicillin L-A clinical trials? We made a collection of clinical trials featuring Bicillin L-A, we think they might fit your search criteria.

Image of Ronald Reagan UCLA Medical Center in Los Angeles, United States.

Next Day Clinic for Patient Care

18+

All Sexes

Los Angeles, CA

"This trial is about a new clinic called the Next Day Clinic (NDC) that will be run by UCLA Health starting in July 2024. The clinic aims to improve patient care and safety while

Recruiting

Has No Placebo

Ronald Reagan UCLA Medical Center

Image of Geisinger 65-Forward, Buckhorn in Bloomsburg, United States.

Osteopathic Manipulative Therapy for Respiratory Diseases

65 - 100

All Sexes

Bloomsburg, PA

This trial aims to investigate whether Osteopathic Manipulative Therapy (OMT) can help patients with respiratory illnesses and their symptoms. The study will see if adding OMT to standard care can reduce symptoms

Waitlist Available

Has No Placebo

Geisinger 65-Forward, BuckhornMargaret Moore, DO

Image of Boston Medical Center in Boston, United States.

Recovery Management Checkups for Opioid Use Disorder

18 - 65

All Sexes

Boston, MA

This trial is testing a new version of a treatment program for opioid use disorder (OUD) called Recovery Management Checkups (RMC) that is tailored for people who have been hospitalized with serious injection

Waitlist Available

Has No Placebo

Boston Medical CenterSimeon Kimmel, MD

Antibody Test for Syphilis

Any Age

All Sexes

Ottawa, Canada

"This trial is testing a new syphilis antibody test called the Multiplo Complete Syphilis Antibody Test in an urban STI clinic. They will be using a finger-prick blood sample to

Waitlist Available

Has No Placebo

Sexual Health ClinicPatrick O'Byrne, PhDMedMira Laboratories Inc.

Have you considered Bicillin L-A clinical trials? We made a collection of clinical trials featuring Bicillin L-A, we think they might fit your search criteria.

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Mobile Clinic Services for Women Who Inject Drugs

18+

All Sexes

Seattle, WA

This trial will set up a pop-up clinic in a van near areas where women who inject drugs gather in north Seattle. The clinic will offer HIV prevention medication, opioid use disorder medication, and testing for

Recruiting

Has No Placebo

Harborview Medical CenterMaria Corcorran, MD, MPH

Image of California Department of Public Health in Richmond, United States.

Botulinum Vaccine for Botulism

18 - 69

All Sexes

Richmond, CA

This trial will test safety, tolerability, and effectiveness of a botulinum vaccine in healthy participants, with a 6-month follow-up.

Phase 2

Waitlist Available

Has No Placebo

California Department of Public Health

Image of University of Utah in Salt Lake City, United States.

Antibiotic Stewardship at Discharge for Pneumonia

18+

All Sexes

Salt Lake City, UT

This trial will test if an antibiotic stewardship approach tailored to a hospital's needs can reduce antibiotic overuse at discharge in hospitalized patients with CAP or UTI.

Waitlist Available

Has No Placebo

University of UtahValerie M Vaughn, MD

Image of University of Michigan in Ann Arbor, United States.

Motivational Interviewing for STI Screening

18+

All Sexes

Ann Arbor, MI

This trial will investigate if gay/bi men w/ HIV are willing to collect & return bacterial STI specimens for testing when combined with live AV conferencing support, to prevent health complications & reduce transmissions.

Waitlist Available

Has No Placebo

University of MichiganAkshay Sharma, PhD

Have you considered Bicillin L-A clinical trials? We made a collection of clinical trials featuring Bicillin L-A, we think they might fit your search criteria.