Bridion

Operative Surgery, Neuromuscular blockade caused by vecuronium bromide
Treatment
20 Active Studies for Bridion

What is Bridion

SugammadexThe Generic name of this drug
Treatment SummarySugammadex (also known as Bridion) is a medication used to reverse the effects of certain drugs that cause temporary paralysis during surgery. These drugs, rocuronium bromide and vecuronium bromide, are used to help with general anesthesia, ventilation, or tracheal intubation. Sugammadex helps to reverse the effects of these drugs faster and allow patients to recover sooner after surgery. It was approved by the FDA in 2015 and is marketed by Merck Sharp and Dohme.
Bridionis the brand name
Bridion Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Bridion
Sugammadex
2015
3

Effectiveness

How Bridion works in the bodySugammadex is a modified sugar molecule. It forms strong bonds with certain drugs used to stop nerves from working, like rocuronium. This causes the drug to move out of the nerve and into the bloodstream, quickly reversing its effects. Sugammadex then binds tightly to any remaining drug in the bloodstream, helping it leave the nerve and enter the bloodstream.

When to interrupt dosage

The suggested dose of Bridion is contingent upon the diagnosed condition. The amount likewise relies upon the mode of delivery as detailed in the accompanying table.
Condition
Dosage
Administration
Operative Surgery
, 100.0 mg/mL
, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous
Neuromuscular blockade caused by vecuronium bromide
, 100.0 mg/mL
, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous

Warnings

There are 20 known major drug interactions with Bridion.
Common Bridion Drug Interactions
Drug Name
Risk Level
Description
Chlormadinone
Moderate
The serum concentration of Chlormadinone can be decreased when it is combined with Sugammadex.
Cyproterone acetate
Moderate
The serum concentration of Cyproterone acetate can be decreased when it is combined with Sugammadex.
Demegestone
Moderate
The serum concentration of Demegestone can be decreased when it is combined with Sugammadex.
Desogestrel
Moderate
The serum concentration of Desogestrel can be decreased when it is combined with Sugammadex.
Dienogest
Moderate
The serum concentration of Dienogest can be decreased when it is combined with Sugammadex.
Bridion Toxicity & Overdose RiskPeople with severely reduced kidney function (creatinine clearance below 30 mL/min) should not take this drug, as their bodies cannot properly clear it from their system and there is not enough evidence about its safety for this group.

Bridion Novel Uses: Which Conditions Have a Clinical Trial Featuring Bridion?

No current trials are being conducted to explore the potential of Bridion to abate Neuromuscular blockade caused by vecuronium bromide.
Condition
Clinical Trials
Trial Phases
Neuromuscular blockade caused by vecuronium bromide
0 Actively Recruiting
Operative Surgery
75 Actively Recruiting
Phase 3, Not Applicable, Phase 4, Phase 1, Phase 2, Early Phase 1

Patient Q&A Section about bridion

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Bridion used for?

"BRIDION is an injection that helps to negate the effects of certain neuromuscular blocking drugs, rocuronium bromide, and vecuronium bromide. These drugs are used during particular types of surgeries on adults."

Answered by AI

What is sugammadex used for?

"This medication, SUGAMMADEX, is used to reverse the effects of the muscle relaxants rocuronium and vecuronium. These medicines are given to patients during surgery."

Answered by AI

How long does it take for sugammadex to wear off?

"Relaxation might take up to 4 minutes to start, and the effects might only last for 15 minutes."

Answered by AI

What are the side effects of sugammadex?

"The most common adverse reactions to sugammadex are vomiting, dry mouth, tachycardia, dizziness, and hypotension. However, there have been reports of severe hypotension following the administration of sugammadex, with systolic blood pressure falling to 50 mmHg or below."

Answered by AI

Clinical Trials for Bridion

Image of Washington University / Barnes Jewish Hospital in St Louis, United States.

AI-Driven Clinical Decision Support for Surgery

18+
All Sexes
St Louis, MO
20 million patients have surgery in the United States every year, with approximately 1 million of those patients requiring life-saving blood transfusion. Presurgical preparation for transfusion is important to allow for safe and timely transfusion during surgery; however, excessive preparation is unfortunately common, costly, and contributes to blood waste. This study aims to evaluate an intelligent clinical decision support system that helps clinicians prepare blood for patients who are likely to need it, while avoiding excessive preparation for patients who don't, potentially improving patient safety while reducing blood waste and healthcare costs.
Recruiting
Has No Placebo
Washington University / Barnes Jewish Hospital
Image of UPMC Shadyside Hospital in Pittsburgh, United States.

Bright Green Light Therapy for Postoperative Pain

18+
All Sexes
Pittsburgh, PA
This is an unblinded, parallel group randomized controlled trial to evaluate bright green light as an adjunct therapy after surgery at UPMC Shadyside. The primary outcome measure will be pain intensity with secondary outcome measures including opioid requirements, sleep quality, mood, and overall post-operative recovery. Specific aims/hypotheses for this study are as follows: Aim 1: To assess bright green light therapy's potential as a complementary post-operative analgesic strategy in patients recovering from surgery Hypothesis 1: Participants exposed to bright green light, in comparison to dim white (ambient) light, will have improved postoperative pain scores and lower opioid use. Aim 2: To examine the impact of bright green light therapy on patient-centered measures of post-operative recovery that may be related to improved circadian function. Hypothesis 2: Participants exposed to bright green light, in comparison to dim white (ambient) light, will have improved quality of post-operative recovery, enhanced sleep, and reduced anxiety and depression.
Waitlist Available
Has No Placebo
UPMC Shadyside HospitalRebecca Kotcher, MD
Image of Walter Reed National Military Medical Center in Bethesda, United States.

Corticosteroid Injections for Osteoarthritis

18+
All Sexes
Bethesda, MD
The goal of this clinical trial is to find out which type of steroid medicine, when added to a standard pain-control injection during total knee replacement surgery, works best at reducing pain, limiting opioid use, and improving recovery in adults undergoing surgery for severe knee arthritis or injury. The main questions it aims to answer are: Does adding a steroid to the injection improve pain control and reduce opioid use after surgery? Is the newer extended-release steroid (Zilretta) more effective and safer-especially for patients with diabetes-than the traditional steroid (methylprednisolone)? Researchers will compare: Standard pain-control injection alone Standard injection plus methylprednisolone Standard injection plus Zilretta to see which option provides better pain relief, less opioid use, and improved knee function. (Patients with diabetes or prediabetes will only be in the standard injection or Zilretta groups so researchers can study whether Zilretta is safer for blood sugar control.) Participants will: Be randomly assigned to one of the study groups during their total knee replacement surgery Receive the assigned pain-control injection around the knee joint Be followed after surgery to measure: Pain levels Opioid pain medication use Knee movement (range of motion) Whether another procedure (such as manipulation under anesthesia) is needed if the knee becomes too stiff Patient-reported outcome surveys about pain and function
Phase 2 & 3
Waitlist Available
Walter Reed National Military Medical CenterJohn P Cody, MD
Have you considered Bridion clinical trials? We made a collection of clinical trials featuring Bridion, we think they might fit your search criteria.Go to Trials
Image of Nationwide Children's Hospital in Columbus, United States.

Surface Electromyography for Surgery

No minimum age - 21
All Sexes
Columbus, OH
The investigators are studying a type of technology that is already used called surface electromyography (EMG). This measures and records electrical activity using sensor stickers in a non-invasive way. The purpose of this study is to use a prototype/test surface EMG machine to measure how well regional anesthesia (nerve block) is working. This device is non-invasive and being used for research use as an unapproved medical device. The information may teach us how to give nerve blocks more safely and effectively. Study participation: Subjects having surgery will have the surface EMG sensor stickers placed on their arms or legs before surgery. These will stay on during surgery and for part of recovery. Study visits: The study will consist of 1 visit that starts in the pre-operative area, through the surgery, and for part of recovery time after surgery.
Waitlist Available
Has No Placebo
Nationwide Children's HospitalGrant Heydinger, MD
Image of UC Davis Dermatology in Sacramento, United States.

Ethyl Chloride Spray for Pain Reduction in Surgery

18+
All Sexes
Sacramento, CA
Fear of needles is a well-documented issue that affects many patients. This fear may cause significant anxiety in various medical situations, including in the dermatology office 1. If not properly managed, needle phobia can persist, affecting a patient's experience during each visit. This effect may compound and lead to avoidance behaviors that can delay necessary treatments 2. This issue is particularly relevant in a Mohs micrographic surgery (MMS) clinic where each patient experiences several painful needle injections before the day is over. Ethyl chloride is gaining popularity among dermatologists for its routine use in clinical practice due to its anesthetic and antiseptic properties, especially as a pre-injection agent. Research indicates that cryotherapy or pre-cooling the skin before administering a local anesthetic may offer benefits over topical anesthetics, such as enhanced pain relief, quicker onset, and better patient compliance 3,4. However, to our knowledge, no studies have specifically examined the effectiveness of pre-cooling with ethyl chloride prior to Mohs micrographic surgery. To address this gap, we're conducting a trial aimed at evaluating the impact of pre-cooling with ethyl chloride on pain perception in adult patients undergoing Mohs micrographic surgery with local anesthetic injections. The trial is a single-center, split-body study. The split-body design will involve dividing the surgical site into two equal halves, with one half (right side relative to patient) designated as the treatment side (receiving ethyl chloride spray prior to lidocaine injection) and the other as the control side (no ethyl chloride spray prior to injection). During the procedure, the participant will be asked to rate the pain associated with the needle injection AND the pain from infiltration of anesthetic from each side of the wound using the visual analog scale (VAS) scoring system (1 = no pain, 10 = most amount of pain possible). The results of the study will help us better understand how to mitigate pain and anxiety for patients requiring MMS.
Phase < 1
Recruiting
UC Davis Dermatology
Have you considered Bridion clinical trials? We made a collection of clinical trials featuring Bridion, we think they might fit your search criteria.Go to Trials
Image of University Health Network in Toronto, Canada.

Sleep Prehabilitation for Surgery

18+
All Sexes
Toronto, Canada
The goal of this clinical trial is to learn if changing sleep behaviour can improve sleep health in patients undergoing prehabilitation before elective surgery. Prehabilitation is the use of exercise, nutrition, and psychological support before surgery to improve recovery from surgery. The main questions it aims to answer are: Does changing sleep behaviour improve sleep before surgery? Does changing sleep behaviour improve recovery after surgery? Researchers will compare participants who receive sleep support with participants who do not receive sleep support to see if it improves sleep health and recovery from surgery. Participants will be asked to attend 4 meetings with the research team to learn how they can improve their sleep. They will use questionnaires, a diary, and a wearable tracker to record their sleep.
Recruiting
Has No Placebo
University Health NetworkIan Randall, MD
Image of The Ottawa Hospital in Ottawa, Canada.

Blood Transfusion Strategies for Surgery

18+
All Sexes
Ottawa, Canada
The goal of this pilot clinical trial is to learn if it is achievable to conduct a large-scale clinical trial whereby, the investigators will compare two ways of deciding when to give a blood transfusion during surgery. Participants in this study are adults undergoing surgery with a risk of significant blood loss. The main question it aims to answer is: * Is a trial designed to definitively test and compare two different red blood cell transfusion strategies feasible? Participants will: * Receive blood transfusions during surgery based on a higher (less than 90 g/L) or a lower (less than 70 g/L) hemoglobin value. * Complete questionnaires at 30 and 90 days after surgery.
Recruiting
Has No Placebo
The Ottawa HospitalGuillaume Martel, MD, MSc, FRCSC, FACS
Have you considered Bridion clinical trials? We made a collection of clinical trials featuring Bridion, we think they might fit your search criteria.Go to Trials
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