Azelastine Hydrochloride

Blepharitis allergic, Rhinitis, Vasomotor, Hay Fever + 6 more

Treatment

1 Active Study for Azelastine Hydrochloride

What is Azelastine Hydrochloride

Azelastine

The Generic name of this drug

Treatment Summary

Azelastine is a medication used to treat allergic and non-allergic rhinitis and allergic conjunctivitis. It is available as a nasal spray and an ophthalmic solution. The drug is a racemic mixture, but both enantiomers have equal effectiveness. Azelastine was approved by the FDA in 1996 and is also available in combination with fluticasone propionate as a nasal spray known as Dymista. This product is approved for people 6 years of age and older who have seasonal allergies.

Astelin

is the brand name

image of different drug pills on a surface

Azelastine Hydrochloride Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Astelin

Azelastine

1996

56

Effectiveness

How Azelastine Hydrochloride Affects Patients

Azelastine works by blocking the effects of histamine, providing relief from allergy symptoms. When taken in nasal or eye drop form, it will start working within 15 minutes and last for up to 12 hours. The peak effects usually occur 4-6 hours after taking the initial dose.

How Azelastine Hydrochloride works in the body

Azelastine works by blocking histamine H1-receptors, which are found on nerve endings, smooth muscle cells, and glandular cells. When allergens are present in sensitized individuals, histamine is released and binds to these receptors. This contributes to allergy symptoms like itching, sneezing, and congestion. Azelastine also helps to stabilize mast cells, prevent the release of other inflammation-causing substances, and reduce substances that cause nasal itching and sneezing.

When to interrupt dosage

The measure of Azelastine Hydrochloride is contingent upon the recognized malady, including Hay Fever, Disorder of eye and Keratoconjunctivitis. The extent of dosage fluctuates as per the technique of delivery (e.g. Nasal or Solution / drops) featured in the table beneath.

Condition

Dosage

Administration

Keratoconjunctivitis

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops - Intraocular, Solution / drops, Spray, Spray - Nasal, Solution / drops - Ophthalmic, Ophthalmic

Administration, Intranasal

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops - Intraocular, Solution / drops, Spray, Spray - Nasal, Solution / drops - Ophthalmic, Ophthalmic

allergic eye disorders

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops - Intraocular, Solution / drops, Spray, Spray - Nasal, Solution / drops - Ophthalmic, Ophthalmic

Rhinitis, Vasomotor

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops - Intraocular, Solution / drops, Spray, Spray - Nasal, Solution / drops - Ophthalmic, Ophthalmic

Blepharitis allergic

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops - Intraocular, Solution / drops, Spray, Spray - Nasal, Solution / drops - Ophthalmic, Ophthalmic

Rhinitis, Allergic

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops - Intraocular, Solution / drops, Spray, Spray - Nasal, Solution / drops - Ophthalmic, Ophthalmic

Allergy to Tree Pollen

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops - Intraocular, Solution / drops, Spray, Spray - Nasal, Solution / drops - Ophthalmic, Ophthalmic

Hay Fever

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops - Intraocular, Solution / drops, Spray, Spray - Nasal, Solution / drops - Ophthalmic, Ophthalmic

Allergic Conjunctivitis (AC)

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops - Intraocular, Solution / drops, Spray, Spray - Nasal, Solution / drops - Ophthalmic, Ophthalmic

Warnings

There are 20 known major drug interactions with Azelastine Hydrochloride.

Common Azelastine Hydrochloride Drug Interactions

Drug Name

Risk Level

Description

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Azelastine.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Azelastine.

Brigatinib

Major

The metabolism of Brigatinib can be decreased when combined with Azelastine.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Azelastine.

Copanlisib

Major

The metabolism of Copanlisib can be decreased when combined with Azelastine.

Azelastine Hydrochloride Toxicity & Overdose Risk

It is unlikely that taking too much of the azelastine drug through the nose or eyes will cause any serious harm, other than making you more drowsy. If you do take too much, supportive measures should be taken. These products should be kept away from children, as taking too much orally can cause serious side effects in kids. The toxic dose of azelastine in rats is 580 mg/kg.

image of a doctor in a lab doing drug, clinical research

Azelastine Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Azelastine Hydrochloride?

Currently, nine investigations are underway to evaluate the effectiveness of Azelastine Hydrochloride via Intranasal Administration to combat Allergic Blepharitis and Ocular Disorders.

Condition

Clinical Trials

Trial Phases

Rhinitis, Vasomotor

0 Actively Recruiting

Administration, Intranasal

0 Actively Recruiting

Keratoconjunctivitis

0 Actively Recruiting

Hay Fever

0 Actively Recruiting

Allergy to Tree Pollen

0 Actively Recruiting

Allergic Conjunctivitis (AC)

1 Actively Recruiting

Phase 2

Rhinitis, Allergic

0 Actively Recruiting

allergic eye disorders

0 Actively Recruiting

Blepharitis allergic

0 Actively Recruiting

Azelastine Hydrochloride Reviews: What are patients saying about Azelastine Hydrochloride?

5

Patient Review

2/18/2022

Azelastine Hydrochloride for Inflammation of the Nose due to an Allergy

I can't believe how well this nasal spray worked for me! I'm 60 years old and have suffered from allergies my whole life, but this is the best medication I've ever used.

5

Patient Review

3/5/2022

Azelastine Hydrochloride for Vasomotor Rhinitis

Almost immediate results if you follow the directions. To those complaining about the taste, read the label!

5

Patient Review

4/8/2022

Azelastine Hydrochloride for Seasonal Runny Nose

After taking the second dose, I felt a bit chilly.

4.3

Patient Review

3/30/2022

Azelastine Hydrochloride for Inflammation of the Nose due to an Allergy

I found this to work well for sinus and ocular pressure. It dried out my sinuses and helped thin the mucus so that it could pass more easily. I liked it for seasonal use in teens. It also worked well in combination with antibiotics for ear or sinus infections.The drawbacks are the foul taste and burning, but for me it works better than flonase. I don't really feel tired, at most there's a small buzz and reduced reaction time.

4.3

Patient Review

5/21/2022

Azelastine Hydrochloride for Vasomotor Rhinitis

I've found this to be an effective treatment for post-nasal drip and inflammation. My sinuses feel lighter and I'm sleeping better at night. The only downside is that during the day I sometimes find it hard to move because of the lethargy, but overall I'm grateful for a product that actually works.

4

Patient Review

7/5/2021

Azelastine Hydrochloride for Inflammation of the Nose due to an Allergy

This helped me a lot with post-nasal drip. The taste isn't great, but it's worth it. Just remember to look down for several minutes after spraying into your nose.

3.3

Patient Review

3/8/2022

Azelastine Hydrochloride for Inflammation of the Nose due to an Allergy

I have never felt so drowsy in my life. It was like taking sleeping pills. I couldn't figure out why I was so sleepy while driving and ended up going to bed around 5pm. The next day, I woke up at 6am feeling slightly tired. I would not recommend this spray to anyone.

3

Patient Review

6/16/2022

Azelastine Hydrochloride for Inflammation of the Nose due to an Allergy

I felt relief immediately, which was great. There was an aftertaste that I didn't love, but it wasn't a dealbreaker. A few days in, though, I developed really bad itching in my hands that made the treatment unbearable.

2.3

Patient Review

3/25/2022

Azelastine Hydrochloride for Inflammation of the Nose due to an Allergy

The burning sensation in my nostril has gotten worse since I started using this product. I would not recommend it to anyone!

2.3

Patient Review

11/9/2021

Azelastine Hydrochloride for Inflammation of the Nose due to an Allergy

While this did help alleviate some symptoms, it unfortunately also caused my blood pressure and heart rate to increase. If you have any problems with arrhythmia, I'd recommend avoiding this treatment.

1.7

Patient Review

6/27/2022

Azelastine Hydrochloride for Inflammation of the Nose due to an Allergy

Azelastine unfortunately gave me headaches, so I had to stop using it after only a week. Additionally, everything started smelling strange and tasting terrible. This effect has persisted for a couple months now, and I'm really worried that my sense of smell and taste will never go back to normal. It's driving me crazy not being able to enjoy food like I used to.

1.3

Patient Review

12/30/2021

Azelastine Hydrochloride for Inflammation of the Nose due to an Allergy

I've tried using this medication for over a year now, and it's been an awful experience. I get horrible sneezing fits, nasal discharge, joint pain, a crawling skin sensation, and a scorched throat that lasts for days. And when the medicine finally kicks in, the relief doesn't last long. Do not recommend.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about azelastine hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is azelastine hydrochloride used for?

"Azelastine nasal spray can help relieve symptoms of seasonal or perennial allergic rhinitis (hay fever), vasomotor rhinitis, or other upper respiratory allergies. Azelastine is an antihistamine."

Answered by AI

What are the side effects of azelastine hydrochloride?

"Some potential side effects of this medication are a bitter taste in the mouth, drowsiness, tiredness, nasal discomfort, sneezing fits, cough, nose bleeds, runny nose, dry mouth, headache, or red eyes. If you experience any of these side effects, tell your doctor or pharmacist."

Answered by AI

Is azelastine HCL a steroid?

"Though azelastine nasal spray is not as strong as intranasal corticosteroids in terms of anti-inflammatory effect, it is still a non-steroidal treatment that has some advantages in the treatment of SAR."

Answered by AI

Is azelastine HCL the same as Flonase?

"Both medications are used to treat allergies, but they work differently.

Are Azelastine (nasal) and Flonase the same medication?

No, Azelastine (nasal) and Flonase are two different medications."

Answered by AI

Clinical Trials for Azelastine Hydrochloride