Carafate

Mucositis, Curling Ulcer, Indigestion + 9 more
Treatment
2 FDA approvals
20 Active Studies for Carafate

What is Carafate

SucralfateThe Generic name of this drug
Treatment SummarySucralfate is a medication used to protect cells in the gastrointestinal tract from damage caused by irritants like stomach acid, bile salts, alcohol, and aspirin. It is used to treat and prevent a range of gastrointestinal diseases such as duodenal ulcers, gastroesophageal reflux disease (GERD), gastritis, peptic ulcer disease, and stress ulcers. It is generally thought to be a safe drug with few side effects and is available in both tablet and suspension forms. Sucralfate was approved by the FDA in 1982 for tablet form and in 1994 for suspension form.
Carafateis the brand name
image of different drug pills on a surface
Carafate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Carafate
Sucralfate
1981
91

Approved as Treatment by the FDA

Sucralfate, otherwise known as Carafate, is approved by the FDA for 2 uses like active Duodenal ulcer and Duodenal Ulcer .
active Duodenal ulcer
Duodenal Ulcer

Effectiveness

How Carafate Affects PatientsThis drug helps heal duodenal ulcers by forming a protective barrier between the gastrointestinal tract and the substances that cause inflammation. It also increases the amount of growth factors and prostaglandins in the area, which help to heal the tissue lining the gastrointestinal tract.
How Carafate works in the bodySucralfate is used to help heal duodenal ulcers, but its exact mechanism of action is not yet known. It appears to form a protective barrier over the ulcer, blocking stomach acid and pepsin from damaging the tissue. It also increases levels of healing growth factors and prostaglandins in the area, and it is believed that it might also trap bile salts, which can cause further damage to the ulcer.

When to interrupt dosage

The recommended measure of Carafate is contingent upon the diagnosed condition, for example, Healing, Mucositis and Indigestion. Dosage varies in accordance with the approach of delivery outlined in the table beneath.
Condition
Dosage
Administration
Mucositis
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
Tablet, Tablet - Oral, , Oral, Suspension - Oral, Suspension, Cream - Topical, Cream, Topical
Curling Ulcer
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
Tablet, Tablet - Oral, , Oral, Suspension - Oral, Suspension, Cream - Topical, Cream, Topical
Indigestion
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
Tablet, Tablet - Oral, , Oral, Suspension - Oral, Suspension, Cream - Topical, Cream, Topical
Gastritis
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
Tablet, Tablet - Oral, , Oral, Suspension - Oral, Suspension, Cream - Topical, Cream, Topical
Duodenal Ulcer
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
Tablet, Tablet - Oral, , Oral, Suspension - Oral, Suspension, Cream - Topical, Cream, Topical
Healing
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
Tablet, Tablet - Oral, , Oral, Suspension - Oral, Suspension, Cream - Topical, Cream, Topical
Chemotherapy
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
Tablet, Tablet - Oral, , Oral, Suspension - Oral, Suspension, Cream - Topical, Cream, Topical
Stomach Ulcer
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
Tablet, Tablet - Oral, , Oral, Suspension - Oral, Suspension, Cream - Topical, Cream, Topical
Peptic Ulcer
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
Tablet, Tablet - Oral, , Oral, Suspension - Oral, Suspension, Cream - Topical, Cream, Topical
Stress Ulcers
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
Tablet, Tablet - Oral, , Oral, Suspension - Oral, Suspension, Cream - Topical, Cream, Topical
Anti-platelet Therapy
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
Tablet, Tablet - Oral, , Oral, Suspension - Oral, Suspension, Cream - Topical, Cream, Topical
Heartburn
, 1000.0 mg, 100.0 mg/mL, 1000.0 mg/mL, 1.8 mg/mL
Tablet, Tablet - Oral, , Oral, Suspension - Oral, Suspension, Cream - Topical, Cream, Topical

Warnings

Carafate Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Sucralfate may interact with Pulse Frequency
There are 20 known major drug interactions with Carafate.
Common Carafate Drug Interactions
Drug Name
Risk Level
Description
Deferasirox
Major
Sucralfate can cause a decrease in the absorption of Deferasirox resulting in a reduced serum concentration and potentially a decrease in efficacy.
Raltegravir
Major
Sucralfate can cause a decrease in the absorption of Raltegravir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Technetium Tc-99m oxidronate
Major
The serum concentration of Technetium Tc-99m oxidronate can be increased when it is combined with Sucralfate.
Abacavir
Minor
Sucralfate may decrease the excretion rate of Abacavir which could result in a higher serum level.
Abafungin
Minor
Sucralfate can cause a decrease in the absorption of Abafungin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Carafate Toxicity & Overdose RiskTaking too much sucralfate is unlikely to cause death, but may lead to constipation. Pregnant women should use this drug only if it is necessary for their health—studies on animals have not shown any harm to fetuses. It is currently unclear if this drug is excreted in breast milk, so caution should be taken when using it while nursing. No signs of cancer have been found in animals given up to 12 times the recommended human dose.
image of a doctor in a lab doing drug, clinical research

Carafate Novel Uses: Which Conditions Have a Clinical Trial Featuring Carafate?

Currently, there are 46 active clinical trials assessing the therapeutic potential of Carafate in managing Heartburn, Indigestion and Anti-platelet Therapy.
Condition
Clinical Trials
Trial Phases
Chemotherapy
4 Actively Recruiting
Phase 1, Phase 3, Not Applicable
Peptic Ulcer
0 Actively Recruiting
Curling Ulcer
0 Actively Recruiting
Indigestion
6 Actively Recruiting
Phase 3, Not Applicable, Phase 2
Stress Ulcers
0 Actively Recruiting
Duodenal Ulcer
0 Actively Recruiting
Anti-platelet Therapy
0 Actively Recruiting
Gastritis
0 Actively Recruiting
Stomach Ulcer
2 Actively Recruiting
Phase 4, Not Applicable
Healing
0 Actively Recruiting
Heartburn
12 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Mucositis
1 Actively Recruiting
Not Applicable

Carafate Reviews: What are patients saying about Carafate?

5Patient Review
11/5/2016
Carafate for Inflammation of Esophagus from Backflow of Stomach Acid
Carafate has been a godsend. I've suffered from reflux for years, to the point where it was difficult to swallow. All medications gave me diarrhea- until Carafate.
5Patient Review
3/26/2019
Carafate for Heartburn
Carafate has made an incredible difference for me-- I haven't experienced any reflux and I'm able to eat without feeling sick constantly.
5Patient Review
5/31/2019
Carafate for Medication Treatment for Healing Stomach Ulcer
Sucrafate has been a game changer for me and my stomach problems. It's bland, easy to take without water, and really works fast. I'm so grateful to have found this medication.
5Patient Review
3/21/2015
Carafate for Condition in which Stomach Acid is Pushed Into the Esophagus
I unfortunately always feel nauseous after taking this medication, to the point where I have difficulty eating.
5Patient Review
12/3/2015
Carafate for Condition in which Stomach Acid is Pushed Into the Esophagus
Carafate is a great medication for those with hiatal hernias and GERD. It's not the most pleasant tasting drug, but it beats having GERD symptoms!
4.7Patient Review
12/15/2016
Carafate for Inflammation of Esophagus from Backflow of Stomach Acid
This drug helped more than all the other PPI medications I was taking.
3Patient Review
5/5/2022
Carafate for Inflammation of Esophagus from Backflow of Stomach Acid
I have GERD and gastritis, among other digestive issues. After eating poorly for a few days, I had a bad case of reflux and pain. This treatment usually works after 5 days, but this time it took 2 weeks to give me relief. It causes me serious constipation but it’s better than the gastritis. If you use it, make sure you take high dose vitamins especially Bs and calcium as it blocks nutrients and take any other meds 2 hrs after using .
2Patient Review
1/6/2015
Carafate for Heartburn
I've had Psoriatic Arthritis for 23 years and my rheumatologist prescribed Carafate to prevent an ulcer. I feel it has done me much good since I've had to take NSAIDs so long in order to walk and work.
2Patient Review
4/20/2015
Carafate for Condition in which Stomach Acid is Pushed Into the Esophagus
Despite taking this medicine for a week, I started having constipation. Finally had to quit because it "paralyzed" my colon and I was unable to have a bowel movement (BM). It took 3 days of Milk of Magnesia and another week before I was able to go - then developed crampy diarrhea. I will NEVER use Carafate again!!!!
1.7Patient Review
1/15/2019
Carafate for Condition in which Stomach Acid is Pushed Into the Esophagus
I was prescribed this for my acid reflux, but it made me feel nauseous and bloated. It also caused constipation, so I stopped taking it.
1Patient Review
6/5/2018
Carafate for Condition in which Stomach Acid is Pushed Into the Esophagus
Unfortunately, I had a really severe allergic reaction after only two doses of this medication.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about carafate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long does it take for Carafate to work?

"Before taking Carafate, it is important to speak with a doctor. They will explain how long it may take to see the full benefits of the medicine. In some cases, it may only take a few weeks to see results, while in others it may take up to two months. It is important to follow the doctor's instructions and take the medicine for the full prescribed length of time, even if symptoms improve quickly. Once the active ulcer has healed, the doctor may want the patient to continue taking Carafate at a lower dose."

Answered by AI

What symptoms does Carafate help?

"Reflux esophagitis is the inflammation of the esophagus from the backflow of stomach acid. Gastroesophageal reflux disease is a stomach ulcer. The medication treatment for healing a stomach ulcer is an ulcer of the duodenum. The medication treatment for healing an ulcer of the duodenum is stress ulcer prevention."

Answered by AI

Is Carafate an antacid?

"Sucralfate is a medication used to treat duodenal ulcers. It works by healing the ulcer, but cannot be used to prevent future ulcers from occurring."

Answered by AI

What is Carafate used for?

"This medication is used to treat and prevent ulcers in the intestines. Sucralfate coats and protects ulcers, which helps them heal more quickly."

Answered by AI

Clinical Trials for Carafate

Image of UPMC Hillman Cancer Center in Pittsburgh, United States.

Mobile App for Cancer

18+
All Sexes
Pittsburgh, PA
The goal of this study is to determine whether a mobile application that combines real-time sensor data and patient-reported symptoms to trigger care-team contact recommendations is feasible and beneficial for patients receiving chemotherapy. The main questions it aims to answer are: * Is the mobile application feasible and acceptable to patients? * Do the alerts and guidance improve symptom management, quality of life, and engagement with the care team during treatment? Participants will: * Complete a demographic questionnaire at the beginning of the study and quality-of-life and health questionnaires at the beginning, midpoint, and end of study. * Complete daily symptom ratings via study application. * Wear a Fitbit activity tracker for 90 days. * At the end of the study, complete a semi-structured interview to provide feedback on the study. * Optional: At the beginning and end of the study, complete an in-person physical function assessment measuring balance (Short Physical Performance Battery).
Waitlist Available
Has No Placebo
UPMC Hillman Cancer CenterCarissa A Low
Image of University of California, Irvine - UCI Medical Center in Orange, United States.

Sling-Fiber Preservation vs. Conventional POEM for Achalasia

18+
All Sexes
Orange, CA
Peroral endoscopic myotomy (POEM) is an effective, minimally invasive treatment for achalasia, offering excellent rates of symptom relief. However, a significant drawback is the high incidence of gastroesophageal reflux disease (GERD) following the procedure. One proposed technical modification, the selective preservation of the sling fibers during gastric myotomy (SFP-POEM), may reduce this risk without compromising efficacy as compared to a conventional POEM procedure, which includes myotomy of the sling fibers. In this study, adults with achalasia will be randomly assigned to receive one of the two POEM technical approaches. Researchers will monitor whether preserving sling fibers reduces the rates of reflux esophagitis (classified as Los Angeles Grade B or higher) on follow-up endoscopy. Participants will be followed for up to 1 year after the procedure.
Waitlist Available
Has No Placebo
University of California, Irvine - UCI Medical CenterJason Samarasena, MD, MBA
Have you considered Carafate clinical trials? We made a collection of clinical trials featuring Carafate, we think they might fit your search criteria.Go to Trials
Image of Mayo Clinic in Rochester in Rochester, United States.

High Resolution Gastric Mapping and Gastroduodenal Manometry for Indigestion

18 - 80
All Sexes
Rochester, MN
Dyspepsia is a common problem attributed to gastric sensorimotor dysfunctions ie, delayed, or less frequently rapid gastric emptying (GE), impaired gastric accommodation, and increased gastric sensation. Therapeutic options manage symptoms, and there is no FDA approved medical therapy for dyspepsia. There is a need for better objective understanding of sensorimotor dysfunction in dyspepsia, as well as noninvasive, efficacious, safe, and inexpensive treatments for dyspepsia. The purpose of this research is to identify disturbances and characterize phenotypes in patients with functional dyspepsia, and to assess the correlations between symptoms (during the manometry and in daily life), gastric emptying, electrical activity (BSGM), and pressure activity (manometry).
Recruiting
Has No Placebo
Mayo Clinic in RochesterNicholas R Oblizajek, MD
Image of Medical College of Wisconsin in Milwaukee, United States.

Fosamprenavir + Sodium Alginate for GERD

18 - 64
All Sexes
Milwaukee, WI
The goal of this clinical trial is to learn if study drug Fosamprenavir-Sodium Alginate (FOS-SA) administered orally improves symptoms for Proton Pump Inhibitor (PPI)-refractory Gastro Esophageal Reflux Disease (GERD). The main questions it aims to answer are: 1. Does FOS-SA significantly improve heartburn severity over the 8-week treatment period 2. Does FOS-SA significantly improve regurgitation frequency over the 8-week treatment period 3. Does FOS-SA significantly improve symptoms of persistent GERD over the 8-week treatment period Researchers will compare FOS-SA to a placebo (a look-alike substance that contains no active drug) to see if FOS-SA works to treat PPI-refractory GERD. Participants will: 1. Take FOS-SA or placebo every day BID (twice a day) for 8 weeks 2. Visit the Adult Translational Research Unit (ATRU) seven times for consenting, screening, and checkups and tests 3. Keep a daily diary of their symptoms of persistent GERD
Phase 2
Waitlist Available
Medical College of WisconsinNikki Johnston, PhD.
Image of Brigham and Women's Hospital in Boston, United States.

Low Thermal Plasma for Marginal Ulcers

18+
All Sexes
Boston, MA
The objective of the study is to investigate the treatment of marginal ulcers with Low Thermal plasma in an endoscopic setting. By a treatment of the ulcerated areas with argon plasma with low power settings (\~ 1 W) we hypothesize that the size of the ulcers will shrink, and the healing is accelerated compared to standard of care alone. Patients will benefit from this minimally invasive approach compared to a much more invasive surgical approach that comes with higher risks and hospital stay length time. From a societal and scientific perspective, this study aims to extend the well-documented clinical benefits of plasma technology - from external wound healing to internal ulcer treatment - within an endoscopic framework. The success of this study could pave the way for broader applications of LTP in the treatment of other endoscopically accessible conditions such as peptic ulcers, duodenal ulcers and esophageal ulcers. This advancement has the potential not only to improve patient outcomes through less invasive methods, but also to position LTP as a cornerstone in the future of gastroenterological wound management strategies.
Recruiting
Has No Placebo
Brigham and Women's HospitalChristopher C. Thompson, MD, MSc
Have you considered Carafate clinical trials? We made a collection of clinical trials featuring Carafate, we think they might fit your search criteria.Go to Trials
Image of Cleveland Clinic Center for Abdominal Core Health in Cleveland, United States.

Mesh vs Pledgets for Hernia Repair

18+
All Sexes
Cleveland, OH
The goal of this clinical trial is to compare whether the use of Ovitex mesh provides superior reduction in 2-year recurrence compared to pledgeted suture closure (no mesh) for patients undergoing paraesophageal hernia repair at the Cleveland Clinic. The main questions it aims to answer are: * Determine whether there is a difference in 2-year rates of radiographic recurrence with Ovitex versus pledgeted sutures in paraesophageal hernia repair. * Assess patient quality of life (QOL) after paraesophageal hernia repair with pledgets and mesh. A two-tailed research hypothesis will be used to determine whether there are differences between the two arms
Recruiting
Has No Placebo
Cleveland Clinic Center for Abdominal Core HealthDavid M Krpata, MD
Have you considered Carafate clinical trials? We made a collection of clinical trials featuring Carafate, we think they might fit your search criteria.Go to Trials
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