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What is Dexilant Solutab
DexlansoprazoleThe Generic name of this drug
Treatment SummaryDexlansoprazole is a type of proton pump inhibitor (PPI) used to treat symptoms of gastroesophageal reflux disease (GERD) and erosion of the esophagus. Unlike other PPIs, dexlansoprazole is released in two phases at different pH values and times, providing two peak concentrations in the blood within 1-2 hours and 4-5 hours after dosing. This helps prevent breakthrough symptoms and the need for meal-associated dosing. Dexlansoprazole works by inhibiting the (H+, K+)-ATPase enzyme, which is involved in
Kapidexis the brand name
Dexilant Solutab Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Kapidex
Dexlansoprazole
2009
21
Approved as Treatment by the FDA
Dexlansoprazole, also called Kapidex, is approved by the FDA for 6 uses including Heartburn and healed erosive esophagitis .Heartburn
Helps manage Heartburn
healed erosive esophagitis
Helps manage healed erosive esophagitis
Symptomatic Non-erosive Gastroesophageal Reflux Disease
Heartburn
Helps manage Heartburn
Esophagitis
Helps manage healed erosive esophagitis
Erosive Esophagitis
Effectiveness
How Dexilant Solutab Affects PatientsDexlansoprazole is a type of drug that helps reduce acid production in the stomach. It works by blocking the enzyme that produces acid in the stomach (H+, K+)-ATPase, which can reduce symptoms of heartburn and other acid-related issues.
How Dexilant Solutab works in the bodyDexlansoprazole works by inhibiting the enzyme that helps control the amount of acid produced in the stomach. This enzyme, known as H/K ATPase, is activated when it comes into contact with an acidic environment. Dexlansoprazole binds to the SH groups of the enzyme and prevents it from transporting hydrogen ions into the stomach, which reduces the amount of acid produced. Dexlansoprazole also has a special delivery system that releases 25% of the drug dose in the upper part of the small intestine and 75% in the lower part. This helps reduce both basal and stimulated gastric acid production.
When to interrupt dosage
The dosage of Dexilant Solutab is subject to the revealed condition, such as healed erosive esophagitis, symptomatic non-erosive gastroesphageal reflux disease and Heartburn. The degree of dosage is contingent upon the administration technique (e.g. Capsule, delayed release or Tablet, orally disintegrating, delayed release) outlined in the table beneath.Condition
Dosage
Administration
Heartburn
, 30.0 mg, 60.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Nasogastric; Oral, Capsule, delayed release - Nasogastric; Oral
Erosive Esophagitis
, 30.0 mg, 60.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Nasogastric; Oral, Capsule, delayed release - Nasogastric; Oral
Esophagitis
, 30.0 mg, 60.0 mg
, Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Nasogastric; Oral, Capsule, delayed release - Nasogastric; Oral
Warnings
There are 20 known major drug interactions with Dexilant Solutab.Common Dexilant Solutab Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Dexlansoprazole.
Atazanavir
Major
Dexlansoprazole can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Dexlansoprazole.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Dexlansoprazole.
Infigratinib
Major
The serum concentration of Infigratinib can be decreased when it is combined with Dexlansoprazole.
Dexilant Solutab Toxicity & Overdose RiskThe highest dose of DEXILANT that is not toxic to mice, rats, and dogs is greater than 5,000 mg/kg. Common side effects include diarrhea, stomach pain, nausea, upper respiratory infection, vomiting, and gas. There have not been reports of serious overdose, but serious increases in blood pressure have been associated with taking twice daily doses of DEXILANT 60 mg. Animal studies have shown that long-term use of DEXILANT could cause cancer in rats. It is not expected to affect fertility or reproductive systems.
Dexilant Solutab Novel Uses: Which Conditions Have a Clinical Trial Featuring Dexilant Solutab?
Currently, seven studies are being conducted to assess the potential of Dexilant Solutab in treating Erosive Esophagitis, healed Erosive Esophagitis and symptomatic non-Erosive Gastroesophageal Reflux Disease.Condition
Clinical Trials
Trial Phases
Heartburn
1 Actively Recruiting
Phase 3
Erosive Esophagitis
3 Actively Recruiting
Phase 2, Phase 3
Esophagitis
0 Actively Recruiting
Dexilant Solutab Reviews: What are patients saying about Dexilant Solutab?
5Patient Review
3/21/2019 I took this medication for years, but then started to experience bad stomach pains and heart palpitations. I stopped taking it about a year ago and have been doing fine since. I sleep with my bed raised up and drink more water, and am careful of the foods I eat.
5Patient Review
4/24/2019 I was taking Tums nightly 4-5 times per week, and within three weeks of starting this medication, I haven't had a single instance of acid reflux!
5Patient Review
10/23/2018 This treatment has been a godsend for my Crohn's disease.
5Patient Review
11/3/2019 This medicine is awesome! Even though it's expensive, it works! I haven't experienced all of the side effects mentioned except for being very hungry at night. I'd rather experience that than the other symptoms I had before taking it. I had a really bad, chronic cough for months and nothing worked.
5Patient Review
3/21/2019 I took this medication for years, but then started having bad stomach pains and heart palpitations. I stopped taking it and have been off of it for about one year now. Sleep with my bed raised up and drink more water and I am more careful of the foods I eat--which has made all the difference.
Patient Q&A Section about dexilant solutab
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is DEXILANT being discontinued?
"is the last update for the Dexilant SoluTab brand name. If the FDA has approved generic versions of this product, there may be equivalent generic versions available."
Answered by AI
What is DEXILANT SoluTab?
"Dexilant SoluTab is a drug indicated for the treatment of heartburn associated with non-erosive gastroesophageal reflux disease, and for the maintenance of healed erosive esophagitis and relief of heartburn in adults 18 years and older."
Answered by AI
What is the best time of day to take DEXILANT?
"This medication is meant to be taken orally, as directed by a doctor. In most cases, it is taken once a day, with or without food. If your symptoms tend to occur after you eat, your doctor may tell you to take the medication before the same meal each day, in order to see the best results."
Answered by AI
What is DEXILANT used for?
"This medication is used to treat erosive esophagitis, which is a condition where the acid in the stomach washes back up into the esophagus, causing heartburn."
Answered by AI