Colcrys

Postcommissurotomy Syndrome, Pericarditis, Postpericardiotomy Syndrome + 4 more

Treatment

4 FDA approvals

2 Active Studies for Colcrys

What is Colcrys

Colchicine

The Generic name of this drug

Treatment Summary

Colchicine is a medication used to treat gout and Familial Mediterranean Fever (FMF). It was first approved by the FDA in 1961 and is derived from the Colchicum autumnale plant. Colchicine is commonly prescribed to reduce the swelling and pain caused by urate crystals in the joints associated with gout and may also help reduce inflammation in FMF.

Probenecid and Colchicine

is the brand name

image of different drug pills on a surface

Colcrys Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Probenecid and Colchicine

Colchicine

1982

59

Approved as Treatment by the FDA

Colchicine, commonly known as Probenecid and Colchicine, is approved by the FDA for 4 uses which include prophylaxis of Gout Flares and Gout Flares .

prophylaxis of Gout Flares

Gout Flares

Familial Mediterranean Fever (FMF )

Familial Mediterranean Fever

Effectiveness

How Colcrys Affects Patients

Colchicine helps to relieve the pain of gout and reduce flare-ups of Familial Mediterranean fever by interrupting the chemical processes that cause inflammation. It is important to be careful with this drug as a very small adjustment in the dose can make a big difference.

How Colcrys works in the body

We don't know the exact way colchicine works, but it likely stops inflammation by disrupting the inflammasome complex. This complex is involved in the production of an inflammatory messenger called interleukin-1. Colchicine also prevents neutrophils and other cells from adhering and producing a type of oxidative stress called superoxide. Lastly, it interferes with a type of NF-κΒ pathway that reduces inflammation. On a molecular level, colchicine is an anti-mitotic drug, meaning it stops cells from dividing by binding to tubulin and preventing microtubules from growing

When to interrupt dosage

The proposed dosage of Colcrys is contingent upon the diagnosed condition, including Gout Flares, Pericarditis and Postcommissurotomy Syndrome. The measure of dosage varies, contingent upon the technique of administration featured in the accompanying table.

Condition

Dosage

Administration

Familial Mediterranean Fever

0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg

, Tablet, Tablet - Oral, Oral, Tablet, film coated - Oral, Tablet, film coated, Capsule, Capsule - Oral, Ointment, Topical, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release

prophylaxis of Gout Flares

0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg

, Tablet, Tablet - Oral, Oral, Tablet, film coated - Oral, Tablet, film coated, Capsule, Capsule - Oral, Ointment, Topical, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release

Postcommissurotomy Syndrome

0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg

, Tablet, Tablet - Oral, Oral, Tablet, film coated - Oral, Tablet, film coated, Capsule, Capsule - Oral, Ointment, Topical, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release

Pericarditis

0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg

, Tablet, Tablet - Oral, Oral, Tablet, film coated - Oral, Tablet, film coated, Capsule, Capsule - Oral, Ointment, Topical, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release

Postpericardiotomy Syndrome

0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg

, Tablet, Tablet - Oral, Oral, Tablet, film coated - Oral, Tablet, film coated, Capsule, Capsule - Oral, Ointment, Topical, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release

Behcet Syndrome

0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg

, Tablet, Tablet - Oral, Oral, Tablet, film coated - Oral, Tablet, film coated, Capsule, Capsule - Oral, Ointment, Topical, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release

Gout Flares

0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg

, Tablet, Tablet - Oral, Oral, Tablet, film coated - Oral, Tablet, film coated, Capsule, Capsule - Oral, Ointment, Topical, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release

Warnings

Colcrys Contraindications

Condition

Risk Level

Notes

Liver Disease

Do Not Combine

Liver Disease

Do Not Combine

There are 20 known major drug interactions with Colcrys.

Common Colcrys Drug Interactions

Drug Name

Risk Level

Description

Choline C 11

Major

The therapeutic efficacy of Choline C 11 can be decreased when used in combination with Colchicine.

Eliglustat

Major

The metabolism of Eliglustat can be decreased when combined with Colchicine.

Fentanyl

Major

The metabolism of Fentanyl can be decreased when combined with Colchicine.

Aclidinium

Minor

Colchicine may decrease the excretion rate of Aclidinium which could result in a higher serum level.

Acrivastine

Minor

Colchicine may decrease the excretion rate of Acrivastine which could result in a higher serum level.

Colcrys Toxicity & Overdose Risk

Tests have found that the toxic dose of colchicine for mice is 5.87 mg/kg. In cases of colchicine overdose, people may experience abdominal pain, nausea, vomiting, diarrhea, and dehydration within 24 hours of ingesting the drug. Over the next 24-72 hours, serious complications such as multi-organ failure and respiratory depression may occur, which can lead to death. To treat an overdose, doctors may perform gastric lavage and provide supportive care, though there is no antidote for colchicine. It is important to keep this drug away from children. Dialysis is not an effective way

image of a doctor in a lab doing drug, clinical research

Colcrys Novel Uses: Which Conditions Have a Clinical Trial Featuring Colcrys?

Three active trials are assessing the potential of Colcrys as a prophylactic agent for Gout Flares, Behcet's Syndrome and Postpericardiotomy Syndrome.

Condition

Clinical Trials

Trial Phases

prophylaxis of Gout Flares

0 Actively Recruiting

Behcet Syndrome

0 Actively Recruiting

Gout Flares

1 Actively Recruiting

Phase 2

Pericarditis

1 Actively Recruiting

Phase 2, Phase 3

Familial Mediterranean Fever

0 Actively Recruiting

Postpericardiotomy Syndrome

0 Actively Recruiting

Postcommissurotomy Syndrome

0 Actively Recruiting

Colcrys Reviews: What are patients saying about Colcrys?

5

Patient Review

2/2/2015

Colcrys for Gout

I had severe gout pain in my left big toe and this treatment completely alleviated it. I just took three pills within one hour of each other and felt no pain afterwards. No side effects that I could tell, would definitely use again!

5

Patient Review

1/25/2019

Colcrys for Gout

Colcrys has been an integral part of my treatment plan and it really helps to manage active attacks in combination with indocin and allopurinol.

5

Patient Review

10/19/2014

Colcrys for Gout

4.3

Patient Review

11/30/2016

Colcrys for Gout

Colcrys is the only thing that works quickly, and it's not even that expensive if you use the coupon on their website.

4.3

Patient Review

4/20/2017

Colcrys for Familial Mediterranean Fever

This alleviated my kidney-related back pain after just a week of use. Additionally, it has helped to lessen the frequency and intensity of attacks.

4

Patient Review

9/21/2016

Colcrys for Gout

This drug effectively stopped my gout symptoms, but unfortunately caused some diarrhea in the process. I only need to take one pill per day now, and only if the gout tries to come back. Additionally, I stop taking my statin drug when taking colcrys.

3.7

Patient Review

5/16/2015

Colcrys for Inflammation of the Covering of the Heart or Pericardium

This medication works great, but my insurance company is giving me a hard time about it.

3.3

Patient Review

10/28/2015

Colcrys for Inflammation of the Covering of the Heart or Pericardium

While I experienced some great results from this treatment, like the disappearance of swelling and pain in various areas of my body, the weight loss came on too quickly for me to feel comfortable. In addition, the cost is prohibitively high.

3.3

Patient Review

9/9/2018

Colcrys for Familial Mediterranean Fever

I've been taking colchicine for over 30 years and it's really helped me. I'm outraged that my insurance won't cover the cost of the new Colcrys medication, which is 3 times as expensive. This needs to be changed!

3

Patient Review

9/7/2016

Colcrys for Gout

Worked great, but then I lost my prescription coverage. Now it costs $170 a month, which is really not affordable.

2

Patient Review

12/27/2014

Colcrys for Gout

1.7

Patient Review

5/17/2015

Colcrys for Familial Mediterranean Fever

The old generic version was very effective and only cost 10 cents per tablet. However, it could be a bit hard on the stomach for some people. The new version is much more expensive at $8 per tablet, which is outrageous.

1

Patient Review

11/22/2015

Colcrys for Inflammation of the Covering of the Heart or Pericardium

I was diagnosed with pericarditis 2 months after my open heart surgery. I was given this medication at the ER and my cardiologist want me to stay on it for 3 months. It's been 6 weeks. I don't have any side effects.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about colcrys

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of the drug Colcrys?

"If you experience any of the following symptoms, you should see a doctor immediately: black or tarry stools, blood in the urine or stools, burning, crawling, or tingling feeling in the skin, difficulty with breathing when exercising, fever with or without chills, large hive-like swellings on the face, eyelids, mouth, lips, or tongue, muscle weakness, or numbness in the fingers or toes."

Answered by AI

How quickly does Colcrys work?

"Colchicine helps reduce inflammation that can lead to symptoms, typically within 30 minutes to 2 hours. However, you may not notice a difference in inflammation or pain for a day or two. If you're taking colchicine to prevent flare-ups of familial Mediterranean fever, you may not feel any different."

Answered by AI

What does Colcrys do for gout?

"If you have too much uric acid in your blood, it can form crystals in your joints, which causes pain. Colchicine helps by reducing swelling and the amount of uric acid crystals."

Answered by AI

Clinical Trials for Colcrys