Ablation for Liver Cancer

Recruiting in Palo Alto (17 mi)

Overseen byConstantinos Sofocleous, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Memorial Sloan Kettering Cancer Center

No Placebo Group

Trial Summary

What is the purpose of this trial?

The purpose of this study is to see if the investigators can do some tests on tissue from the area of the ablation. The investigators want to know if a test can help predict whether the ablation worked. The treated tumor is normally evaluated with CT. The CT shows signs of treated tumor(s) in the area treated by ablation. However, cancer cells may begin to grow in or near the treated area. The CT scan cannot tell us if the cells are new cancer cells or if they are healthy liver cells that just look different because of the ablation. The test the investigators will study should be able to tell us the difference.

Research Team

Constantinos Sofocleous, MD

Principal Investigator

Memorial Sloan Kettering Cancer Center

Eligibility Criteria

This trial is for adults with liver tumors no larger than 5cm, who aren't surgical candidates or prefer not to have surgery. They should have a stable blood clotting measure (INR<1.5), enough platelets, and either confined liver disease or limited stable disease outside the liver.

Inclusion Criteria

Platelet count >= 50,000

I have been diagnosed with cancer that has spread to my liver.

My cancer is mainly in my liver or is stable and not widely spread.

See 3 more

Exclusion Criteria

I am under 18 years old.

My tumor is very close to a large blood vessel.

I have had more than 3 tumors treated without surgery.

See 4 more

Treatment Details

Interventions

CT guided percutaneous ablation (Procedure)

Trial OverviewThe study tests if analyzing tissue from ablated malignant liver metastases can predict treatment success. It involves CT-guided percutaneous ablation—a minimally invasive procedure—and examines whether new growths are cancerous post-treatment.

Participant Groups

1Treatment groups

Experimental Treatment

Group I: CT guided percutaneous ablationExperimental Treatment1 Intervention

The selected patients will undergo CT guided percutaneous ablation. The use of multi-tined electrode is encouraged, unless tumor location requires the use of an internally cooled needle electrode to eliminate injury to an adjacent vital structure or the operator prefers to use an internally cooled electrode for a specific reason.