Dapsone

Toxoplasmosis, prophylaxis of mild Toxoplasma gondii encephalitis, prophylaxis of moderate Toxoplasma gondii encephalitis + 14 more
Treatment
20 Active Studies for Dapsone

What is Dapsone

DapsoneThe Generic name of this drug
Treatment SummarySulfone is a type of antibiotic that is effective against a wide range of bacteria, but mainly used to treat Mycobacterium leprae. It works by stopping the bacteria from producing folic acid, which is necessary for growth. Sulfone is also used in combination with pyrimethamine to treat malaria.
Dapsoneis the brand name
image of different drug pills on a surface
Dapsone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Dapsone
Dapsone
1979
46

Effectiveness

How Dapsone Affects PatientsDapsone is a medication that has anti-inflammatory, antibacterial, and antibiotic properties. It is used to treat leprosy, malaria, and AIDS-related Pneumocystic carinii pneumonia. After taking it orally, it is quickly absorbed and spread throughout the body. It tends to remain in the skin, muscles, liver, and kidneys for up to three weeks after the treatment has stopped.
How Dapsone works in the bodyDapsone stops bacteria from multiplying by blocking the production of an important molecule. The way it works to reduce inflammation is unclear.

When to interrupt dosage

The suggested dosage of Dapsone is determined by the diagnosed condition, such as moderate Pneumocystis pneumonia, Relapsing Polychondritis and prophylaxis of mild Pneumocystis pneumonia. The dosage fluctuates based on the administration technique (e.g. Gel - Topical or Topical) demonstrated in the table underneath.
Condition
Dosage
Administration
Toxoplasmosis
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
prophylaxis of mild Toxoplasma gondii encephalitis
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Pneumonia, Pneumocystis
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Pneumonia, Pneumocystis
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
prophylaxis of moderate Pneumocystis pneumonia
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Bullous dermatitis herpetiformis
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
prophylaxis of mild Pneumocystis pneumonia
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Toxoplasmosis
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Acne Vulgaris
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Drug Resistance
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Pemphigus Vulgaris
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Relapsing Polychondritis
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Leprosy
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Bullous Systemic Lupus Erythematosus
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
prophylaxis of moderate Toxoplasma gondii encephalitis
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
Immune thrombocytopenic purpura
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral
HIV
, 0.05 mg/mg, 100.0 mg, 25.0 mg, 5.0 %, 0.075 mg/mg, 0.06 mg/mg, 0.085 mg/mg
Gel, Topical, , Gel - Topical, Oral, Tablet, Tablet - Oral

Warnings

There are 20 known major drug interactions with Dapsone.
Common Dapsone Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be increased when combined with Dapsone.
Acepromazine
Major
The risk or severity of QTc prolongation can be increased when Dapsone is combined with Acepromazine.
Aceprometazine
Major
The risk or severity of QTc prolongation can be increased when Dapsone is combined with Aceprometazine.
Acetophenazine
Major
The risk or severity of QTc prolongation can be increased when Dapsone is combined with Acetophenazine.
Alimemazine
Major
The risk or severity of QTc prolongation can be increased when Dapsone is combined with Alimemazine.
Dapsone Toxicity & Overdose RiskTaking too much of this drug may cause clogged sinuses, fainting, or hallucinations. If needed, measures should be taken to maintain normal blood pressure.
image of a doctor in a lab doing drug, clinical research

Dapsone Novel Uses: Which Conditions Have a Clinical Trial Featuring Dapsone?

144 active clinical trials are exploring the utility of Dapsone in alleviating Bullous Systemic Lupus Erythematosus, mild Pneumocystis pneumonia and Immune Thrombocytopenic Purpura.
Condition
Clinical Trials
Trial Phases
Pemphigus Vulgaris
2 Actively Recruiting
Phase 1
Pneumonia, Pneumocystis
0 Actively Recruiting
prophylaxis of mild Pneumocystis pneumonia
0 Actively Recruiting
Bullous dermatitis herpetiformis
0 Actively Recruiting
prophylaxis of moderate Pneumocystis pneumonia
0 Actively Recruiting
HIV
155 Actively Recruiting
Phase 2, Phase 1, Phase 3, Not Applicable, Phase 4, Early Phase 1
prophylaxis of moderate Toxoplasma gondii encephalitis
0 Actively Recruiting
prophylaxis of mild Toxoplasma gondii encephalitis
0 Actively Recruiting
Immune thrombocytopenic purpura
0 Actively Recruiting
Leprosy
0 Actively Recruiting
Pneumonia, Pneumocystis
0 Actively Recruiting
Bullous Systemic Lupus Erythematosus
0 Actively Recruiting
Toxoplasmosis
0 Actively Recruiting
Acne Vulgaris
2 Actively Recruiting
Phase 1, Phase 2, Early Phase 1
Toxoplasmosis
0 Actively Recruiting
Relapsing Polychondritis
1 Actively Recruiting
Phase 2
Drug Resistance
0 Actively Recruiting

Dapsone Reviews: What are patients saying about Dapsone?

5Patient Review
3/18/2014
Dapsone for PCP Prophylaxis
Dapsone has been a real life-saver for me. It's prevented PCP (a type of pneumonia) for the last three months, and I have no negative side effects to report.
5Patient Review
10/10/2015
Dapsone for Chronic Inflammatory Skin Disease Marked by Blisters
Dapsone has completely changed my life for the better. I was diagnosed with DH 24 years ago and have been taking half a 100mg tablet ever since then. It's great, but you can't take NSAIDs while on it because it'll make your symptoms 10 times worse.
5Patient Review
5/19/2013
Dapsone for Chronic Inflammatory Skin Disease Marked by Blisters
Dapsone has been a godsend for me. It's prevented my disease from flaring up and causing me pain, and as an added bonus, it keeps my skin clear!
5Patient Review
2/22/2016
Dapsone for Disease of the Skin Characterized by Pus-Filled Blisters
Dapsone has been a very effective treatment for me. I've been taking it for over 10 years now with great results.
3.7Patient Review
4/2/2017
Dapsone for Inflammation of Several Cartilages of the Body
I was on 100 mg twice a day. I ended up in the hospital with Methemoglobinemia, which is a rare side effect of Dapsone. Until that point, my pain and swelling were relatively controlled.
3.3Patient Review
11/12/2014
Dapsone for Chronic Inflammatory Skin Disease Marked by Blisters
Worked great for DH, but then my neutrophil count dropped and I had to stop using it due to the risk of infection. Now I'm stuck with an intense itch that won't go away. If anyone has any suggestions, please let me know!
3Patient Review
6/8/2018
Dapsone for Chronic Inflammatory Skin Disease Marked by Blisters
I unfortunately had a lot of side effects from this treatment, including stomach issues and muscle soreness. I only took three pills and felt like I was back on chemo. It's effective but not worth how sick it made me.
2Patient Review
12/1/2016
Dapsone for Disease of the Mouth and Eyes Marked by Blisters
Dapsone was prescribed to me for pemphigoid. It caused a reduction in red blood cells, anemia and yellowing of skin. I was reduced from one to 50mg, which made me tired and fatigued. Now I'm forgetful and anxious. The blisters have been reduced but never gone away. I didn't expect the mental effects. Worried because I have important job and am not old.
2Patient Review
1/1/2016
Dapsone for PCP Prophylaxis
I had a really tough time with shortness of breath while taking Dapsone. Once I stopped the drug at my doctor's recommendation, it still took over a week for things to get back to normal.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about dapsone

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of dapsone?

"stomach pain and nausea, vomiting, headache, dizzinessCan result in blurred vision, ringing in your ears, and sleep problems (insomnia)"

Answered by AI

Is dapsone good for acne?

"Aczone is a medication that can be used to treat acne on the face and body. It is particularly effective for inflammatory acne breakouts, but can also be somewhat effective for non-inflammatory breakouts like blackheads and milia."

Answered by AI

Is dapsone an immunosuppressant?

"Dapsone is a small molecule that has anti-inflammatory, immunosuppressive, antibacterial, and antibiotic properties. It is used clinically to treat leprosy and malaria, and is being investigated for the treatment of a variety of skin infections."

Answered by AI

What type of antibiotic is dapsone?

"Dapsone is a medication used to treat acne that is caused by bacteria. It is classified as a sulfone antibiotic and works by slowing or stopping the growth of bacteria and decreasing inflammation."

Answered by AI

Clinical Trials for Dapsone

Image of University of Alabama at Birmingham in Birmingham, United States.

Olfactory Training for HIV

18+
All Sexes
Birmingham, AL
The goal of this study is to examine two types of olfactory interventions (olfactory training vs overnight odor diffuser) in adults with HIV. The two research questions are: 1. Determine if participants find the intervention acceptable and assess feasibility of the study. 2. Determine if the intervention improves olfactory function and cognitive function. Participants will come to our office and be administered the baseline battery of questions including olfactory and cognitive performance tests. Then they will be randomized and sent home with one of the two interventions (below) in which they will engage in it for 8 weeks, after which they come back to our office for the posttest battery of questions including olfactory and cognitive performance test. 1. Olfactory Training at Home -- 4 scents in which they will smell twice a day for 8 weeks. 2. Overnight Diffuser Group -- a single scent diffuser that participants will turn on while they sleep and use for 8 weeks.
Phase < 1
Waitlist Available
University of Alabama at Birmingham
Image of Los Angeles General Medical Center in Los Angeles, United States.

Decision Support Tool for HIV Treatment

18+
All Sexes
Los Angeles, CA
This study is testing software designed to help healthcare providers choose the best HIV treatment combinations for their patients. HIV medicines, known as antiretroviral therapy (ART), can be complex to manage because the right regimen depends on many factors-such as drug resistance, other health conditions, and medication schedules. Many people with HIV are cared for by general clinicians who may not have access to HIV specialists, which can make treatment decisions more challenging. In this study, healthcare providers will use patient cases to compare standard HIV treatment resources with a new clinical decision support tool that gives evidence-based ART recommendations at the point of care. The investigators hypothesize that using the tool will help providers select treatment plans that better match clinical guidelines, make decisions faster, reduce mental effort, and increase overall satisfaction with the prescribing process.
Waitlist Available
Has No Placebo
Los Angeles General Medical CenterHayoun Lee, PhD
Image of University of North Carolina in Chapel Hill, United States.

MGD020 + MGD014 for HIV

18 - 65
All Sexes
Chapel Hill, NC
This research study aims to find out how safe and well tolerated the experimental study drugs are when given to persons with HIV (PWH) taking antiretroviral therapy (ART). The study treatments are MGD014 and MGD020, which are two antibodies developed specifically for HIV, and Vorinostat, an oral medication to help expose HIV in cells to the antibodies. The study will measure the impact of study treatment on non-active HIV in cells, and how long MGD014 and MGD020 stay in the body after they are given. In this study, participants will be randomly assigned to one of three groups. All participants receive MGD014 and MGD020, given sequentially as infusions through an IV for 4 doses. Participants in one group (group A) receive only MGD014 and MGD020. Participants in another group (group B) will stop taking their ART therapy for up to 8 weeks (a temporary treatment interruption (TTI)) while receiving MGD014 and MGD020. Participants in the third group (group C) receive Vorinostat in addition to MGD014 and MGD020. Total time of participation is about 8 months and involves 13 or 18 visits, depending on group assignment.
Phase 1
Recruiting
University of North CarolinaCynthia L. Gay, MD
Have you considered Dapsone clinical trials? We made a collection of clinical trials featuring Dapsone, we think they might fit your search criteria.Go to Trials
Have you considered Dapsone clinical trials? We made a collection of clinical trials featuring Dapsone, we think they might fit your search criteria.Go to Trials
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N-803 for HIV

18 - 70
All Sexes
San Francisco, CA
Even though HIV medicine stops the virus from making more copies of itself, the virus remains in the body by hiding inside of immune cells. This hidden virus is referred to as the "latent reservoir." Researchers on this team are studying whether stimulating the immune system can change the nature of the latent reservoir and if this could help people control HIV without the need to take regular HIV medicine. This study is testing a drug called N-803. N-803 is also known as Interleukin-15 or "IL-15", a powerful and long lasting protein that can affect the immune system by stimulating immune cells such as CD8+ T cells and natural killer (NK) cells. CD8+ T cells and NK cells are both crucial for eliminating infected cells. The drug is FDA-approved for the treatment of bladder cancer, but in this study the drug is being used experimentally for HIV.
Phase 2
Waitlist Available
UCSF
Image of Alabama CRS (Site ID: 31788) in Birmingham, United States.

Dasatinib + Quercetin for HIV

18+
All Sexes
Birmingham, AL
This clinical trial is a Phase II study designed to test the safety and effectiveness of a combination of dasatinib and quercetin (D+Q) in improving physical function for people with HIV who are frail or prefrail. The study will involve 80 participants, all aged 50 or older, who have been living with HIV for at least 10 years determined to meet criteria for diagnosis of frail or prefrail and are currently on a stable antiretroviral therapy with viral suppression. Participants will be randomly assigned to one of two groups: one group will receive the D+Q treatment, and the other will receive a placebo. The treatment will be given in six cycles over 12 weeks, with participants taking the medication for two days followed by 12 days without treatment. After the 12-week treatment period, participants will be monitored for another 12 weeks to assess the long-term effects. The study aims to determine if D+Q can improve physical function and other health outcomes in this population. Randomization will be stratified by sex and age to ensure balanced groups.
Phase 2
Waitlist Available
Alabama CRS (Site ID: 31788) (+26 Sites)
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DynamiCare + Patient Navigation for Stimulant Use Disorder

18+
All Sexes
New Haven, CT
Justice-involved individuals face disproportionately high rates of stimulant use disorder and HIV, along with disrupted access to HIV treatment and prevention services like ART and PrEP. Contingency management (CM) is the most effective intervention for stimulant use, but its use in justice-involved populations has been limited by logistical and structural barriers. DynamiCare is an FDA-approved mobile app that delivers behavioral CM and has shown promise in reducing stimulant use, but its impact on HIV-related outcomes remains unknown. The RESTORE study (Recovery and Engagement for Stimulant Users on Re-entry) will evaluate whether combining DynamiCare with patient navigation (DynamiCare-plus) improves PrEP/ART initiation and reduces stimulant use among individuals recently released from justice settings. The R61 phase will assess feasibility, acceptability, and preliminary effectiveness among 40 participants. If milestones are met, the R33 phase will scale to a randomized controlled trial with 252 participants to assess effectiveness, implementation, and cost. This scalable, mobile approach has the potential to address a critical gap in care for a highly vulnerable population.
Waitlist Available
Has No Placebo
Yale University (+1 Sites)Ank Nijhawan, MD
Have you considered Dapsone clinical trials? We made a collection of clinical trials featuring Dapsone, we think they might fit your search criteria.Go to Trials
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