Delestrogen

Low Testosterone, hypoestrogenism, Fracture + 25 more
Treatment
2 FDA approvals
20 Active Studies for Delestrogen

What is Delestrogen

Estradiol valerateThe Generic name of this drug
Treatment SummaryEstradiol Valerate (also known as E2V) is a medication that increases the amount of estrogen in the body. Estrogen is a hormone found naturally in the body and is the main female sex hormone. Estradiol Valerate is used to treat symptoms of menopause, such as hot flashes, vaginal dryness, mood changes, irregular menstrual cycles, chills, and sleeping problems. It is also used to treat hypoestrogenism due to hypogonadism, castration, or primary ovarian failure, and advanced androgen-dependent prostate cancer. Estradiol Valerate is available
Delestrogenis the brand name
image of different drug pills on a surface
Delestrogen Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Delestrogen
Estradiol valerate
1954
22

Approved as Treatment by the FDA

Estradiol valerate, also called Delestrogen, is approved by the FDA for 2 uses like Oral Contraceptives and Menorrhagia .
Oral Contraceptives
Used to treat Oral Contraceptives in combination with Dienogest
Menorrhagia
Used to treat Heavy Menstrual Bleeding in combination with Dienogest

Effectiveness

How Delestrogen Affects PatientsEstrogen has many effects throughout the body, and works by binding to two types of receptors: Estrogen Receptor Alpha (ERα) and Estrogen Receptor Beta (ERβ). It also binds to a G Protein-coupled Estrogen Receptor (GPER), which is important in the quick action of estrogen. Estrogen is found in many areas of the body, such as the breasts, uterus, ovaries, skin, prostate, bone, fat, and brain.
How Delestrogen works in the bodyEstradiol is a hormone found in the body, especially in women. When it enters cells, it binds to a receptor and enters the nucleus. It then interacts with genes and forms molecules that affect the cell. It can also increase the production of certain proteins in the body and lower levels of another hormone. All of this helps to reduce the symptoms of menopause, which are caused by a lack of estradiol.

When to interrupt dosage

The prescribed dosage of Delestrogen is contingent upon the diagnosed issue, including extreme menopausal vulvovaginal atrophy, Menopausal Symptoms and Menorrhagia. The amount of dosage fluctuates, in accordance with the administration procedure highlighted in the table below.
Condition
Dosage
Administration
Menopausal Symptoms
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Low Testosterone
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Fracture
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
severe menopausal vulvovaginal atrophy
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Ovarian Resection
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Irregular Menstruation
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Oral Contraceptives
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Uterus
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Pharmaceutical Preparations
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Malignant neoplasm of prostate
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
moderate menopausal vulvovaginal atrophy
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Ovarian Failure
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Primary Amenorrhoea
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Hot flashes
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
hypoestrogenism
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
moderate Menopausal Vasomotor Symptoms
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Hormone Replacement Therapy
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Premature Menopause
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Menstrual Irregularities
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet
Postmenopausal Osteoporosis
10.0 mg/mL, 20.0 mg/mL, 40.0 mg/mL, , 3.0 mg, 1.0 mg, 2.0 mg, 8.0 mg, 6.5 mg/mL
, Injection, Intramuscular, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Tablet - Oral, Liquid, Liquid - Intramuscular, Solution, Solution - Intramuscular, Kit, Oral, Tablet

Warnings

Delestrogen has eleven contraindications and should not be taken when encountering any of the circumstances indicated in the table below.Delestrogen Contraindications
Condition
Risk Level
Notes
Thromboembolism
Do Not Combine
history of deep venous thrombosis
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
Pulmonary Embolism
Do Not Combine
Pulmonary Embolism
Do Not Combine
Thromboembolism
Do Not Combine
Metrorrhagia
Do Not Combine
Breast Cancer
Do Not Combine
Breast
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Estradiol Valerate may interact with Pulse Frequency
There are 20 known major drug interactions with Delestrogen.
Common Delestrogen Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Estradiol valerate.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Estradiol valerate.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Estradiol valerate.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Estradiol valerate.
Anagrelide
Major
The metabolism of Anagrelide can be decreased when combined with Estradiol valerate.
image of a doctor in a lab doing drug, clinical research

Delestrogen Novel Uses: Which Conditions Have a Clinical Trial Featuring Delestrogen?

27 active trials are being conducted to investigate the potential of Delestrogen to address Irregular Menstruation, diminished reproductive organ function and female castration.
Condition
Clinical Trials
Trial Phases
Low Testosterone
14 Actively Recruiting
Phase 4, Phase 2, Phase 1, Not Applicable
Menopausal Symptoms
0 Actively Recruiting
hypoestrogenism
1 Actively Recruiting
Phase 4
Hormone Replacement Therapy
0 Actively Recruiting
Fracture
0 Actively Recruiting
Ovarian Failure
1 Actively Recruiting
Phase 1
Postmenopausal Osteoporosis
3 Actively Recruiting
Not Applicable, Phase 2
Menorrhagia
2 Actively Recruiting
Phase 4, Not Applicable
Irregular Menstruation
0 Actively Recruiting
Primary Amenorrhoea
0 Actively Recruiting
Ovarian Resection
0 Actively Recruiting
Menopause
0 Actively Recruiting
severe menopausal vulvovaginal atrophy
0 Actively Recruiting
Pharmaceutical Preparations
0 Actively Recruiting
female castration
0 Actively Recruiting
Uterus
0 Actively Recruiting
Malignant neoplasm of prostate
0 Actively Recruiting
Hot flashes
13 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Early Phase 1
Menstrual Irregularities
1 Actively Recruiting
Phase 4
Secondary Amenorrhea
0 Actively Recruiting

Delestrogen Reviews: What are patients saying about Delestrogen?

5Patient Review
7/30/2009
Delestrogen for Low Estrogen After Operation to Remove Ovaries
I've been using this medication for three months now and I really like it. It's easy to use, which is great for me because I have trouble remembering to take pills. I'm just waiting for my breasts to stop hurting and swelling. Does anyone know how long that will take?
5Patient Review
7/20/2011
Delestrogen for Low Estrogen After Operation to Remove Ovaries
Even though I get a bit of a rash after each injection, this treatment helps to supplement the hormones my body is lacking.
5Patient Review
4/9/2009
Delestrogen for Low Estrogen After Operation to Remove Ovaries
I'm intersex, and this medication does a lot for me.
5Patient Review
1/4/2009
Delestrogen for Low Estrogen After Operation to Remove Ovaries
I've been using this form of estrogen for two and a half months due to ovarian failure, and I definitely prefer it to taking pills or wearing a patch.
5Patient Review
11/13/2008
Delestrogen for Primary Ovarian Failure
This medication has completely alleviated my symptoms of hot flashes and dryness. Additionally, it's given me back my sexual desires after a total hysterectomy.
5Patient Review
11/13/2007
Delestrogen for Low Estrogen After Operation to Remove Ovaries
5Patient Review
3/5/2008
Delestrogen for Low Estrogen After Operation to Remove Ovaries
5Patient Review
3/27/2015
Delestrogen for Low Estrogen After Operation to Remove Ovaries
I had to have a full Hysterectomy when I was 31yrs old. Doctors tried me on Premarin pills but they gave me terrible Migraine headaches every day. The Doctor then switched me to the Delestrogen shots once a month. I have been on them for over 30yrs with no side effects. Now the Pharmacist in my town says you can't buy it anymore! What are you suppose to do when nothing else works. Why fix something that isn't broken??? I swear by this medicine..
1.7Patient Review
4/27/2011
Delestrogen for Low Estrogen After Operation to Remove Ovaries
The delestrogen I have been taking has made me happy in all ways.I have been very satisfied. I am a transgender while taken this I have seen my breasts enlarge along with the nipples and tenderness while using this drug. I would recommend it to all transgender people. I feel so much better about myself.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about delestrogen

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Delestrogen used for in men?

"Delestrogen is a medication used to treat a lack of estrogen. This can be caused by ovarian failure or a condition called hypogonadism. Some forms of estradiol injection are used in fertility treatment for women or men to treat the symptoms of prostate cancer."

Answered by AI

What is Delestrogen used for?

"This medication is a female hormone known as estrogen. It is used to help reduce symptoms of menopause such as hot flashes and vaginal dryness, which are caused by the body producing less estrogen."

Answered by AI

How does Delestrogen make you feel?

"Delestrogen may cause common side effects such as headaches, vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding, thinning scalp hair, or nausea, vomiting, bloating, stomach cramps."

Answered by AI

Clinical Trials for Delestrogen

Have you considered Delestrogen clinical trials? We made a collection of clinical trials featuring Delestrogen, we think they might fit your search criteria.
Have you considered Delestrogen clinical trials? We made a collection of clinical trials featuring Delestrogen, we think they might fit your search criteria.
Have you considered Delestrogen clinical trials? We made a collection of clinical trials featuring Delestrogen, we think they might fit your search criteria.
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