Enablex

Overactive Bladder Syndrome
Treatment
20 Active Studies for Enablex

What is Enablex

DarifenacinThe Generic name of this drug
Treatment SummaryDarifenacin (Enablex®, Novartis) is a drug used to treat urinary incontinence. It works by blocking certain receptors in the bladder muscle which can cause the urge to urinate. It should not be used in people with urinary retention. The clinical advantages of Darifenacin in treating overactive bladder syndrome are still unknown.
Enablexis the brand name
Enablex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Enablex
Darifenacin
2004
39

Effectiveness

How Enablex Affects PatientsDarifenacin is a drug that blocks certain muscles in the body, specifically the M3 receptor. In studies using humans, it has been shown to block M3 receptors more than other types of muscle receptors, and is mainly used to treat issues with the urinary bladder and salivary glands. Common side effects of this drug include dry mouth, constipation and abnormal vision.
How Enablex works in the bodyDarifenacin works by blocking the action of the M3 receptor. This receptor is responsible for things like contraction of the bladder, production of saliva, and movement of the iris.

When to interrupt dosage

The volume of Enablex is contingent upon the determined condition. The amount fluctuates as per the technique of delivery (e.g. Oral or Tablet, extended release) delineated in the table beneath.
Condition
Dosage
Administration
Overactive Bladder Syndrome
, 7.5 mg, 15.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral

Warnings

Enablex Contraindications
Condition
Risk Level
Notes
uncontrolled narrow-angle glaucoma
Do Not Combine
Urinary Retention
Do Not Combine
Gastric Retention
Do Not Combine
There are 20 known major drug interactions with Enablex.
Common Enablex Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Major
The risk or severity of adverse effects can be increased when Darifenacin is combined with Aclidinium.
Cimetropium
Major
The risk or severity of adverse effects can be increased when Darifenacin is combined with Cimetropium.
Eluxadoline
Major
The risk or severity of constipation can be increased when Darifenacin is combined with Eluxadoline.
Glycopyrronium
Major
The risk or severity of adverse effects can be increased when Darifenacin is combined with Glycopyrronium.
Ipratropium
Major
The risk or severity of adverse effects can be increased when Darifenacin is combined with Ipratropium.
Enablex Toxicity & Overdose RiskTaking too much of this drug can lead to serious side effects caused by blocking certain nerve signals in the brain.
image of a doctor in a lab doing drug, clinical research

Enablex Novel Uses: Which Conditions Have a Clinical Trial Featuring Enablex?

At present, there are 32 active studies assessing the potential of Enablex to effectively address Overactive Bladder Syndrome.
Condition
Clinical Trials
Trial Phases
Overactive Bladder Syndrome
29 Actively Recruiting
Phase 3, Not Applicable, Phase 4, Phase 1, Phase 2

Enablex Reviews: What are patients saying about Enablex?

5Patient Review
11/6/2012
Enablex for Needing to Urinate Immediately
This medication has been a total game-changer for me and my bladder control issues.
5Patient Review
9/24/2013
Enablex for Frequent Urination
I'm disappointed that my insurance company won't be covering this treatment next year. I switched to them for the same reason, and now I have to find a new option.
5Patient Review
11/13/2018
Enablex for Needing to Urinate Immediately
I'm glad my insurance company pushed me to try this cheaper alternative to Myrbetriq. Tolterodine didn't work for me, but Enablex did the trick with no noticeable side effects. My bladder control is great now and I don't have to worry about making a bathroom stop all the time.
5Patient Review
11/15/2012
Enablex for Needing to Urinate Immediately
I've been using Enablex for the past five months and it's really helped me. The dry mouth and constipation are manageable side effects that come with the territory, but the benefits have been worth it. I'm able to control my urges much better now and even walk to my office without having to go immediately. Taking it at night has also helped me sleep better.
5Patient Review
7/10/2014
Enablex for Urine Leakage When there is a Strong Desire to Void
No issues except for dry mouth. This completely solved my problem.
4Patient Review
10/13/2013
Enablex for Frequent Urination
I was on Vesicare for 18 months, but it wasn't effective enough. I started Enablex a few days ago and it's been working great in terms of frequency; however, now I'm experiencing really awful leg pains. I took some pain killers and will see if they help stabilize the situation. If not, I'll have to go back to Vesicare.
4Patient Review
2/4/2014
Enablex for Needing to Urinate Immediately
I was having sudden urges to urinate during the night time. I do not have them as frequently, but if I have coffee, wine or a lot to drink after 5 o'clock it is less effective.
4Patient Review
8/31/2013
Enablex for Frequent Urination
The only reason this isn't a five-star medication is because it can cause constipation.
4Patient Review
3/26/2016
Enablex for Overactive Bladder
I've been taking Enbrel for a little while now and I feel like it's not working as well as it used to.
3.3Patient Review
10/2/2013
Enablex for Urine Leakage When there is a Strong Desire to Void
Good stuff, but I need a higher dosage because I'm still waking up in the middle of the night.
3Patient Review
12/28/2013
Enablex for Urine Leakage When there is a Strong Desire to Void
I had a lot of negative side effects while taking this medication, including dry mouth and eyes, increased acid reflux, and decreased vision. I stopped taking it after just three months.
3Patient Review
1/30/2013
Enablex for Overactive Bladder
Enablex did help reduce my elderly father's urinary frequency and urgency, but the side effects were just too much for him to handle. He experienced constipation, nausea, appetite/weight loss, and mental confusion that made it difficult for him to remember even basic things. The medication helped with his original problem but not worth the cost of his physical and mental deterioration.
2Patient Review
9/18/2012
Enablex for Frequent Urination
The side effects were too much for me to handle, so I sought out alternative treatments. Thankfully, those worked well and I no longer have the same issues!
1Patient Review
9/10/2012
Enablex for Overactive Bladder
This medication gave me dry lips and mouth, an upset stomach, bowel problems, severe back pain, hot flashes, and more.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about enablex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who should not take Enablex?

"The maximum daily dose of Enablex should not exceed 7.5 mg for patients with moderate hepatic impairment as classified by the Child-Pugh scale."

Answered by AI

Does Enablex cause weight gain?

"Weight gain is a possible side effect of taking Enablex (darifenacin), but it does not happen very often. According to research, only 1% to 2% of people who take Enablex (darifenacin) end up gaining weight. To lower your risk of weight gain, make sure to stay active and eat healthy."

Answered by AI

What is the drug Enablex used for?

"This medication may help to reduce some urinary symptoms such as leakage, urgency, and frequency. It belongs to a class of drugs called antispasmodics."

Answered by AI

What are the side effects of taking darifenacin?

"The following are common symptoms of dehydration: dry mouth, constipation, upset stomach, stomach pain, diarrhea, weakness, and dry eyes."

Answered by AI

Clinical Trials for Enablex

Image of Stanford Medicine Department of Obstetrics & Gynecology in Palo Alto, United States.

Detrusor Nerve Radiofrequency Ablation for Overactive Bladder

22 - 80
Female
Palo Alto, CA
The goal of this clinical trial is to learn if a vaginal radiofrequency (RF) device called MORPHEUSV works to treat overactive bladder (OAB) in women. Researchers also want to learn how safe the device is for this indication. This study will include women ages 22 to 80 who have had OAB symptoms for at least 6 months. The main questions it aims to answer are: Does the MORPHEUSV device lower the number of daily episodes of accidental urine leakage caused by urgency? Does it work better than a sham (placebo) treatment? Researchers will compare the MORPHEUSV device to a sham treatment to see how well it reduces symptoms of overactive bladder. Participants will: 1) Receive one session of either the MORPHEUSV or sham treatment. 2) Track their symptoms using a diary and questionnaires 3) Return for three to six follow-up visits over 12 months. This study is being conducted at multiple clinics in the United States.
Waitlist Available
Device
Stanford Medicine Department of Obstetrics & Gynecology (+10 Sites)Mickey Karram, MDInMode MD Ltd.
Have you considered Enablex clinical trials? We made a collection of clinical trials featuring Enablex, we think they might fit your search criteria.Go to Trials
Have you considered Enablex clinical trials? We made a collection of clinical trials featuring Enablex, we think they might fit your search criteria.Go to Trials
Image of UConn Health in Farmington, United States.

MitoQ for Lower Urinary Tract Symptoms

50 - 75
Female
Farmington, CT
The goal of this clinical trial is to test the effect of a supplement called MitoQ (mitoquinol mesylate) on bladder symptoms such as urgency and frequency in women 50 years and older who have the metabolic syndrome. The main questions it aims to answer are: * Is the study design feasible and acceptable to participants? * Do participants taking the study drug get any improvement to their bladder symptoms compared to participants taking a placebo (a look-alike substance that contains no drug)? Participants will take 2 capsules of the study drug every morning for 4 months, answer many questions about their health including questions about their bladder health, perform physical and cognitive testing, give blood and urine samples, collect urine over 24 hour periods 3 times over the 4 months of the study, complete 3 day bladder diaries about how much they drink and void, undergo electrocardiograms, have their vitals and measurements (weight, height, waist circumference) taken, participate in 4 visits to the clinical research area and participate in many phone calls of varying length. Researchers will compare participants who were taking capsules containing MitoQ and participants taking capsules not containing MitoQ to see if MitoQ improves their bladder symptoms (urgency, frequency, nocturia, incontinence, etc.)
Phase 2
Recruiting
UConn HealthIman M Al-Naggar, PhD
Image of Mickey Karram MD in Corona Del Mar, United States.

Nerve Ablation for Overactive Bladder

21 - 80
Female
Corona Del Mar, CA
The goal of this Safety and efficacy of transvaginal Detrusor Nerve Ablation for treatment of overactive bladder symptoms, including refractory overactive bladder The main questions it aims to answer are: •Change from baseline to the end of treatment in a 3-day diary analysis to assess the reduction of urgency incontinence episodes. \[Time Frame: 3 months\] Subjects will undergo one treatment session and be reassessed at 4 weeks post-treatment. If less than a 50% improvement is noted, a second and third treatment session will be performed at 4-week intervals. If more than a 50% improvement is noted, patients will be followed longitudinally to assess the durability of the treatment. Investigators will have the ability to initiate a second and or third treatment on an individual basis. Follow-up will occur at 3- months, 6-months and 12 months after the subject's last treatment.
Waitlist Available
Has No Placebo
Mickey Karram MD (+2 Sites)Mickey Karram, MDInMode MD Ltd.
Image of University of Chicago in Chicago, United States.

Sacral Neuromodulation for Urge Incontinence

18+
Female
Chicago, IL
Sacral neuromodulation (SNM) was approved by the Food and Drug Administration (FDA) for the treatment of urgency incontinence (UUI) in 1998. One of two trial phase techniques are utilized prior to placement of the implantable pulse generator (IPG) to predict a patient's success with the device: a percutaneous nerve evaluation (PNE) or a stage implantation. Patients who experience a \> 50% improvement in UUI symptoms progress to permanent implantation. PNE offers significant advantages compared to a staged implantation including a single anesthetic and operating room trip. Historically, full implantation rates are only 40-50% following PNE versus 70-90% in women who undergo a staged approach. The lower rate of progression to full implantation after PNE may be attributed to lead migration. Newer data suggest up to 90% of PNE trials lead to full implantation. The investigators hypothesize that shortening PNE trial time to 3 days from 7 days will not result in a lower proportion of PNE trials leading to SNM implantation and may offer less time for lead migration. The investigators aim to perform a multi-center, randomized trial to determine if a 3-day PNE trial is not inferior to a 7-day PNE trial with respect to rates of progression to SNM implantation.
Recruiting
Has No Placebo
University of ChicagoKimberly Kenton, MD
Have you considered Enablex clinical trials? We made a collection of clinical trials featuring Enablex, we think they might fit your search criteria.Go to Trials
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Terms of Service·Privacy Policy·Cookies·Security