Tenoretic 100

Slow Heart Rate, Atrial Fibrillation, Migraine + 14 more

Treatment

7 FDA approvals

20 Active Studies for Tenoretic 100

What is Tenoretic 100

Atenolol

The Generic name of this drug

Treatment Summary

Atenolol is a type of medication called a beta-blocker. It was developed in the 1980s and is used to treat various cardiovascular conditions. Research has shown that it may not be as effective as other medications in preventing cardiovascular disease and mortality in patients with high blood pressure. Atenolol may be more beneficial for some patients than others, depending on their age and other factors.

Tenormin

is the brand name

image of different drug pills on a surface

Tenoretic 100 Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Tenormin

Atenolol

1990

432

Approved as Treatment by the FDA

Atenolol, otherwise called Tenormin, is approved by the FDA for 7 uses like Hypertensive disease and Refractory Hypertension .

Hypertensive disease

Used to treat Refractory Hypertension in combination with Chlorthalidone

Refractory Hypertension

Used to treat Refractory Hypertension in combination with Chlorthalidone

Hypertensive disease

Helps manage High Blood Pressure (Hypertension)

Slow Heart Rate

Heart Attack

Hemodynamically Stable

Hypertension

Effectiveness

How Tenoretic 100 Affects Patients

Atenolol is a type of drug used to slow down the heart rate, reduce electrical conductivity, and lower the amount of work that the heart needs to do. This helps reduce the mismatch between oxygen supply and demand and can provide relief from angina pectoris symptoms. It also helps control arrhythmic conditions like atrial fibrillation. Atenolol also helps lower blood pressure, though not as much as other types of beta-blockers, and it does not act on the blood vessels directly. Common side effects of atenolol include fatigue, depression, and sleep disturbances. It can also cause

How Tenoretic 100 works in the body

Atenolol is a type of drug called a beta-blocker. It binds to beta receptors in the body, particularly those in the heart, and blocks them from responding to normal signals. By blocking these signals, atenolol helps reduce the heart rate and increase the strength of each beat. It also relaxes the smooth muscles of the bronchial tubes, which can help with breathing. Atenolol works by inhibiting certain proteins that control heart rate, contraction strength, and other important processes in the body.

When to interrupt dosage

The suggested amount of Tenoretic 100 is contingent upon the determined condition, such as Atrial Fibrillation, Migraine and Hypertensive disease. The dosage fluctuates as per the technique of administration (e.g. Tablet - Oral or Tablet) featured in the table below.

Condition

Dosage

Administration

Slow Heart Rate

, 50.0 mg, 100.0 mg, 25.0 mg, 50.0 mg/mg, 5.0 mg/mg, 2.5 mg/mg, 0.5 mg/mL

Tablet, Oral, Tablet - Oral, , Injection, solution, Injection, solution - Intravenous, Intravenous, Buccal; Oral; Sublingual; Transmucosal, Tablet - Buccal; Oral; Sublingual; Transmucosal

Heart Attack

, 50.0 mg, 100.0 mg, 25.0 mg, 50.0 mg/mg, 5.0 mg/mg, 2.5 mg/mg, 0.5 mg/mL

Tablet, Oral, Tablet - Oral, , Injection, solution, Injection, solution - Intravenous, Intravenous, Buccal; Oral; Sublingual; Transmucosal, Tablet - Buccal; Oral; Sublingual; Transmucosal

Chest Pain

, 50.0 mg, 100.0 mg, 25.0 mg, 50.0 mg/mg, 5.0 mg/mg, 2.5 mg/mg, 0.5 mg/mL

Tablet, Oral, Tablet - Oral, , Injection, solution, Injection, solution - Intravenous, Intravenous, Buccal; Oral; Sublingual; Transmucosal, Tablet - Buccal; Oral; Sublingual; Transmucosal

Thyrotoxicosis

, 50.0 mg, 100.0 mg, 25.0 mg, 50.0 mg/mg, 5.0 mg/mg, 2.5 mg/mg, 0.5 mg/mL

Tablet, Oral, Tablet - Oral, , Injection, solution, Injection, solution - Intravenous, Intravenous, Buccal; Oral; Sublingual; Transmucosal, Tablet - Buccal; Oral; Sublingual; Transmucosal

Hypertension

, 50.0 mg, 100.0 mg, 25.0 mg, 50.0 mg/mg, 5.0 mg/mg, 2.5 mg/mg, 0.5 mg/mL

Tablet, Oral, Tablet - Oral, , Injection, solution, Injection, solution - Intravenous, Intravenous, Buccal; Oral; Sublingual; Transmucosal, Tablet - Buccal; Oral; Sublingual; Transmucosal

Atrial Fibrillation

, 50.0 mg, 100.0 mg, 25.0 mg, 50.0 mg/mg, 5.0 mg/mg, 2.5 mg/mg, 0.5 mg/mL

Tablet, Oral, Tablet - Oral, , Injection, solution, Injection, solution - Intravenous, Intravenous, Buccal; Oral; Sublingual; Transmucosal, Tablet - Buccal; Oral; Sublingual; Transmucosal

Migraine

, 50.0 mg, 100.0 mg, 25.0 mg, 50.0 mg/mg, 5.0 mg/mg, 2.5 mg/mg, 0.5 mg/mL

Tablet, Oral, Tablet - Oral, , Injection, solution, Injection, solution - Intravenous, Intravenous, Buccal; Oral; Sublingual; Transmucosal, Tablet - Buccal; Oral; Sublingual; Transmucosal

Secondary prevention Myocardial infarction

, 50.0 mg, 100.0 mg, 25.0 mg, 50.0 mg/mg, 5.0 mg/mg, 2.5 mg/mg, 0.5 mg/mL

Tablet, Oral, Tablet - Oral, , Injection, solution, Injection, solution - Intravenous, Intravenous, Buccal; Oral; Sublingual; Transmucosal, Tablet - Buccal; Oral; Sublingual; Transmucosal

Migraine Disorders

, 50.0 mg, 100.0 mg, 25.0 mg, 50.0 mg/mg, 5.0 mg/mg, 2.5 mg/mg, 0.5 mg/mL

Tablet, Oral, Tablet - Oral, , Injection, solution, Injection, solution - Intravenous, Intravenous, Buccal; Oral; Sublingual; Transmucosal, Tablet - Buccal; Oral; Sublingual; Transmucosal

Congestive Heart Failure

, 50.0 mg, 100.0 mg, 25.0 mg, 50.0 mg/mg, 5.0 mg/mg, 2.5 mg/mg, 0.5 mg/mL

Tablet, Oral, Tablet - Oral, , Injection, solution, Injection, solution - Intravenous, Intravenous, Buccal; Oral; Sublingual; Transmucosal, Tablet - Buccal; Oral; Sublingual; Transmucosal

Syndrome

, 50.0 mg, 100.0 mg, 25.0 mg, 50.0 mg/mg, 5.0 mg/mg, 2.5 mg/mg, 0.5 mg/mL

Tablet, Oral, Tablet - Oral, , Injection, solution, Injection, solution - Intravenous, Intravenous, Buccal; Oral; Sublingual; Transmucosal, Tablet - Buccal; Oral; Sublingual; Transmucosal

Coronary Artery Disease

, 50.0 mg, 100.0 mg, 25.0 mg, 50.0 mg/mg, 5.0 mg/mg, 2.5 mg/mg, 0.5 mg/mL

Tablet, Oral, Tablet - Oral, , Injection, solution, Injection, solution - Intravenous, Intravenous, Buccal; Oral; Sublingual; Transmucosal, Tablet - Buccal; Oral; Sublingual; Transmucosal

Hypertensive disease

, 50.0 mg, 100.0 mg, 25.0 mg, 50.0 mg/mg, 5.0 mg/mg, 2.5 mg/mg, 0.5 mg/mL

Tablet, Oral, Tablet - Oral, , Injection, solution, Injection, solution - Intravenous, Intravenous, Buccal; Oral; Sublingual; Transmucosal, Tablet - Buccal; Oral; Sublingual; Transmucosal

Hypertensive disease

, 50.0 mg, 100.0 mg, 25.0 mg, 50.0 mg/mg, 5.0 mg/mg, 2.5 mg/mg, 0.5 mg/mL

Tablet, Oral, Tablet - Oral, , Injection, solution, Injection, solution - Intravenous, Intravenous, Buccal; Oral; Sublingual; Transmucosal, Tablet - Buccal; Oral; Sublingual; Transmucosal

Tachycardia, Ventricular

, 50.0 mg, 100.0 mg, 25.0 mg, 50.0 mg/mg, 5.0 mg/mg, 2.5 mg/mg, 0.5 mg/mL

Tablet, Oral, Tablet - Oral, , Injection, solution, Injection, solution - Intravenous, Intravenous, Buccal; Oral; Sublingual; Transmucosal, Tablet - Buccal; Oral; Sublingual; Transmucosal

Hemodynamically Stable

, 50.0 mg, 100.0 mg, 25.0 mg, 50.0 mg/mg, 5.0 mg/mg, 2.5 mg/mg, 0.5 mg/mL

Tablet, Oral, Tablet - Oral, , Injection, solution, Injection, solution - Intravenous, Intravenous, Buccal; Oral; Sublingual; Transmucosal, Tablet - Buccal; Oral; Sublingual; Transmucosal

Tachycardia, Ventricular

, 50.0 mg, 100.0 mg, 25.0 mg, 50.0 mg/mg, 5.0 mg/mg, 2.5 mg/mg, 0.5 mg/mL

Tablet, Oral, Tablet - Oral, , Injection, solution, Injection, solution - Intravenous, Intravenous, Buccal; Oral; Sublingual; Transmucosal, Tablet - Buccal; Oral; Sublingual; Transmucosal

Warnings

Tenoretic 100 has four contraindications and should not be employed with the conditions outlined in the table below.

Tenoretic 100 Contraindications

Condition

Risk Level

Notes

Heart Block

Do Not Combine

Shock, Cardiogenic

Do Not Combine

Sinus Bradycardia

Do Not Combine

Heart Failure

Do Not Combine

There are 20 known major drug interactions with Tenoretic 100.

Common Tenoretic 100 Drug Interactions

Drug Name

Risk Level

Description

4-Bromo-2,5-dimethoxyphenethylamine

Major

The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Atenolol.

4-Methoxyamphetamine

Major

The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Atenolol.

Abediterol

Major

The therapeutic efficacy of Abediterol can be decreased when used in combination with Atenolol.

Adrafinil

Major

The therapeutic efficacy of Adrafinil can be decreased when used in combination with Atenolol.

Agrostis gigantea pollen

Major

The risk of a hypersensitivity reaction to Agrostis gigantea pollen is increased when it is combined with Atenolol.

Tenoretic 100 Toxicity & Overdose Risk

The toxic dose of atenolol in mice is 2g/kg when taken orally, 57mg/kg when taken intravenously, 134mg/kg when injected intramuscularly, and 400mg/kg when injected subcutaneously. In rats, the toxic dose is 2g/kg orally and 77mg/kg intravenously. The toxic dose in rabbits is 50mg/kg intravenously. Studies in rats and mice at doses of 300mg/kg per day, which is 150 times the maximum recommended human dose for 18-24 months, did not show any signs of carcinogenicity. However,

image of a doctor in a lab doing drug, clinical research

Tenoretic 100 Novel Uses: Which Conditions Have a Clinical Trial Featuring Tenoretic 100?

626 active clinical trials are currently being conducted to ascertain the potential of Tenoretic 100 in improving Atrial Fibrillation, Coronary Artery Atherosclerosis and Ventricular Tachycardia.

Condition

Clinical Trials

Trial Phases

Atrial Fibrillation

95 Actively Recruiting

Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1

Congestive Heart Failure

187 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1

Thyrotoxicosis

0 Actively Recruiting

Migraine

50 Actively Recruiting

Phase 4, Not Applicable, Phase 1, Phase 3, Phase 2, Early Phase 1

Secondary prevention Myocardial infarction

0 Actively Recruiting

Coronary Artery Disease

1 Actively Recruiting

Not Applicable

Heart Attack

23 Actively Recruiting

Not Applicable, Phase 1, Phase 4, Phase 2, Early Phase 1, Phase 3

Syndrome

4 Actively Recruiting

Phase 2, Phase 3, Not Applicable

Migraine Disorders

1 Actively Recruiting

Phase 3

Tachycardia, Ventricular

0 Actively Recruiting

Hypertension

0 Actively Recruiting

Slow Heart Rate

2 Actively Recruiting

Not Applicable

Hemodynamically Stable

0 Actively Recruiting

Hypertensive disease

0 Actively Recruiting

Chest Pain

2 Actively Recruiting

Not Applicable, Phase 2, Phase 3

Tachycardia, Ventricular

0 Actively Recruiting

Hypertensive disease

28 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

Tenoretic 100 Reviews: What are patients saying about Tenoretic 100?

5

Patient Review

4/8/2012

Tenoretic 100 for High Blood Pressure

I found this medication effective at keeping my blood pressure low; however, it made me feel very sleepy and tired. I also had to urinate frequently.

4.7

Patient Review

6/9/2011

Tenoretic 100 for High Blood Pressure

Though it caused some pretty severe side effects like dry mouth and anxiety, this medication did lower my blood pressure from 150/100 to 130/90. It also helped remove the excess water weight I was carrying around in my face, legs, and ankles.

4.3

Patient Review

5/27/2009

Tenoretic 100 for High Blood Pressure

For two years, this was the only treatment that helped my high blood pressure. However, I developed diabetes and high uric acid levels, which may be due to the chlorthalidone.

4.3

Patient Review

2/13/2009

Tenoretic 100 for High Blood Pressure

This treatment effectively solved my high blood pressure problem, which was likely due to genetics.

4.3

Patient Review

1/30/2009

Tenoretic 100 for High Blood Pressure

I constantly felt disoriented, tired, and sick while taking this medication.

4

Patient Review

11/25/2013

Tenoretic 100 for High Blood Pressure

I still get dizzy sometimes when I stand up too quickly, but this treatment has otherwise been good.

3.7

Patient Review

7/2/2010

Tenoretic 100 for High Blood Pressure

Since using Tenoretic, I have had to urinate 60-80 times per day. This has also resulted in me chronic bed-wetting and needing 20-30 adult diapers each day.

3.7

Patient Review

8/31/2016

Tenoretic 100 for High Blood Pressure

I have experienced a number of adverse effects from this medication, including but not limited to rashes, itching, swelling, and vaginal bleeding. Additionally, it has made sitting and sleeping uncomfortable due to the pain it causes in my back. I would like to stop taking this medication as soon as possible.

3

Patient Review

2/24/2008

Tenoretic 100 for High Blood Pressure

2.3

Patient Review

1/18/2010

Tenoretic 100 for High Blood Pressure

I'm struggling with fatigue still, but this treatment has been good so far.

2.3

Patient Review

4/8/2010

Tenoretic 100 for High Blood Pressure

I've found it difficult to maintain a consistent blood pressure while taking this medication. My readings have varied widely, from 189/84 to 130/60.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about tenoretic 100

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the generic name for tenoretic?

"Atenolol and chlorthalidone are available as 50mg/25mg+ and 100mg/25mg tablets. Both tablet formulations are scored."

Answered by AI

Is tenoretic the same as atenolol?

"This slows down the heart rate and decreases the force of heart muscle contraction. Chlorthalidone is a thiazide "water pill" (diuretic) that helps prevent your body from absorbing too much salt and keeps your potassium levels from getting too low.

Tenoretic is a combination of Atenolol, a selective beta blocker, and Chlorthalidone, a thiazide diuretic. Atenolol works by blocking certain natural compounds that may bind to receptors on the heart, which slows down the heart rate and decreases the force of heart muscle contraction. Chlorthalidone helps prevent your body from absorbing too much salt and keeps your potassium levels from getting too low."

Answered by AI

What drug class is tenoretic?

"Tenoretic is a prescription medicine used to treat the symptoms of High blood pressure (Hypertension). Tenoretic may be used alone or with other medications. Tenoretic is a combination of two drugs, a thiazide diuretic (water pill) and a beta-blocker. Beta-blockers work by slowing down the heart and reducing the amount of blood it pumps out. Thiazide diuretics help reduce the amount of water in the body by increasing the amount of urine produced."

Answered by AI

What is tenoretic used for?

"Atenolol is a beta-blocker that works by relaxing blood vessels and reducing heart rate. Chlorthalidone is a "water pill" (diuretic) that causes you to make more urine, which helps your body get rid of extra salt and water.

This medication is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This product contains 2 medications: atenolol and chlorthalidone. Atenolol is a beta-blocker that works by relaxing blood vessels and reducing heart rate. Chlorthalidone is a "water pill" (diuretic) that causes you to make more urine, which helps your body get rid of extra salt and water."

Answered by AI

Clinical Trials for Tenoretic 100

Image of Inova Alexandria Hospital in Alexandria, United States.

Heparin Dosing for Blood Clots and Heart Conditions

18+
All Sexes
Alexandria, VA

The goal of this clinical trial study is to test whether a mathematical calculation, using the patient's gender, weight and kidney function, can better predict a patient's heparin goal dose than a flat number of units per patient weight can. Participants will have the first dose of heparin infusion calculated, after which if adjustments are needed, the Hospital's prebuilt table for results driven dosing for this purpose is used. The researchers will compare the time it takes for the participants to get to the desired goal using the patient's information for calculation versus patients in the past who received the medication using the flat rate. The hypothesis is that the patients with enhanced personal data, gender, weight and kidney function, included for the initial dose, will get to their goal lab value sooner and with less chance of delay or overshooting the goal. A quicker time to goal lab value is beneficial to patients in many ways, including earlier treatment of the clot or coronary issue that the patient is experiencing.

Phase 4
Waitlist Available

Inova Alexandria Hospital

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Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL

This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.

Waitlist Available
Has No Placebo

U Health (+1 Sites)

Ziad Zoghby, M.D., M.B.A.

Biobeat Technologies Ltd.

Image of Johns Hopkins Medicine in Baltimore, United States.

Embolization for Migraine

18 - 80
All Sexes
Baltimore, MD

This study is to test the safety and feasibility of a procedure called embolization of the middle meningeal arteries (MMA), using a product called Onyx. Embolization creates a plug in the arteries. MMA embolization with Onyx is not approved for use in patients with migraines, but is currently used in patients with subdural hematomas. The FDA is allowing the use of Onyx in this study. It is thought that by using Onyx to block the middle meningeal arteries, the amount of migraine-causing substances which are released into the brain's bloodstream will be reduced. The company that manufactures Onyx, Medtronic, is providing the supplies for this study. Participants will be in the study for about 8 months after enrolling, including 6 months of follow up after the procedure. The participants will be asked to complete a daily headache diary and continue the participant's regular migraine medications. Participants will also have several clinic visits and be asked to provide blood samples for research.

Waitlist Available
Has No Placebo

Johns Hopkins Medicine

Risheng Xu, MD, PhD

Medtronic

Have you considered Tenoretic 100 clinical trials?

We made a collection of clinical trials featuring Tenoretic 100, we think they might fit your search criteria.
Go to Trials

Have you considered Tenoretic 100 clinical trials?

We made a collection of clinical trials featuring Tenoretic 100, we think they might fit your search criteria.
Go to Trials