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What is Epidiolex
CannabidiolThe Generic name of this drug
Treatment SummaryCannabidiol (CBD) is a chemical found in the cannabis plant. It binds to certain receptors in the body and can be used to treat a range of medical conditions, including anxiety, pain, epilepsy, and inflammation. CBD is usually taken as a pill or oil and can be found in products with different amounts of THC, the chemical that causes the ‘high’ associated with marijuana. CBD is available in Canada as a product called Sativex, which is used to treat spasticity in patients with multiple sclerosis. In the U.S., CBD is available under the brand name Epidiolex and is
Epidiolexis the brand name
Epidiolex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Epidiolex
Cannabidiol
2018
2
Approved as Treatment by the FDA
Cannabidiol, also known as Epidiolex, is approved by the FDA for 4 uses such as Metastatic Cancer and Pain .Metastatic Cancer
Used to treat Cancer, Advanced in combination with Dronabinol
Pain
Used to treat Severe Pain in combination with Dronabinol
Multiple Sclerosis
Used to treat Multiple Sclerosis in combination with Dronabinol
Pain
Used to treat moderate Pain in combination with Dronabinol
Effectiveness
How Epidiolex Affects PatientsResearchers are still uncovering the full effects of THC and CBD, but we know CBD can have many different effects, such as relieving pain and reducing anxiety. This is because it interacts with multiple parts of the body, such as CB1 and CB2 receptors in the endocannabinoid system, serotonin receptors, and opioid receptors. CBD may also affect the uptake of certain chemicals in the brain and block certain calcium channels.
How Epidiolex works in the bodyCBD and THC work by binding to receptors in the body, particularly the brain and spinal cord. These receptors, called cannabinoid (CB) receptors, regulate many processes in the body such as pain, memory, appetite and mood. CBD is known to act as a "negative allosteric modulator" for the CB1 receptor. This means that it can affect the receptor without completely activating it, allowing it to help with pain and reduce anxiety without causing any psychomimetic effects.
When to interrupt dosage
The measure of Epidiolex is contingent upon the diagnosed illness, including Pain, Pain and Multiple Sclerosis. The dosage also fluctuates as per the mode of administration (e.g. Oil or Kit; Oil; Solution / drops) featured in the table below.Condition
Dosage
Administration
Tuberous Sclerosis
, 100.0 mg/mL, 8.33 mg/mL, 50.0 mg/mL, 16.7 mg/mL, 25.0 mg/mL, 33.33 mg/mL, 200.0 mg/mL, 30.0 mg/mL, 20.0 mg, 0.0015 mg/mg, 2.5 mg/pump actuation
, Spray - Buccal, Buccal, Spray, Solution, Solution - Oral, Oral, Sublingual, Oil, Oil - Sublingual, Oil - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Patch, Topical, Patch - Topical
Pain
, 100.0 mg/mL, 8.33 mg/mL, 50.0 mg/mL, 16.7 mg/mL, 25.0 mg/mL, 33.33 mg/mL, 200.0 mg/mL, 30.0 mg/mL, 20.0 mg, 0.0015 mg/mg, 2.5 mg/pump actuation
, Spray - Buccal, Buccal, Spray, Solution, Solution - Oral, Oral, Sublingual, Oil, Oil - Sublingual, Oil - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Patch, Topical, Patch - Topical
Pain
, 100.0 mg/mL, 8.33 mg/mL, 50.0 mg/mL, 16.7 mg/mL, 25.0 mg/mL, 33.33 mg/mL, 200.0 mg/mL, 30.0 mg/mL, 20.0 mg, 0.0015 mg/mg, 2.5 mg/pump actuation
, Spray - Buccal, Buccal, Spray, Solution, Solution - Oral, Oral, Sublingual, Oil, Oil - Sublingual, Oil - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Patch, Topical, Patch - Topical
Epilepsy
, 100.0 mg/mL, 8.33 mg/mL, 50.0 mg/mL, 16.7 mg/mL, 25.0 mg/mL, 33.33 mg/mL, 200.0 mg/mL, 30.0 mg/mL, 20.0 mg, 0.0015 mg/mg, 2.5 mg/pump actuation
, Spray - Buccal, Buccal, Spray, Solution, Solution - Oral, Oral, Sublingual, Oil, Oil - Sublingual, Oil - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Patch, Topical, Patch - Topical
Multiple Sclerosis
, 100.0 mg/mL, 8.33 mg/mL, 50.0 mg/mL, 16.7 mg/mL, 25.0 mg/mL, 33.33 mg/mL, 200.0 mg/mL, 30.0 mg/mL, 20.0 mg, 0.0015 mg/mg, 2.5 mg/pump actuation
, Spray - Buccal, Buccal, Spray, Solution, Solution - Oral, Oral, Sublingual, Oil, Oil - Sublingual, Oil - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Patch, Topical, Patch - Topical
Lennox Gastaut Syndrome
, 100.0 mg/mL, 8.33 mg/mL, 50.0 mg/mL, 16.7 mg/mL, 25.0 mg/mL, 33.33 mg/mL, 200.0 mg/mL, 30.0 mg/mL, 20.0 mg, 0.0015 mg/mg, 2.5 mg/pump actuation
, Spray - Buccal, Buccal, Spray, Solution, Solution - Oral, Oral, Sublingual, Oil, Oil - Sublingual, Oil - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Patch, Topical, Patch - Topical
Metastatic Cancer
, 100.0 mg/mL, 8.33 mg/mL, 50.0 mg/mL, 16.7 mg/mL, 25.0 mg/mL, 33.33 mg/mL, 200.0 mg/mL, 30.0 mg/mL, 20.0 mg, 0.0015 mg/mg, 2.5 mg/pump actuation
, Spray - Buccal, Buccal, Spray, Solution, Solution - Oral, Oral, Sublingual, Oil, Oil - Sublingual, Oil - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Patch, Topical, Patch - Topical
Epilepsies, Myoclonic
, 100.0 mg/mL, 8.33 mg/mL, 50.0 mg/mL, 16.7 mg/mL, 25.0 mg/mL, 33.33 mg/mL, 200.0 mg/mL, 30.0 mg/mL, 20.0 mg, 0.0015 mg/mg, 2.5 mg/pump actuation
, Spray - Buccal, Buccal, Spray, Solution, Solution - Oral, Oral, Sublingual, Oil, Oil - Sublingual, Oil - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Patch, Topical, Patch - Topical
Warnings
There are 20 known major drug interactions with Epidiolex.Common Epidiolex Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Cannabidiol.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Cannabidiol.
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Cannabidiol.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Cannabidiol.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Cannabidiol.
Epidiolex Novel Uses: Which Conditions Have a Clinical Trial Featuring Epidiolex?
282 active studies are currently in progress to assess the potential of Epidiolex in alleviating Pain, Pain-related Symptoms and Metastatic Cancer.Condition
Clinical Trials
Trial Phases
Lennox Gastaut Syndrome
2 Actively Recruiting
Phase 2, Phase 1
Epilepsy
17 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Early Phase 1
Tuberous Sclerosis
14 Actively Recruiting
Phase 3, Not Applicable, Phase 4, Phase 2, Phase 1
Pain
0 Actively Recruiting
Metastatic Cancer
78 Actively Recruiting
Phase 2, Phase 1, Not Applicable, Phase 3, Early Phase 1
Pain
0 Actively Recruiting
Epilepsies, Myoclonic
7 Actively Recruiting
Phase 3, Phase 2, Phase 4, Phase 1
Multiple Sclerosis
124 Actively Recruiting
Phase 3, Not Applicable, Phase 4, Phase 2, Phase 1, Early Phase 1
Epidiolex Reviews: What are patients saying about Epidiolex?
4.3Patient Review
1/18/2022 I've been struggling with seizures since 2020. I tried a lot of other medications before this one, and none of them worked well or had such terrible side effects. Epidiolex has really helped me get my seizures under control, and I didn't even see full results until after the 6 month mark.
3.7Patient Review
3/6/2022 Epidiolex has helped me by decreasing the number of absence seizures and clusters I experience. Additionally, it has a calming effect. However, there are some negative side effects to be aware of such as acute euphoric and delusional episodes which could pose dangers. It is unclear if Epidiolex is the direct cause of these issues or if they occur because of interactions with other medications.
Patient Q&A Section about epidiolex
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Epidiolex used for?
"The U.S. Food and Drug Administration today approved Epidiolex (cannabidiol) [CBD] oral solution for the treatment of seizures associated with two rare and severe forms of epilepsy. This medication is meant for patients two years of age and older who suffer from Lennox-Gastaut syndrome or Dravet syndrome."
Answered by AI
Is Epidiolex a CBD?
"The drug EPIDIOLEX is the first and only FDA approved prescription cannabidiol that is able to treat seizures in patients that are one year of age or older that are associated with Lennox-Gastaut syndrome, Dravet syndrome, or tuberous sclerosis complex."
Answered by AI
Is Epidiolex the same as CBD oil?
"Are Epidiolex and CBD the same thing? Epidiolex is the brand name for the pharmaceutical-grade cannabidiol oil product produced by Greenwich, whereas other CBD, “hemp,” and medical marijuana products available may not be as pure and may contain small amounts of THC."
Answered by AI
How does Epidiolex make you feel?
"If you experience any of the following effects for an extended period of time, you should consult your doctor or pharmacist. These effects include drowsiness, tiredness, difficulty sleeping, lack of energy, decreased appetite, weight loss, and diarrhea."
Answered by AI