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What is Xulane
NorelgestrominThe Generic name of this drug
Treatment SummaryNorelgestromin is a medication used to prevent pregnancy. It is the active hormone in the ORTHO EVRA patch, which is applied to the skin to release the medication over time.
Ortho Evrais the brand name
Xulane Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ortho Evra
Norelgestromin
2001
7
Effectiveness
How Xulane Affects PatientsNorelgestromin is used as a form of birth control and in menopausal hormonal therapy. To work properly, it needs to be applied to the skin or taken with ethinyl estradiol in the form of a vaginal ring. Norelgestromin works by stopping gonadotropins, which inhibits ovulation.
How Xulane works in the bodyNorelgestromin prevents pregnancy by blocking the conversion of hormones in the body that create estrogen. It also binds to both estrogen and progesterone receptors, which helps to stop follicular development, make the uterus less likely to accept an egg, thicken cervical mucus and slow sperm from swimming into the uterus.
When to interrupt dosage
The degree of Xulane is contingent upon the specified disorder. The amount of dosage is contingent upon the technique of administration detailed in the table below.Condition
Dosage
Administration
Polycystic Ovarian Syndrome
, 0.015 mg/hour, 6.0 mg, 6.0 mg/[USP'U], 0.06 mg/hour, 0.02 mg/hour
, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Patch, Patch - Transdermal
Transdermal contraception therapy
, 0.015 mg/hour, 6.0 mg, 6.0 mg/[USP'U], 0.06 mg/hour, 0.02 mg/hour
, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Patch, Patch - Transdermal
Warnings
Xulane has fourteen prohibitive contraindications, and it should not be taken for any of the conditions given in the following table.Xulane ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Hereditary Angioedema Type III
Do Not Combine
Liver Neoplasms
Do Not Combine
estrogen-sensitive cancer
Do Not Combine
Pulse Frequency
Do Not Combine
Hypersensitivity
Do Not Combine
Breast Cancer
Do Not Combine
Hypersensitivity
Do Not Combine
Venous Thrombosis
Do Not Combine
Pulse Frequency
Do Not Combine
Uterine hemorrhage
Do Not Combine
Non-alcoholic Fatty Liver Disease
Do Not Combine
high risk of arterial thrombotic disease
Do Not Combine
Liver diseases
Do Not Combine
Common Xulane Drug Interactions
Drug Name
Risk Level
Description
Tranexamic acid
Major
Norelgestromin may increase the thrombogenic activities of Tranexamic acid.
Acetohexamide
Minor
The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Norelgestromin.
Carbutamide
Minor
The therapeutic efficacy of Carbutamide can be decreased when used in combination with Norelgestromin.
Chlorpropamide
Minor
The therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Norelgestromin.
Flibanserin
Minor
The risk or severity of adverse effects can be increased when Norelgestromin is combined with Flibanserin.
Xulane Novel Uses: Which Conditions Have a Clinical Trial Featuring Xulane?
Nine investigations are currently being conducted to assess the potential of Xulane in providing Transdermal contraception therapy.Condition
Clinical Trials
Trial Phases
Polycystic Ovarian Syndrome
8 Actively Recruiting
Not Applicable, Early Phase 1, Phase 4, Phase 1
Transdermal contraception therapy
0 Actively Recruiting
Xulane Reviews: What are patients saying about Xulane?
5Patient Review
4/12/2021 I've been using this patch for a while now and I love it. The only issue I ever have is that, because I'm allergic to latex, I sometimes have to clean the area a bit more when I change the patch.
5Patient Review
6/27/2021 Xulane has been a great product for me for the past 10 years. After my insurance switched me to Zafemy, I realized just how inferior that product was. Xulane sticks on properly and doesn't slide off, even when I'm sweating from playing tennis. It's also never given me any side effects, which is amazing.
2.3Patient Review
4/10/2022 I was on Xulane for seven months and will never use it again. It made me nauseous at first, but that went away after a couple of months. However, the headaches started afterwards and were really bad. I also felt on edge all the time while taking this medication, and it made my skin break out in dark spots. In addition, it caused unwanted hair growth on my body and face. Finally, it made me gain a lot of weight—more than I did after having my baby! I had to stop taking it and switch to another pill. Now I feel so much better; even the mental fog has lifted
2.3Patient Review
7/18/2020 I felt great while taking this medication, but I eventually realized that it was the cause of my migraines. I also broke out in hives during the second week.
1.7Patient Review
6/21/2021 I was about to give up on the patch until I found Twirla. It sticks great and works. Apparently Twirla is the newest patch on the market and isn't available everywhere yet, but with how good it works, I'm sure it will be soon.
1Patient Review
6/6/2021 I had two strokes while taking this medication. I'm only 19 and was very healthy prior to starting on this birth control. Other women have died from using the patch, and I wish I had never started taking it.
1Patient Review
6/14/2021 I was really unhappy with this birth control. The packaging and patch changed, and I started having problems. Every time I would get into water, the patch would come off without me touching it at all. I would go through all 3 patches in a week and wouldn’t be able to get any until the next month. This is ridiculous.
Patient Q&A Section about xulane
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Do you gain weight on Xulane?
"Xulane can sometimes lead to weight gain, which may manifest in the form of increased breast size. Xulane can also cause your body to hold on to more fluid, making your breast tissue more swollen."
Answered by AI
Is Xulane a good birth control?
"It made me gain weight and I had a lot of mood swings. I will never use it again,” said one reviewer.
The average rating for Xulane from all 435 ratings is 5.7 out of 10. 42% of reviewers reported having a positive experience while using Xulane, while 32% reported having a negative experience. One reviewer said, "I don't like Xulane. It made me gain weight and I had a lot of mood swings. I will never use it again.""
Answered by AI
What are the side effects of Xulane?
"You may experience skin irritation, nausea, vomiting, headache, bloating, breast tenderness, or weight change at the application site. You may also experience vaginal bleeding between periods (spotting), especially during the first few months of use."
Answered by AI
What is the weight limit for Xulane patch?
"If your weight is over 198 lbs (90 kg), XULANE may not be as effective and you should speak to your healthcare provider about which method of birth control would be better for you."
Answered by AI