Kenalog In Orabase

Macular Edema, Stomatitis, Denture, Ophthalmia, Sympathetic + 113 more

Treatment

16 FDA approvals

20 Active Studies for Kenalog In Orabase

Treatment for

Macular Edema

What is Kenalog In Orabase

TriamcinoloneThe Generic name of this drug

Treatment SummaryTriamcinolone is a type of steroid medication used to treat inflammation from a variety of conditions, such as allergic rhinitis and multiple sclerosis. It can be taken as a one-time treatment for knee pain related to osteoarthritis or used topically for conditions that respond to corticosteroid treatments. There are several forms of triamcinolone, including triamcinolone hexacetonide, triamcinolone acetonide, and triamcinolone diacetate. The FDA approved triamcinolone in 1957, and in 2021 they approved a suspension of triamcin

Aristocortis the brand name

Kenalog In Orabase Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Aristocort

Triamcinolone

1961

532

Approved as Treatment by the FDA

Triamcinolone, also called Aristocort, is approved by the FDA for 16 uses which include Lichen Planus and Ganglia .

Lichen Planus

Helps manage Lichen Planus (LP)

Ganglia

Helps manage cystic tumour of the ganglia

Granuloma Annulare

Helps manage granuloma annulare lesions

Psoriasis

Helps manage Psoriatic plaque

Neurodermatitis

Helps manage Lichen simplex chronicus

Lupus Erythematosus, Discoid

Helps manage Discoid Lupus Erythematosus (DLE)

granuloma annulare lesions

Helps manage granuloma annulare lesions

cystic tumour of the ganglia

Helps manage cystic tumour of the ganglia

Lichen Planus (LP)

Helps manage Lichen Planus (LP)

Alopecia Areata (AA)

Helps manage Alopecia Areata (AA)

Psoriatic plaque

Helps manage Psoriatic plaque

Lichen simplex chronicus

Helps manage Lichen simplex chronicus

Keloids Scars

Helps manage Keloids Scars

Discoid Lupus Erythematosus (DLE)

Helps manage Discoid Lupus Erythematosus (DLE)

Necrobiosis Lipoidica

Helps manage Necrobiosis lipoidica diabeticorum

Alopecia Areata

Helps manage Alopecia Areata (AA)

Effectiveness

How Kenalog In Orabase Affects PatientsTriamcinolone is a type of steroid medicine used to reduce inflammation in various parts of the body. It should not be injected directly into the spine.

How Kenalog In Orabase works in the bodyTriamcinolone works as an anti-inflammatory to reduce swelling and redness. It does this by blocking the breakdown of lysosomal membranes of leukocytes, which prevents the formation of arachidonic acid. This stops the production of prostaglandins and leukotrienes, which are signals that cause dilation of blood vessels and increased permeability. Triamcinolone also limits the production of pro-inflammatory signals, such as interleukin-6, interleukin-8, and monocyte chemoattractant protein-1, by blocking nuclear factor kappa-

When to interrupt dosage

The amount of Kenalog In Orabase is contingent upon the determined condition, including Mycosis Fungoides (MF), Mycoses and Alopecia Areata (AA). The measure additionally differs as per the strategy of administration (e.g. Ointment or Injection, suspension - Intralesional; Parenteral) outlined in the accompanying table.

Condition

Dosage

Administration

Ganglia

, 40.0 mg/mL, 10.0 mg/mL, 0.055 mg, 0.001 mg/mg, 0.25 mg/mL, 1.0 mg/mL, 0.0005 mg/mg, 0.00025 mg/mg, 0.005 mg/mg, 5.0 mg/mL, 20.0 mg/mL, 0.000147 mg/mg, 0.5 mg/mL, 40.0 mg, 1.0 mg, 0.000025 mg/mg, 0.1 %, 0.025 %, 5.0 mg, 0.25 mg, 2.0 mg, 4.0 mg, 0.5 %, 15.0 mg/mL, 6.5 mg, 80.0 mg/mL, 0.075 mg, 200.0 mg/mL, 32.0 mg, 0.055 mg/dose, 0.5 mg, 0.2 mg/pump actuation, 0.1 mg/dose, 25.0 mg/mL, 0.055 mg/pump actuation, 2.0 mg/mL, 0.4 mg/mL

Injection, suspension - Intra-articular; Intramuscular, Injection, suspension, Intra-articular; Intramuscular, , Intra-articular; Intralesional, Injection, suspension - Intra-articular; Intralesional, Nasal, Spray, metered, Spray, metered - Nasal, Topical, Cream, Cream - Topical, Ointment, Ointment - Topical, Lotion, Lotion - Topical, Intralesional; Parenteral, Injection, suspension - Intralesional; Parenteral, Intra-articular; Parenteral, Injection, suspension - Intra-articular; Parenteral, Intra-articular; Intrabursal; Intradermal; Intralesional, Injection, suspension - Intra-articular; Intrabursal; Intradermal; Intralesional, Aerosol, spray, Aerosol, spray - Topical, Paste, Paste - Topical, Kit, Injection, suspension - Intramuscular, Intramuscular, Dental, Paste - Dental, Suspension, Suspension - Intra-articular; Intramuscular, Intra-articular; Intrabursal; Intradermal; Intrasynovial, Suspension - Intra-articular; Intrabursal; Intradermal; Intrasynovial, Intra-articular; Intrabursal; Intramuscular, Suspension - Intra-articular; Intrabursal; Intramuscular, Intralesional, Suspension - Intralesional, Aerosol, metered, Aerosol, metered - Nasal, Respiratory (inhalation), Aerosol, metered - Respiratory (inhalation), Intra-articular, Suspension - Intra-articular, Oral, Tablet, Tablet - Oral, Liquid, Intra-articular; Intramuscular; Intrasynovial, Liquid - Intra-articular; Intramuscular; Intrasynovial, Syrup - Oral, Syrup, Intra-articular; Intradermal; Intramuscular, Liquid - Intra-articular; Intradermal; Intramuscular, Suspension - Intramuscular, Intra-articular; Intradermal; Intralesional; Intramuscular, Suspension - Intra-articular; Intradermal; Intralesional; Intramuscular, Spray, suspension - Nasal, Injection, solution, Injection, solution - Intra-articular; Intramuscular, Epidural; Infiltration; Intra-articular; Intramuscular; Topical, Kit - Epidural; Infiltration; Intra-articular; Intramuscular; Topical, Ophthalmic, Injection, suspension - Ophthalmic, Intravitreal, Suspension - Intravitreal, Infiltration; Intra-articular; Intramuscular; Respiratory (inhalation); Topical, Kit - Infiltration; Intra-articular; Intramuscular; Respiratory (inhalation); Topical, Spray, Spray - Topical, Intra-articular; Intrasynovial; Periarticular, Suspension - Intra-articular; Intrasynovial; Periarticular, Kit - Intra-articular; Intramuscular, Suspension - Ophthalmic, Subcutaneous, Implant, Implant - Subcutaneous, Epidural; Infiltration; Intra-articular; Intramuscular, Kit - Epidural; Infiltration; Intra-articular; Intramuscular, Intra-articular; Intramuscular; Intravitreal, Injection, suspension - Intra-articular; Intramuscular; Intravitreal, Epidural; Intra-articular; Intramuscular; Topical, Kit - Epidural; Intra-articular; Intramuscular; Topical, Epidural; Infiltration; Intra-articular; Intralesional, Kit - Epidural; Infiltration; Intra-articular; Intralesional, Intra-articular; Intralesional; Intramuscular; Intrasynovial; Parenteral, Injection, suspension - Intra-articular; Intralesional; Intramuscular; Intrasynovial; Parenteral, Kit - Intra-articular, Paste, dentifrice, Paste, dentifrice - Dental, Kit - Infiltration; Soft tissue; Topical, Infiltration; Soft tissue; Topical, Ointment - Buccal, Buccal, Gel, Gel - Topical, Emulsion - Topical, Emulsion, Kit - Topical, Intra-articular; Intramuscular; Topical, Injection, suspension - Intra-articular, Infiltration; Intra-articular; Intramuscular; Topical, Kit - Infiltration; Intra-articular; Intramuscular; Topical

Sarcoidosis

Stomatitis, Aphthous

Pericarditis

Pruritus

Multiple Sclerosis

induction of Diuresis

Acne Vulgaris

Psoriasis

Hypercalcemia

Macular Edema

Inflammation

Serum Sickness

Stomatitis, Denture

Acne Vulgaris

Pemphigus

Anemia, Hemolytic, Autoimmune

Itching of the Anus

Hives

Adrenal Insufficiency

Warnings

Kenalog In Orabase has four contraindications. It should not be employed in cases when any of the conditions given in the following table are present.Kenalog In Orabase Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Triamcinolone may interact with Pulse Frequency

Mycoses

Do Not Combine

active periocular infections

Do Not Combine

Eye Infections

Do Not Combine

There are 20 known major drug interactions with Kenalog In Orabase.

Common Kenalog In Orabase Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Triamcinolone is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Triamcinolone is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Triamcinolone.

Abetimus

Major

The risk or severity of adverse effects can be increased when Triamcinolone is combined with Abetimus.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be increased when combined with Triamcinolone.

Kenalog In Orabase Toxicity & Overdose RiskThe lowest toxic dose of triamcinolone acetonide in rats is 13,100µg/kg and 132mg/kg in mice. The lowest toxic dose of triamcinolone acetonide taken orally in rats is 1451mg/kg and 2168mg/kg in mice, and 105mg/kg for mice taken intraperitoneally. Overdosing on triamcinolone acetonide may cause Cushing's syndrome, which can be treated with supportive therapy and a medication called mifepristone.

image of a doctor in a lab doing drug, clinical research

Kenalog In Orabase Novel Uses: Which Conditions Have a Clinical Trial Featuring Kenalog In Orabase?

1076 active investigations are being conducted to assess the potential of Kenalog In Orabase for alleviating symptoms of Lupus, Atopic Dermatitis and Brain Metastases.

Condition

Clinical Trials

Trial Phases

Pruritus

0 Actively Recruiting

Craniotomy

0 Actively Recruiting

Tinea

0 Actively Recruiting

Ankylosing Spondylitis

3 Actively Recruiting

Phase 3, Not Applicable

Inflammation

67 Actively Recruiting

Not Applicable, Early Phase 1, Phase 1, Phase 2, Phase 3, Phase 4

Gingivitis

7 Actively Recruiting

Not Applicable, Phase 2

Asthma

86 Actively Recruiting

Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 1, Phase 3

Erythema Multiforme

1 Actively Recruiting

Phase 2

Eczema

0 Actively Recruiting

Thrombocytopenia

0 Actively Recruiting

Psoriatic Arthritis

28 Actively Recruiting

Not Applicable, Phase 3, Phase 1, Phase 4, Phase 2

Rheumatoid Arthritis

54 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1

Crohn's Disease

41 Actively Recruiting

Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4

cutaneous candidiasis

0 Actively Recruiting

Trichinosis

0 Actively Recruiting

Wound Infection

0 Actively Recruiting

Congenital adrenal hyperplasia

6 Actively Recruiting

Phase 3, Phase 1, Phase 2, Not Applicable

Metastatic Brain Tumors

59 Actively Recruiting

Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4

Synovitis

1 Actively Recruiting

Phase 4

Crohn Disease

0 Actively Recruiting