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What is Absorica
IsotretinoinThe Generic name of this drug
Treatment SummaryIsotretinoin is a medication derived from vitamin A used to treat severe acne. It was most commonly sold under the brand name Accutane, but is now discontinued. The use of this drug is associated with major risks during pregnancy, so it is only available through a special program in the United States. Isotretinoin was first approved by the FDA in 1982.
Accutaneis the brand name
Absorica Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Accutane
Isotretinoin
1982
78
Effectiveness
How Absorica Affects PatientsThe way isotretinoin works in the body is not well understood.
How Absorica works in the bodyIsotretinoin is used to treat acne. It works by reducing the production of sebum, which clogs pores, and by killing bacteria that can cause acne. It also reduces the formation of comedones and makes the environment less hospitable for acne-causing bacteria. It may also increase the body's immune response and reduce inflammation. It does this by altering how cells progress through the cell cycle, how they differentiate, how they survive, and how they die. There is also evidence that isotretinoin interacts with a protein called FoxO1, which may explain some of its effects.
When to interrupt dosage
The advocated dose of Absorica is reliant upon the ascertained condition, including Acne conglobata, Acne Vulgaris and Pregnancy. The measure of dosage changes, in accordance with the method of delivery (e.g. Capsule - Oral or Capsule) specified in the table beneath.Condition
Dosage
Administration
Sezary Syndrome
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Acne Conglobata
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Rosacea
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Acne Vulgaris
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Neuroblastoma
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Mycosis Fungoides
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Acne Vulgaris
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Warnings
Absorica ContraindicationsCondition
Risk Level
Notes
Carcinoma, Basal Cell
Do Not Combine
Squamous cell carcinoma
Do Not Combine
history of squamous cell
Do Not Combine
family history of basal cell carcinoma
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Isotretinoin may interact with Pulse Frequency
Common Absorica Drug Interactions
Drug Name
Risk Level
Description
Clomocycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Clomocycline.
Demeclocycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Demeclocycline.
Doxycycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Doxycycline.
Eravacycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Eravacycline.
Metacycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Metacycline.
Absorica Toxicity & Overdose RiskOverdosing on isotretinoin may cause symptoms such as vomiting, facial flushing, cracked lips, stomach pain, headaches, dizziness, and poor coordination. The lowest dose to cause toxicity in children is 30mg/kg, 24mg/kg in men, and 56mg/kg in women. Animal studies have found that doses higher than the recommended clinical dose can lead to tumors, abnormal adrenal gland growth, and testicular shrinkage. There is no evidence that isotretinoin affects sperm production, but it is not known whether it is expressed in breast milk.
Absorica Novel Uses: Which Conditions Have a Clinical Trial Featuring Absorica?
65 active trials are presently examining the possibility of using Absorica to address Rosacea, Neuroblastoma (NB) and Acne conglobata.Condition
Clinical Trials
Trial Phases
Sezary Syndrome
12 Actively Recruiting
Phase 2, Phase 1
Rosacea
6 Actively Recruiting
Not Applicable, Early Phase 1, Phase 2
Mycosis Fungoides
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting
Acne Conglobata
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting
Neuroblastoma
0 Actively Recruiting
Absorica Reviews: What are patients saying about Absorica?
5Patient Review
6/3/2017 I had really severe acne that left scars, but after five months of using this medication, my skin has cleared up so much! I use a sunscreen now whenever I go outside since this treatment makes your skin more sensitive to the sun, but it's definitely worth it for the results.
4.7Patient Review
3/26/2013 I tried Amnesteem, a generic version of Accutane, for months with no success. My acne got worse; I had deep cysts and the bumps actually oozed! I'm a female over 50 and never even had rosacea issues until I hit my 40's. This last time it was awful and spread over most of my face. Even with makeup I didn't want to leave the house.
4.7Patient Review
10/15/2014 I've been using Absorica for two months now, and the only downside is that it's caused my lips and skin to dry out. I've also developed eczema; however, my acne has significantly decreased in both frequency and severity, which is a huge plus. My skin is much more sensitive to sunlight now, so sunscreen is definitely a must. All things considered, I'm fairly pleased with the results thus far.
4.3Patient Review
2/8/2021 I used to really hate the way I looked because of my acne. None of the creams, lotions, or antibiotics ever worked for me, so when I finally found something that did (Absorica), it was a total miracle. I've been in remission for about four years now and couldn't be happier!
1Patient Review
5/16/2017 I just started taking Absorbca today, and I'm already feeling pretty nervous about the potential side effects. My doctor brushed off my concerns, but I still can't help but worry.
1Patient Review
2/23/2017 My son's acne got unimaginably worse after starting to use this medication. We had to switch treatments and thankfully that cleared things up, but not before his self-esteem was completely shattered. He's now left with scars that will need professional help to fix.
Patient Q&A Section about absorica
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Absorica generic for Accutane?
"Isotretinoin is available in many other brand names. Absorbica is not interchangeable with Accutane, generic versions of Accutane called isotretinoin, or Absorica LD unless specifically approved by your doctor."
Answered by AI
What is Absorica used for?
"This medication is for people with severe cystic acne that hasn't responded to other treatments like benzoyl peroxide or clindamycin applied to the skin, or tetracycline or minocycline taken orally. It's in a class of drugs called retinoids."
Answered by AI
Is Accutane the same as Absorica?
"ABSORICA is more readily absorbed by the body when taken without food, as compared to generic forms of isotretinoin. When taken without food, generic isotretinoin medications offer 63% less absorption by the body as compared to ABSORICA."
Answered by AI
What are the side effects of Absorica?
"Mental health problems, such as depression, psychosis, or thoughts of suicide, can lead to fatigue, skin reactions, such as infections or rash, dry skin, bone or joint pain, eye inflammation, difficulty moving, or a dry nose that can lead to nosebleeds."
Answered by AI