White Button Mushroom Extract for Breast Cancer Risk Reduction

Palo Alto (17 mi)

Overseen byLisa D Yee

Age: 18+

Sex: Female

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: N/A

Recruiting

Sponsor: City of Hope Medical Center

No Placebo Group

Trial Summary

What is the purpose of this trial?This trial is testing if eating white button mushrooms every day can help improve health in obese postmenopausal women at high risk of breast cancer. The mushrooms might help by making immune cells work better and reducing long-term inflammation. Researchers hope this could lower the risk of breast cancer and improve overall health.

Eligibility Criteria

This trial is for postmenopausal women with a high BMI (>=30 kg/m^2), at increased risk of breast cancer due to factors like genetic mutations (BRCA1/2, p53), family history, or previous diagnoses of certain breast conditions. Participants must be over 21 years old, have had no recent mushroom supplements, and not be on hormone therapies or other treatments that could interfere.

Inclusion Criteria

I have a genetic mutation linked to breast cancer.

Two or more of my relatives have had breast cancer, with one being younger than 50.

I am postmenopausal.

I am a postmenopausal woman with a BMI of 30 or higher and at high risk for breast cancer.

I am fully active or restricted in physically strenuous activity but can do light work.

My risk of developing breast cancer is high based on the Gail Risk Assessment.

I had a biopsy showing early breast changes in the last 10 years.

I have a family member with breast cancer diagnosed before 60.

I can swallow pills.

Exclusion Criteria

I have a history of bleeding easily or am currently using blood thinners.

I do not have any serious illnesses or social situations that would stop me from following the study's requirements.

I haven't taken hormone-modifying meds like HRT, SERMs, AIs, or GnRH modifiers in the last 3 months.

I am currently receiving treatment for cancer.

I haven't taken any mushroom supplements in the last 3 months.

I regularly take full dose aspirin or NSAIDs.

I have not gone through menopause.

I am currently taking medication that suppresses my immune system.

Treatment Details

Researchers are testing the effects of white button mushroom extract on inflammation and immune function in obese postmenopausal women at high risk for breast cancer. The study involves taking the supplement and monitoring changes through questionnaires and blood tests to see if it might reduce body fat or cancer risk.

1Treatment groups

Experimental Treatment

Group I: Prevention (white button mushroom)Experimental Treatment2 Interventions

Participants receive white button mushroom PO daily for 3 months in the absence of disease progression or unacceptable toxicity.