Naprelan

Q: What is Naprelan used for?

<p>NAPRELAN® can be used to treat various forms of <a href="https://www.withpower.com/clinical-trials/arthritis">arthritis</a>, as well as tendonitis, bursitis, and acute <a href="https://www.withpower.com/clinical-trials/gout">gout</a>. Additionally, it can be used to relieve mild to moderate <a href="https://www.withpower.com/clinical-trials/pain">pain</a> and menstrual cramps.</p>

Toothache, Chronic Pain, Migraine + 24 more

Treatment

18 FDA approvals

20 Active Studies for Naprelan

Treatment for

Toothache

What is Naprelan

Naproxen

The Generic name of this drug

Treatment Summary

Naproxen is a pain reliever and anti-inflammatory medication that was first introduced in 1976 as a prescription drug and then approved for over-the-counter use in 1994. It can be used to treat acute pain, rheumatic diseases, and migraines. Naproxen is generally well tolerated and is often prescribed as the first treatment option for pain relief. It is available in immediate and delayed release forms, as well as in combination with other medications (sumatriptan and esomeprazole) to provide additional benefits.

Naprosyn

is the brand name

image of different drug pills on a surface

Naprelan Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Naprosyn

Naproxen

1976

1260

Approved as Treatment by the FDA

Naproxen, otherwise known as Naprosyn, is approved by the FDA for 18 uses including Juvenile arthritis and Juvenile Idiopathic Arthritis (JIA) .

Juvenile arthritis

Used to treat Juvenile Idiopathic Arthritis (JIA) in combination with Esomeprazole

Juvenile Idiopathic Arthritis (JIA)

Used to treat Juvenile Idiopathic Arthritis (JIA) in combination with Esomeprazole

Toothache

Osteoarthritis (OA)

Used to treat Osteoarthritis (OA) in combination with Esomeprazole

Migraine

Rheumatoid Arthritis

Used to treat Rheumatoid Arthritis in combination with Esomeprazole

articular inflammation

Used to treat articular inflammation in combination with Esomeprazole

Inflammation

Used to treat articular inflammation in combination with Esomeprazole

Back

Ankylosing Spondylitis

Used to treat Ankylosing Spondylitis (AS) in combination with Esomeprazole

Dysmenorrhea

Osteoarthritis

Used to treat Osteoarthritis (OA) in combination with Esomeprazole

Headache

Back pain

Ankylosing Spondylitis (AS)

Used to treat Ankylosing Spondylitis (AS) in combination with Esomeprazole

Menstrual Distress (Dysmenorrhea)

Fever

Acute Coryza

Used to treat Acute Migraine in combination with Sumatriptan

Effectiveness

How Naprelan Affects Patients

Naproxen is a type of painkiller that reduces inflammation and fever. It works by blocking a certain enzyme (cyclo-oxygenase) that helps produce a type of chemical (prostaglandin) that can cause pain and swelling. While naproxen can effectively reduce pain, it can also lead to an increase in blood pressure and an increased risk of upper gastrointestinal bleeding. Taking other medications such as corticosteroids or anticoagulants at the same time as naproxen can increase the risk of upper gastrointestinal bleeding, as well as having a history of gastrointestinal ulcers.

How Naprelan works in the body

Naproxen works by blocking two enzymes, COX-1 and COX-2. COX-1 is a normal enzyme found in the stomach lining, while COX-2 is an enzyme that produces prostaglandins involved in pain, fever, and inflammation. By blocking these enzymes, naproxen reduces prostaglandin production, which helps reduce pain, fever, and inflammation. However, it also blocks the COX-1 enzyme, which can cause side effects like gastrointestinal upset and kidney problems.

When to interrupt dosage

The prescribed measure of Naprelan is contingent upon the identified condition, including Menstrual Distress (Dysmenorrhea), Migraine and Toothache. The dosage fluctuates as per the mode of delivery (e.g. Tablet, extended release or Tablet, delayed release) detailed in the table beneath.

Condition

Dosage

Administration

Acute Coryza

125.0 mg/mL, , 220.0 mg, 200.0 mg, 550.0 mg, 275.0 mg, 500.0 mg, 750.0 mg, 375.0 mg, 250.0 mg, 5.0 mg/mg, 125.0 mg, 60.0 mg, 1000.0 mg, 2.2 mg/mg, 1.0 mg/mg, 210.0 mg, 105.0 mg, 50.0 mg/mL, 25.0 mg/mL

, Suspension, Oral, Suspension - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet - Oral, Tablet, Tablet, film coated - Oral, Tablet, film coated, Kit, Kit - Topical, Topical, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule - Oral, Capsule, Tablet, coated, Tablet, coated - Oral, Kit - Oral, Rectal, Suppository, Suppository - Rectal, Tablet, extended release, Tablet, extended release - Oral, Cream - Topical, Tablet, for suspension, Tablet, for suspension - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Oral; Topical, Kit - Oral; Topical

Inflammation

Collagen Diseases

Migraine

Sinusitis

Influenza

Bursitis

Fever

Arthritis, Juvenile

Dysmenorrhea

Spasm

Epilepsy, Post-Traumatic

Back

Primary Dysmenorrhoea

Tendinopathy

Arthritis, Gouty

Rheumatoid Arthritis

Hay Fever

Nasal Congestion

Warnings

Naprelan has four contraindications and should not be utilized when enduring the conditions in the following table.

Naprelan Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Naproxen may interact with Pulse Frequency

Coronary Artery Bypass Grafting

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Naproxen may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Naproxen may interact with Pulse Frequency

There are 20 known major drug interactions with Naprelan.

Common Naprelan Drug Interactions

Drug Name

Risk Level

Description

Amiodarone

Major

The metabolism of Amiodarone can be decreased when combined with Naproxen.

Brigatinib

Major

The metabolism of Brigatinib can be decreased when combined with Naproxen.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Naproxen.

Enasidenib

Major

The metabolism of Enasidenib can be decreased when combined with Naproxen.

Erlotinib

Major

The metabolism of Erlotinib can be decreased when combined with Naproxen.

Naprelan Toxicity & Overdose Risk

Naproxen is available without a prescription, but this increases the chances of an overdose. Generally, the effects of such an overdose are minor, including drowsiness, fatigue, stomach pain, and nausea and vomiting. No specific antidote exists for naproxen overdose, however the symptoms should disappear with proper care. Naproxen should not be taken by pregnant women during their third trimester as it may lead to the early closure of the fetus's ductus arteriosus.

Naprelan Novel Uses: Which Conditions Have a Clinical Trial Featuring Naprelan?

635 active trials are currently underway to investigate the potential of Naprelan to relieve Chronic Pain, Migraine and Juvenile Rheumatoid Arthritis.

Condition

Clinical Trials

Trial Phases

Influenza

29 Actively Recruiting

Not Applicable, Phase 4, Phase 2, Phase 1, Phase 3

Postoperative Pain

19 Actively Recruiting

Phase 4, Phase 2, Phase 1, Phase 3, Not Applicable

Chronic Pain

130 Actively Recruiting

Not Applicable, Phase 4, Phase 2, Phase 3, Early Phase 1, Phase 1

Inflammation

0 Actively Recruiting

Bursitis

0 Actively Recruiting

Tendinopathy

0 Actively Recruiting

Nasal Congestion

0 Actively Recruiting

Juvenile arthritis

8 Actively Recruiting

Phase 2, Not Applicable, Phase 3

Rheumatoid Arthritis

55 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1

Spasm

0 Actively Recruiting

Back

8 Actively Recruiting

Not Applicable, Phase 3, Early Phase 1, Phase 1

Fever

2 Actively Recruiting

Not Applicable, Phase 4

Collagen Diseases

0 Actively Recruiting

Osteoarthritis

0 Actively Recruiting

Migraine

13 Actively Recruiting

Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4

Arthritis, Juvenile

1 Actively Recruiting

Not Applicable

Migraine

51 Actively Recruiting

Phase 4, Not Applicable, Phase 1, Phase 3, Phase 2, Early Phase 1

Arthritis, Gouty

0 Actively Recruiting

Acute Coryza

0 Actively Recruiting

Epilepsy, Post-Traumatic

0 Actively Recruiting

Naprelan Reviews: What are patients saying about Naprelan?

Patient Review

4/29/2009

Naprelan for Pain

Patient Review

5/31/2009

Naprelan for Inflammation of the Tendon

Patient Review

6/11/2009

Naprelan for Rheumatoid Arthritis

Patient Review

7/5/2011

Naprelan for Pain

One unfortunate side effect is hair loss.

Patient Review

7/20/2012

Naprelan for Rheumatoid Arthritis

This medication really helped my arthritis. I didn't experience any negative side effects, and only having to take it once a day was great.

4.7

Patient Review

7/27/2011

Naprelan for Inflammation of the Tendon

I've had Lyme Disease for 18 years and, as I've gotten older, the joint and muscle pain has become unbearable at times. In 2009, I was prescribed opiates to help with the pain; however, they did not work well for me. This drug is a miracle pill in comparison and doesn't come with the same cardiovascular risks.

4.3

Patient Review

4/26/2010

Naprelan for Pain

This pain reliever has been much better for me than oxycoten. I only have to take it once a day, and it's completely effective at keeping the pain and swelling down from my surgery.

Patient Review

1/12/2010

Naprelan for Pain

Patient Review

4/21/2011

Naprelan for Rheumatoid Arthritis

More helpful than other over-the-counter options.

Patient Review

3/14/2013

Naprelan for Inflammation of the Sac Surrounding the Joint - Bursitis

This treatment has been helpful in managing my pain.

2.7

Patient Review

6/21/2011

Naprelan for Inflammation of the Sac Surrounding the Joint - Bursitis

While this medication did alleviate the pain I was experiencing, I unfortunately developed a painful rash with blisters. If you experience any similar side effects, make sure to see a doctor right away.

2.3

Patient Review

7/1/2011

Naprelan for Painful Periods

This treatment did not alleviate any of the pain I was experiencing from my concussion.

Patient Review

10/18/2010

Naprelan for Pain

I've been taking this medication for my bunion and it's worked great in terms of healing the physical issue. However, I'm now dealing with a range of uncomfortable side effects like heartburn, nausea, and skin soreness that make the whole experience less than ideal.

1.7

Patient Review

2/16/2009

Naprelan for Pain

Patient Review

10/22/2011

Naprelan for Pain

I was given this medication for my hip pain, but it has done nothing to alleviate the discomfort. It's basically worthless; I would have been better off eating an M&M.

Patient Q&A Section about naprelan

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Naprelan used for?

"NAPRELAN® can be used to treat various forms of arthritis, as well as tendonitis, bursitis, and acute gout. Additionally, it can be used to relieve mild to moderate pain and menstrual cramps."

Answered by AI

How strong of a painkiller is naproxen?

"The naproxen content in each of these varies. The regular naproxen tablets contain 250mg, 375mg, or 500mg of naproxen. The fast-absorbing naproxen sodium is available in 220mg OTC capsules and tablets, and 275mg and 550mg tablets prescribed by a doctor."

Answered by AI

Is Naprelan the same as naproxen?

"NAPRELAN (naproxen sodium) is a nonsteroidal anti-inflammatory drug. It is available in 375 mg, 500 mg, and 750 mg strengths for oral administration."

Answered by AI

How much does Naprelan cost?

"The cost of one hundred Naprelan oral tablets, extended release (375 mg (as sodium)) varies depending on the pharmacy, but is typically around $2,303 for cash paying customers who do not have insurance."

Answered by AI