← Back to Search

Resistance Training vs Immobilization for Muscle Changes

N/A

Recruiting

Research Sponsored by Queen's University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up -2, 0 (-4, 0, and 4 hours), and 10 days

Awards & highlights

No Placebo-Only Group

Summary

This trial discusses the importance of skeletal muscle in maintaining overall health and how it is influenced by factors like exercise, diet, and inactivity. The study aims to understand the mechanisms that control skeletal muscle size

Who is the study for?

This trial is for healthy individuals interested in how muscles change with exercise and rest. Participants should be willing to undergo resistance training and have one leg immobilized temporarily. Specific eligibility details are not provided, but typically, participants must meet certain health standards.

What is being tested?

The study looks at the effects of resistance exercise on muscle proteins compared to the effects of not using a muscle (immobilization). It aims to understand how muscles grow stronger with exercise and weaken when they're not used.

What are the potential side effects?

Since this trial involves common physical activities like exercising or resting a limb, side effects might include typical workout-related discomfort such as muscle soreness or stiffness from immobilization.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ -2, 0 (-4, 0, and 4 hours), and 10 days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~-2, 0 (-4, 0, and 4 hours), and 10 days

This trial's timeline: 3 weeks for screening, Varies for treatment, and -2, 0 (-4, 0, and 4 hours), and 10 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Changes in average rates of muscle synthesis

Dynamic proteomic profiling

Secondary study objectives

Muscle torque

Protein expression (phosphorylation and content) of novel and known targets implicated in protein translation and mitochondrial-related protein expression

Quadriceps skeletal muscle volume

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Resistance TrainingExperimental Treatment1 Intervention

Participants will undergo 4 sessions of unilateral resistance training over a 10 day period (the resistance training protocol will include 3 sets of 8-12 reps of leg press and leg extension). All participants will complete this protocol. On day 0, participants will be asked to undergo a bout of unilateral resistance exercise, and the investigators will assess the acute response to exercise + protein feeding (via EAA supplement).

Group II: ImmobilizationExperimental Treatment1 Intervention

Participants will undergo 10 days of unilateral immobilization whereby a leg will remain in 60 degrees of flexion with the use of a brace. All participants will complete this protocol.

Do I qualify?Apply below to find out