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Resistance Training vs Immobilization for Muscle Changes
N/A
Recruiting
Research Sponsored by Queen's University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up -2, 0 (-4, 0, and 4 hours), and 10 days
Awards & highlights
No Placebo-Only Group
Summary
This trial discusses the importance of skeletal muscle in maintaining overall health and how it is influenced by factors like exercise, diet, and inactivity. The study aims to understand the mechanisms that control skeletal muscle size
Who is the study for?
This trial is for healthy individuals interested in how muscles change with exercise and rest. Participants should be willing to undergo resistance training and have one leg immobilized temporarily. Specific eligibility details are not provided, but typically, participants must meet certain health standards.
What is being tested?
The study looks at the effects of resistance exercise on muscle proteins compared to the effects of not using a muscle (immobilization). It aims to understand how muscles grow stronger with exercise and weaken when they're not used.
What are the potential side effects?
Since this trial involves common physical activities like exercising or resting a limb, side effects might include typical workout-related discomfort such as muscle soreness or stiffness from immobilization.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ -2, 0 (-4, 0, and 4 hours), and 10 days
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~-2, 0 (-4, 0, and 4 hours), and 10 days
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Changes in average rates of muscle synthesis
Dynamic proteomic profiling
Secondary study objectives
Muscle torque
Protein expression (phosphorylation and content) of novel and known targets implicated in protein translation and mitochondrial-related protein expression
Quadriceps skeletal muscle volume
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
2Treatment groups
Experimental Treatment
Group I: Resistance TrainingExperimental Treatment1 Intervention
Participants will undergo 4 sessions of unilateral resistance training over a 10 day period (the resistance training protocol will include 3 sets of 8-12 reps of leg press and leg extension). All participants will complete this protocol. On day 0, participants will be asked to undergo a bout of unilateral resistance exercise, and the investigators will assess the acute response to exercise + protein feeding (via EAA supplement).
Group II: ImmobilizationExperimental Treatment1 Intervention
Participants will undergo 10 days of unilateral immobilization whereby a leg will remain in 60 degrees of flexion with the use of a brace. All participants will complete this protocol.
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Who is running the clinical trial?
Queen's UniversityLead Sponsor
375 Previous Clinical Trials
124,978 Total Patients Enrolled