Nucynta Er

Pain, Acute Pain, Diabetic Neuralgia + 2 more

Treatment

6 Active Studies for Nucynta Er

What is Nucynta Er

Tapentadol

The Generic name of this drug

Treatment Summary

An opioid medication used to treat moderate to severe pain. This drug was approved by the FDA in 2008 and is used to help manage pain.

Nucynta

is the brand name

image of different drug pills on a surface

Nucynta Er Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Nucynta

Tapentadol

2009

46

Effectiveness

How Nucynta Er Affects Patients

Tapentadol is a synthetic painkiller that is 18 times weaker than morphine. It works by increasing the amount of a type of brain chemical (norepinephrine) and can be blocked by special antagonists like naloxone. Tapentadol does not affect the heart rate or rhythm.

How Nucynta Er works in the body

Tapendadol works by increasing the amount of the chemical norepinephrine in the body. It does this by binding to mu opioid receptors and blocking the reuptake of noradrenaline.

When to interrupt dosage

The suggested amount of Nucynta Er is contingent upon the identified condition, including intense, moderate Pain, Pain and Pain. The measure of dosage relies upon the method of administration (e.g. Tablet, extended release or Tablet, film coated, extended release - Oral) listed in the table beneath.

Condition

Dosage

Administration

Pain

100.0 mg, , 50.0 mg, 75.0 mg, 20.0 mg/mL, 150.0 mg, 200.0 mg, 250.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Solution - Oral, Solution, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release

Diabetic Neuralgia

100.0 mg, , 50.0 mg, 75.0 mg, 20.0 mg/mL, 150.0 mg, 200.0 mg, 250.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Solution - Oral, Solution, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release

Pain

100.0 mg, , 50.0 mg, 75.0 mg, 20.0 mg/mL, 150.0 mg, 200.0 mg, 250.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Solution - Oral, Solution, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release

Pain

100.0 mg, , 50.0 mg, 75.0 mg, 20.0 mg/mL, 150.0 mg, 200.0 mg, 250.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Solution - Oral, Solution, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release

Acute Pain

100.0 mg, , 50.0 mg, 75.0 mg, 20.0 mg/mL, 150.0 mg, 200.0 mg, 250.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Solution - Oral, Solution, Tablet, extended release, Tablet, extended release - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release

Warnings

Nucynta Er Contraindications

Condition

Risk Level

Notes

Asthma

Do Not Combine

Intestinal Pseudo-Obstruction

Do Not Combine

Hypercapnia

Do Not Combine

Pulse Frequency

Do Not Combine

Respiratory Function Impaired

Do Not Combine

Gastrointestinal obstruction

Do Not Combine

Mental Depression

Do Not Combine

There are 20 known major drug interactions with Nucynta Er.

Common Nucynta Er Drug Interactions

Drug Name

Risk Level

Description

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline

Major

The risk or severity of adverse effects can be increased when Tapentadol is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.

Azelastine

Major

Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Benmoxin

Major

The risk or severity of adverse effects can be increased when Tapentadol is combined with Benmoxin.

Brofaromine

Major

The risk or severity of adverse effects can be increased when Tapentadol is combined with Brofaromine.

Caroxazone

Major

The risk or severity of adverse effects can be increased when Tapentadol is combined with Caroxazone.

Nucynta Er Toxicity & Overdose Risk

Tests in rabbits, mice, and rats have shown the toxic dose of this drug to be 3200mg/kg, 300mg/kg, and 980mg/kg respectively. The most common side effects reported in patients taking this drug are dizziness, nausea, vomiting, drowsiness, and headaches.

image of a doctor in a lab doing drug, clinical research

Nucynta Er Novel Uses: Which Conditions Have a Clinical Trial Featuring Nucynta Er?

Presently, one clinical trial is assessing the viability of Nucynta Er in providing relief from acute, moderate Pain and Pain.

Condition

Clinical Trials

Trial Phases

Pain

0 Actively Recruiting

Acute Pain

0 Actively Recruiting

Pain

0 Actively Recruiting

Pain

0 Actively Recruiting

Diabetic Neuralgia

4 Actively Recruiting

Phase 1, Phase 2, Phase 3

Nucynta Er Reviews: What are patients saying about Nucynta Er?

5

Patient Review

6/29/2017

Nucynta Er for Chronic Pain

Cymbalta on its own didn't quite cut it for my fibromyalgia pain, but adding this medication to the mix finally allowed me to get relief and function normally again. I'm really thankful that I found this treatment; it's been a life-changer.

5

Patient Review

8/11/2017

Nucynta Er for Chronic Pain

I've been struggling with chronic pain for years now, and I've tried a lot of different medications. Nucynta ER is definitely the best in terms of providing relief without making me feel out of it. It's also easy on my stomach, which is a big plus since I have IBS.

5

Patient Review

11/1/2017

Nucynta Er for Chronic Pain

I have fibromyalgia and three cysts in my lower left sacrum. I had an operation to remove them, but the nerves were too close to the cysts so they may have caused a spinal fluid leak. They did a laminectomy, but there was no relief. I was on two 50 mg iron tabs and I would wake up every night in pain. Now I am on 100mg er and it really does work for 12 hours. I've been walking a lot since I started

5

Patient Review

8/11/2017

Nucynta Er for Chronic Pain

Nucynta ER has been the best pain medication I've tried in years. Not only does it relieve my chronic neck and back pain, but it doesn't make me feel high or fuzzy-headed. Additionally, it's easy on my stomach compared to other medications I've taken for my IBS.

5

Patient Review

11/1/2017

Nucynta Er for Chronic Pain

This treatment has been a godsend for me. I have fibromyalgia and three cysts in my lower left sacrum, which caused me a lot of pain. I had an operation to remove them, but it didn't provide any relief. I was taking two 50 mg iron tablets every night, but I would still wake up in pain. Now that I'm on the 100 mg extended release version, I don't have any pain at all and I can walk around without any problem.

5

Patient Review

6/29/2017

Nucynta Er for Chronic Pain

Cymbalta on its own did not provide me with enough pain relief to get through my day-to-day life. However, once I added this medication, I found that my pain was much more manageable and tolerable. This has been a huge help in being able to keep my job and maintain some semblance of a normal life.

4.3

Patient Review

8/11/2017

Nucynta Er for Chronic Pain

I have chronic pain from degenerative disk disease in my neck, right shoulder, right arm and hand. I used to take Oxycodone but hated the high feeling. Nucynta ER is much better for me.

4.3

Patient Review

8/11/2017

Nucynta Er for Chronic Pain

I suffer from chronic pain from degenerative disk disease in my neck, right shoulder, right arm and hand. I use to take Oxycodone but hated the high feeling. I've taken Nucynta ER

4

Patient Review

10/25/2016

Nucynta Er for Chronic Pain

Spinal Stenosis due to scar tissue from previous surgery at L5/S1. Worked better for my chronic pain at higher doses 200 to 300mg 2X/day. I been on it for just over a year, but a doctor recommended taking me off as it is still an opoid narcotic and not recommended for longer-term use (if a non-narcotic substitute can be helpful). Glad to have received the pain relief when I needed it most.

4

Patient Review

10/25/2016

Nucynta Er for Chronic Pain

Spinal Stenosis due to scar tissue from previous surgery at L5/S1. Worked better for my chronic pain at higher doses 200 to 300mg 2X/day. I been on it for just over a year, but a doctor recommended taking me off as it is still an opoid narcotic and not recommended for longer-term use (if a non-narcotic substitute can be helpful). Glad to have received the pain relief when I needed it most.

3.3

Patient Review

10/27/2022

Nucynta Er for Chronic Pain

I was in a car accident and Nucynta has helped with the pain, though I sweat terribly as a result. Has anyone else had this problem?

3.3

Patient Review

9/6/2016

Nucynta Er for Chronic Pain

I've just started taking this medication, but thus far I haven't experienced any negative side effects.

3.3

Patient Review

10/27/2022

Nucynta Er for Chronic Pain

Nucynta has been helpful for my pain management following a car accident, though I have experienced some extreme sweating as a side effect. If anyone has suggestions of other medications that might work better for me, please let me know.

3.3

Patient Review

9/6/2016

Nucynta Er for Chronic Pain

I've just started taking this medication, but thus far I haven't experienced any negative side effects.

2.7

Patient Review

1/2/2019

Nucynta Er for Chronic Pain

The 200mg slow release was difficult for me to break down, and I had to take it on an empty stomach to feel any pain relief. It also didn't last 12 hours like advertised; more like 10 hours.

2.7

Patient Review

1/2/2019

Nucynta Er for Chronic Pain

The 200mg slow release is hard to breakdown after they changed the composition, and I have to take it on an empty stomach to feel any pain relief. It doesn't last 12 hours; more like 10. And my digestion is really fragile and slow despite my healthy efforts.

1

Patient Review

6/28/2017

Nucynta Er for Severe Pain

Not only was this medication over-priced, but the pharmacy never had it in stock. This made it very difficult to get a hold of and ended up being quite frustrating. On top of that, it actually increased my foot pain rather than helping it.

1

Patient Review

5/5/2019

Nucynta Er for Chronic Pain

Despite being on 50mg of Nucynta for three days, I have yet to experience any pain relief from the nerve damage in my SI joints. From what I can tell, it looks like I'll need at least 100mg for this medication to be effective. This is my fifth attempt at finding a pain med that works, and so far nothing has been successful.

1

Patient Review

4/28/2018

Nucynta Er for Chronic Pain

I have chronic pain and have had two failed back surgeries. I'm currently herniated in my disc and need another surgery. This drug did not work for me at all and I experienced terrible withdrawal symptoms. My advice is to never take it.

1

Patient Review

6/28/2017

Nucynta Er for Severe Pain

Not only was this medication overpriced, but the pharmacy never had it in stock. It would take up to four days to get, and actually increased my foot pain. The drug has serotonin to help with depression which always had a negative effect on me. In short: I do not recommend this drug for chronic pain sufferers.

1

Patient Review

5/5/2019

Nucynta Er for Chronic Pain

So far, no luck with this medication in terms of pain relief for nerve damage in my SI joints. I may need to increase the dosage, but we'll see.

1

Patient Review

4/28/2018

Nucynta Er for Chronic Pain

I have chronic pain and have had two failed back surgeries. I'm currently herniated in my lower back and need another surgery. This drug hasn't been working for me as intended, so I'll be contacting the doctor soon. I've also had severe withdrawal from Duragesic Fentanyl patches. So all in all, I would advise against taking this medication.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about nucynta er

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long does it take for Nucynta ER to start working?

"When will I start to feel better?

You should notice some pain relief within 3-6 hours of taking extended release tapentadol. With continued twice daily dosing, a steady amount of drug will be present in the blood supply and help achieve continuous pain relief."

Answered by AI

What are the side effects of Nucynta ER?

"The following side effects may occur: nausea, vomiting, constipation, dizziness, drowsiness, dry mouth, increased sweating, or tiredness. To prevent constipation, eat dietary fiber, drink enough water, and exercise. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position."

Answered by AI

How often can you take nucynta ER?

"The recommended starting dose for patients who are not opioid tolerant is NUCYNTA ER 50 mg orally twice daily. Use of higher starting doses in patients who are not opioid tolerant can cause fatal respiratory depression."

Answered by AI

How does nucynta ER make you feel?

"Serious breathing problems may be more likely in older adults and in those who are debilitated or have wasting syndrome or chronic breathing disorders. Nucynta ER may cause common side effects including: constipation, nausea, vomiting, stomach pain; headache, feeling tired; or."

Answered by AI

Clinical Trials for Nucynta Er

Have you considered Nucynta Er clinical trials?

We made a collection of clinical trials featuring Nucynta Er, we think they might fit your search criteria.
Go to Trials
Image of Clinical Trials of Texas,LLC in Fredericksburg, United States.

YJ001 Spray for Diabetic Neuropathy

18 - 80
All Sexes
Fredericksburg, TX

This Phase I, randomized, double-blind and placebo controlled study is to evaluate the safety, tolerability, and PK, and to preliminarily assess the efficacy of topically administered YJ001 in a multiple-ascending dose (MAD) fashion in the patients with DPNP. The study will be conducted at a single study center. In this study, 2 cohorts (N=24, 12 subjects for each cohort), each cohort will consist of 10 active and 2 placebo, with approximately equal numbers of male and female subjects. Each subject will be administered a single dose of YJ001 as multiple sprays topically on both feet and below the ankle in the morning on Day 1 and Day 2, and will be administered as twice daily doses once in the morning and the other in the evening (with an interval of 11 to 13 h) from Day 3 through Day 11.

Phase 1
Recruiting

Clinical Trials of Texas,LLC

Douglas Scott Denham

Zhejiang Hanmai Pharmaceutical Technology Co., Ltd.