Hexadrol

Pemphigus, Macular Edema, Iridocyclitis + 102 more

Treatment

57 FDA approvals

20 Active Studies for Hexadrol

Treatment for

Pemphigus

What is Hexadrol

DexamethasoneThe Generic name of this drug

Treatment SummaryDexamethasone (MK-125) is a type of steroid that was developed in 1957 and approved by the FDA in 1958. It is used to treat a wide range of conditions, including endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and others. In 2020, a clinical trial recommended the use of dexamethasone for COVID-19 patients with severe respiratory symptoms, as it was found to reduce deaths by one third in those requiring ventilation and by one fifth in those requiring oxygen.

Decadronis the brand name

image of different drug pills on a surface

Hexadrol Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Decadron

Dexamethasone

1958

452

Approved as Treatment by the FDA

Dexamethasone, also known as Decadron, is approved by the FDA for 57 uses which include Seborrheic dermatitis and exfoliative erythroderma .

Seborrheic dermatitis

Helps manage Severe Seborrheic Dermatitis

exfoliative erythroderma

Helps manage exfoliative erythroderma

Erythroblastopenia

Helps manage Erythroblastopenia

Ankylosing Spondylitis

Helps manage Ankylosing Spondylitis (AS)

Choroiditis

Helps manage Choroiditis

Hay Fever

Helps manage Seasonal Allergic Rhinitis

Crohn Disease

Helps manage Regional Enteritis

Brain

Helps manage Edema of the cerebrum

Lymphoma, Non-Hodgkin

Helps manage Malignant Lymphomas

Bursitis

Helps manage Bursitis

Rhinitis, Allergic

Helps manage Perennial Allergic Rhinitis (PAR)

Inflammation

Multiple Myeloma

Used to treat Multiple Myeloma (MM) in combination with Isatuximab

Lupus

Helps manage Systemic Lupus Erythematosus (SLE)

Iridocyclitis

Helps manage Iridocyclitis

Berylliosis

Helps manage Berylliosis

Hypercalcemia

Helps manage Hypercalcemia

Trichinosis

Helps manage Trichinosis

Drug Allergy

Helps manage Drug hypersensitivity reaction

Adrenal Insufficiency

Helps manage Adrenal cortical hypofunctions

Ulcerative Colitis

Helps manage Ulcerative Colitis

Sarcoidosis

Helps manage Sarcoidosis

Synovitis

Helps manage Synovitis

Uveitis

Helps manage Uveitis

Acute Coryza

Helps manage acute rheumatic carditis

Mycosis Fungoides

Helps manage Mycosis Fungoides (MF)

Conjunctivitis

Helps manage anterior eye segment inflammation

Tennis Elbow

Helps manage Epicondylitis

Asthma

Helps manage Asthma

Arthritis, Gouty

Helps manage Acute Gouty Arthritis

Degenerative polyarthritis

Helps manage Posttraumatic Osteoarthritis

Adrenocortical Hyperfunction

Stevens-Johnson Syndrome

Helps manage Stevens-Johnson Syndrome

Cushing's Syndrome

Serum Sickness

Helps manage Serum Sickness

Anemia, Hemolytic

Helps manage acquired immune hemolytic anemia

Rheumatoid Arthritis

Helps manage Rheumatoid Arthritis

Optic Neuritis

Helps manage Optic Neuritis

Congenital adrenal hyperplasia

Helps manage Congenital Adrenal Hyperplasia (CAH)

Chorioretinitis

Helps manage Chorioretinitis

Ophthalmia, Sympathetic

Helps manage Ophthalmia, Sympathetic

Iritis

Helps manage Iritis

Pulmonary Eosinophilia

Helps manage Loeffler's syndrome

Aspiration Pneumonitis

Helps manage Aspiration Pneumonitis

Allergic Conjunctivitis (AC)

Helps manage Allergic Conjunctivitis (AC)

Anemia, Diamond-Blackfan

Helps manage Congenital Hypoplastic Anemia

Rheumatoid Arthritis, Juvenile

Helps manage Rheumatoid Arthritis, Juvenile

Acute Myeloid Leukemia (AML)

Helps manage Acute Leukemia (Category)

Tuberculosis

Helps manage Tuberculosis (TB)

varicella-zoster virus acute retinal necrosis

Helps manage varicella-zoster virus acute retinal necrosis

Rosacea

Helps manage Rosacea

Multiple Myeloma

Used to treat Trialled at least two prior therapies including lenalidomide and a proteasome inhibitor in combination with Isatuximab

Bullous dermatitis herpetiformis

Helps manage Bullous dermatitis herpetiformis

Thrombocytopenia

Helps manage Secondary thrombocytopenia

Pemphigus

Helps manage Pemphigus

Thyroiditis

Helps manage non-suppurative Thyroiditis

Psoriasis

Helps manage severe Psoriasis

Effectiveness

How Hexadrol Affects PatientsCorticosteroids are drugs that reduce inflammation by blocking certain signals from being sent to the body. The amount of time these drugs stay in the body depends on how they are taken. As the amount of corticosteroids people need to take is usually more than what their bodies naturally produce, they have a wide therapeutic window. It is important to warn people taking corticosteroids that they are at risk for their body's natural hormone system being suppressed and for getting infections more easily.

How Hexadrol works in the bodyCorticosteroids reduce inflammation in the body by decreasing the activity of certain proteins and genes. This helps to shrink blood vessels and reduce the number of white blood cells going to the site of inflammation. Low doses of corticosteroids work to reduce inflammation and high doses can suppress your immune system. Taking glucocorticoids over a long period of time can cause an increase in sodium levels and a decrease in potassium levels.

When to interrupt dosage

The measure of Hexadrol is based upon the diagnosed ailment, like Pink Eye, Brain and Keloids Scars. The degree of dosage also depends on the technique of delivery as detailed in the table below.

Condition

Dosage

Administration

Otitis

, 0.7 mg, 0.001 mg/mg, 10.0 mg/mL, 4.0 mg/mL, 1.5 mg, 1.0 mg/mL, 4.0 mg, 0.75 mg, 1.0 mg, 2.0 mg, 6.0 mg, 0.5 mg, 0.5 mg/mL, 0.1 %, 40.0 mg, 0.0005 mg/mg, 517.0 mg/mL, 0.0015 mg/mg, 0.4 mg, 20.0 mg, 0.1 mg/mL, 0.5 mg/units

, Implant, Implant - Intravitreal, Intravitreal, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Injection, solution - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Suspension / drops, Solution, Solution - Ophthalmic, Auricular (otic), Suspension - Auricular (otic), Intramuscular, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Injection, Intra-articular; Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Elixir, Elixir - Oral, Liquid, Liquid - Intramuscular; Intravenous, Intramuscular; Intrasynovial; Intravenous, Liquid - Intramuscular; Intrasynovial; Intravenous, Liquid - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Auricular (otic); Ophthalmic, Solution / drops - Auricular (otic); Ophthalmic, Solution - Intramuscular; Intrasynovial; Intravenous, Solution - Auricular (otic); Ophthalmic, Solution - Intra-articular; Intramuscular; Intravenous, Topical, Solution / drops - Topical, Ophthalmic; Topical, Liquid - Ophthalmic; Topical, Ointment - Topical, Liquid - Auricular (otic); Ophthalmic, Ointment - Auricular (otic); Ophthalmic, Solution - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Solution - Intramuscular; Intravenous, Liquid - Intra-articular; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Oral, Suspension / drops - Auricular (otic), Injection - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Dental, Liquid - Dental, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Epidural; Infiltration; Intramuscular; Intravenous, Injection - Intramuscular, Solution - Parenteral, Parenteral, Injection, solution - Ophthalmic, Intraocular, Injection, solution - Intraocular, Injection, suspension, Injection, suspension - Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, suspension - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Intramuscular; Intravenous; Topical, Kit - Intramuscular; Intravenous; Topical, Injection, emulsion, Injection, emulsion - Intramuscular; Intravenous, Insert, Insert - Ophthalmic, Solution - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Perineural, Suspension / drops - Topical

Open-angle glaucoma

Multiple Myeloma

Berylliosis

Chorioretinitis

Uveitis

Iridocyclitis

Scleritis

Choroiditis

Tennis Elbow

Congenital adrenal hyperplasia

Eye Infections

Adrenocortical Hyperfunction

Atopic Dermatitis

Trichinosis

cutaneous dermatophyte infection

Tuberculosis

Ankylosing Spondylitis

Keloids Scars

swelling of the eyes

Warnings

Hexadrol has nineteen contraindications, so it should be avoided for the conditions presented in the following table.Hexadrol Contraindications

Condition

Risk Level

Notes

active periocular infections

Do Not Combine

Eye

Do Not Combine

Tympanic membrane structure

Do Not Combine

suspected periocular infections

Do Not Combine

Eye Infections, Fungal

Do Not Combine

Viral Conjunctivitis

Do Not Combine

Communicable Diseases

Do Not Combine

Eye Infection

Do Not Combine

Mycoses

Do Not Combine

Chickenpox

Do Not Combine

External auditory canal structure

Do Not Combine

epithelial herpes simplex keratitis

Do Not Combine

External Ear

Do Not Combine

torn posterior lens

Do Not Combine

Open-angle glaucoma

Do Not Combine

Cornea

Do Not Combine

Eye Infections

Do Not Combine

ruptured posterior lens

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Dexamethasone may interact with Pulse Frequency

There are 20 known major drug interactions with Hexadrol.

Common Hexadrol Drug Interactions

Drug Name

Risk Level

Description

1,2-Benzodiazepine

Major

The metabolism of 1,2-Benzodiazepine can be increased when combined with Dexamethasone.

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Dexamethasone is combined with 2-Methoxyethanol.

3,5-diiodothyropropionic acid

Major

The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Dexamethasone.

6-O-benzylguanine

Major

The metabolism of 6-O-benzylguanine can be increased when combined with Dexamethasone.

7-ethyl-10-hydroxycamptothecin

Major

The metabolism of 7-ethyl-10-hydroxycamptothecin can be increased when combined with Dexamethasone.

Hexadrol Toxicity & Overdose RiskIn mice, the toxic dose of this drug taken orally is 6.5g/kg and intravenously is 794mg/kg. Taking too much of this drug over a long period of time can cause cataracts, glaucoma, high blood pressure, water retention, high cholesterol, ulcers, pancreatitis, muscle weakness, mood swings, psychosis, thinning of the skin, allergies, acne, increased body hair, reduced resistance to infections, facial swelling, high blood sugar, low calcium levels, low phosphorous levels, and slowed growth. If you think you’ve taken too much of this drug,

image of a doctor in a lab doing drug, clinical research

Hexadrol Novel Uses: Which Conditions Have a Clinical Trial Featuring Hexadrol?

345 active studies are currently underway to determine the potential of Hexadrol for handling Eye Infections, Stevens-Johnson Syndrome and Chorioretinitis.

Condition

Clinical Trials

Trial Phases

Diabetic Macular Edema

21 Actively Recruiting

Not Applicable, Phase 3, Phase 4, Phase 2, Phase 1

Rheumatoid Arthritis

59 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1

Arthritis, Gouty

0 Actively Recruiting

Asthma

104 Actively Recruiting

Phase 4, Not Applicable, Early Phase 1, Phase 2, Phase 3, Phase 1

Lupus

64 Actively Recruiting

Phase 2, Phase 1, Phase 3, Not Applicable, Phase 4

Acute Myeloid Leukemia (AML)

36 Actively Recruiting

Phase 1, Phase 2, Phase 3, Not Applicable

Tennis Elbow

0 Actively Recruiting

Otitis Externa

0 Actively Recruiting

Drug Allergy

0 Actively Recruiting

Inflammation

62 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3, Early Phase 1

Allergic Conjunctivitis (AC)

0 Actively Recruiting

cutaneous dermatophyte infection

0 Actively Recruiting

Alopecia Areata

0 Actively Recruiting

Communicable Diseases

0 Actively Recruiting

Neurodermatitis

0 Actively Recruiting

Pulmonary Eosinophilia

0 Actively Recruiting

Uveitis

6 Actively Recruiting

Phase 4, Not Applicable, Phase 2, Phase 3, Phase 1

Thyroiditis

0 Actively Recruiting

Hypercalcemia

2 Actively Recruiting

Phase 4, Not Applicable

Lupus Erythematosus, Discoid

2 Actively Recruiting

Phase 2

Patient Q&A Section about hexadrol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Dexamethasone Sodium Phosphate injection used for?

"Dexamethasone injection is a medication used to treat severe allergic reactions, edema, gastrointestinal disease, and certain types of arthritis. It is also used for diagnostic testing."

Answered by AI

Is Decadron a steroid?

"Steroids like dexamethasone help to prevent the release of substances in the body that cause inflammation. Dexamethasone is used to treat many conditions such as allergies, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, and breathing disorders."

Answered by AI

What is in a Decadron shot?

"This medication is used to treat a variety of conditions, including arthritis, blood/hormone disorders, allergic reactions, skin diseases, eye problems, breathing problems, bowel disorders, cancer, and immune system disorders."

Answered by AI

What are the side effects of dexamethasone?

"The possible side effects of the medication are an upset stomach, stomach irritation, vomiting, headache, dizziness, insomnia, restlessness, and depression."

Answered by AI

Clinical Trials for Hexadrol

Image of Helix Biomedics, LLC Site Number : 8400005 in Boynton Beach, United States.

Have you considered Hexadrol clinical trials? We made a collection of clinical trials featuring Hexadrol, we think they might fit your search criteria.

Image of University of Vermont Medical Center in Burlington, United States.

Exercise Program for Asthma

18+

All Sexes

Burlington, VT

This trial will study the use of a remote digital exercise program called Vitala in adults with obesity and poorly controlled asthma. The main goal is to see if participants find the program feasible and acceptable by completing

Waitlist Available

Has No Placebo

University of Vermont Medical Center

Image of University of Pennsylvania in Philadelphia, United States.

Self-Help Interventions for Crohn's Disease

18+

All Sexes

Philadelphia, PA

This trial is looking at different ways to help patients with moderate-to-severe IBD improve their ability to manage their condition and reduce disability. Participants will receive four different self-help resources for free - a

Waitlist Available

Has No Placebo

University of Pennsylvania

Image of Research Site in Tallahassee, United States.

Inhaled PT007 for Asthma

18 - 65

All Sexes

Tallahassee, FL

"This trial will test the effectiveness and safety of inhaled PT007 in treating asthma compared to a placebo and another asthma medication. The study will involve male and female participants aged 18 to 65 and

Phase 2

Waitlist Available

Senior-friendly

Research Site (+2 Sites)AstraZeneca

Image of Orange County Research Center in Lake Forest, United States.

AMG 691 for Asthma

18 - 65

All Sexes

Lake Forest, CA

This trial aims to test the safety and how well participants can tolerate a new drug called AMG 691. The study will involve giving single doses of the drug to healthy participants and both single and multiple

Phase 1

Recruiting

Paid Trial

Orange County Research Center (+1 Sites)MDAmgen

Have you considered Hexadrol clinical trials? We made a collection of clinical trials featuring Hexadrol, we think they might fit your search criteria.

Image of Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham in Birmingham, United States.

AI-Based Screening for Glaucoma

18+

All Sexes

Birmingham, AL

This trial aims to see if implementing an eye screening program at health centers can help detect eye conditions like glaucoma, diabetic retinopathy, and cataracts. They will use an artificial intelligence

Waitlist Available

Has No Placebo

Department of Ophthalmology and Visual Sciences, University of Alabama at BirminghamCynthia Owsley, PhD

Image of Solarea Bio Inc in Waltham, United States.

Probiotic Medical Food for Healthy Adults

18 - 64

All Sexes

Waltham, MA

"This trial will test a new medical food product made of probiotics and prebiotics on healthy volunteers. They will take either SBD111 or SBD121 for seven days, and researchers will measure

Recruiting

Has No Placebo

Solarea Bio IncAlicia E Ballok, PhDSolarea Bio, Inc

Image of Albert Einstein College of Medicine in Bronx, United States.

Perception Training for Asthma

18+

All Sexes

Bronx, NY

This trial aims to help older adults with uncontrolled asthma by training them to better perceive airway obstruction and improve their asthma self-management behaviors. The intervention involves feedback through peak expiratory flow prediction and

Recruiting

Behavior

Albert Einstein College of Medicine (+1 Sites)Juan Wisnivesky, MD, DrPH

Image of OK Clinical Research, LLC Site Number : 8400021 in Edmond, United States.

Lunsekimig for Asthma

18+

All Sexes

Edmond, OK

This trial will assess the long-term safety and effectiveness of a medication called lunsekimig in adults with moderate-to-severe asthma. Participants who finished the initial study will have the option to join this

Phase 2

Recruiting

Has No Placebo

OK Clinical Research, LLC Site Number : 8400021Sanofi

Have you considered Hexadrol clinical trials? We made a collection of clinical trials featuring Hexadrol, we think they might fit your search criteria.