Hexadrol

Pemphigus, Macular Edema, Iridocyclitis + 102 more

Treatment

106 FDA approvals

20 Active Studies for Hexadrol

Treatment for

Pemphigus

What is Hexadrol

DexamethasoneThe Generic name of this drug

Treatment SummaryDexamethasone (MK-125) is a type of steroid that was developed in 1957 and approved by the FDA in 1958. It is used to treat a wide range of conditions, including endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and others. In 2020, a clinical trial recommended the use of dexamethasone for COVID-19 patients with severe respiratory symptoms, as it was found to reduce deaths by one third in those requiring ventilation and by one fifth in those requiring oxygen.

Decadronis the brand name

image of different drug pills on a surface

Hexadrol Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Decadron

Dexamethasone

1958

452

Approved as Treatment by the FDA

Dexamethasone, also known as Decadron, is approved by the FDA for 106 uses which include Drug Allergy and anterior eye segment inflammation .

Drug Allergy

Helps manage Drug hypersensitivity reaction

anterior eye segment inflammation

Helps manage anterior eye segment inflammation

Trialled at least two prior therapies including lenalidomide and a proteasome inhibitor

Used to treat Trialled at least two prior therapies including lenalidomide and a proteasome inhibitor in combination with Isatuximab

Seborrheic dermatitis

Helps manage Severe Seborrheic Dermatitis

Berylliosis

Helps manage Berylliosis

Iridocyclitis

Helps manage Iridocyclitis

Ankylosing Spondylitis

Helps manage Ankylosing Spondylitis (AS)

Immune Thrombocytopenia (ITP)

Helps manage Immune Thrombocytopenia (ITP)

Regional Enteritis

Helps manage Regional Enteritis

Optic Neuritis

Helps manage Optic Neuritis

Lymphoma, Non-Hodgkin

Helps manage Malignant Lymphomas

Crohn Disease

Helps manage Regional Enteritis

Lupus

Helps manage Systemic Lupus Erythematosus (SLE)

severe Psoriasis

Helps manage severe Psoriasis

Multiple Myeloma

Used to treat Multiple Myeloma (MM) in combination with Isatuximab

Rhinitis, Allergic

Helps manage Perennial Allergic Rhinitis (PAR)

Hay Fever

Helps manage Seasonal Allergic Rhinitis

Choroiditis

Helps manage Choroiditis

Hypercalcemia

Helps manage Hypercalcemia

Synovitis

Helps manage Synovitis

Mycosis Fungoides

Helps manage Mycosis Fungoides (MF)

Conjunctivitis

Helps manage anterior eye segment inflammation

Tennis Elbow

Helps manage Epicondylitis

Arthritis, Gouty

Helps manage Acute Gouty Arthritis

Degenerative polyarthritis

Helps manage Posttraumatic Osteoarthritis

Bursitis

Helps manage Bursitis

Cushing Syndrome

Anemia, Hemolytic

Helps manage acquired immune hemolytic anemia

Optic Neuritis

Helps manage Optic Neuritis

Congenital adrenal hyperplasia

Helps manage Congenital Adrenal Hyperplasia (CAH)

Adrenocortical Hyperfunction

Bursitis

Helps manage Bursitis

Ulcerative Colitis

Helps manage Ulcerative Colitis

Asthma

Helps manage Asthma

Multiple Myeloma (MM)

Used to treat Multiple Myeloma (MM) in combination with Isatuximab

Uveitis

Helps manage Uveitis

Tuberculosis (TB)

Helps manage Tuberculosis (TB)

Mycosis Fungoides (MF)

Helps manage Mycosis Fungoides (MF)

Inflammation

Systemic Lupus Erythematosus (SLE)

Helps manage Systemic Lupus Erythematosus (SLE)

Edema of the cerebrum

Helps manage Edema of the cerebrum

Adrenal Insufficiency

Helps manage Adrenal cortical hypofunctions

Rheumatoid Arthritis

Helps manage Rheumatoid Arthritis

Secondary thrombocytopenia

Helps manage Secondary thrombocytopenia

Sarcoidosis

Helps manage Sarcoidosis

Ophthalmia, Sympathetic

Helps manage Ophthalmia, Sympathetic

Contact Dermatitis

Helps manage Contact Dermatitis

Rheumatoid Arthritis, Juvenile

Helps manage Rheumatoid Arthritis, Juvenile

Acute Leukemia (Category)

Helps manage Acute Leukemia (Category)

Acute Coryza

Helps manage acute rheumatic carditis

Choroiditis

Helps manage Choroiditis

Tenosynovitis

Helps manage Tenosynovitis

Epicondylitis

Helps manage Epicondylitis

Tuberculosis

Helps manage Tuberculosis (TB)

Loeffler's syndrome

Helps manage Loeffler's syndrome

Pemphigus

Helps manage Pemphigus

Synovitis

Helps manage Synovitis

Uveitis

Helps manage Uveitis

Chorioretinitis

Helps manage Chorioretinitis

non-suppurative Thyroiditis

Helps manage non-suppurative Thyroiditis

Atopic Dermatitis

Helps manage Atopic Dermatitis

Iritis

Helps manage Iritis

Congenital Hypoplastic Anemia

Helps manage Congenital Hypoplastic Anemia

Aspiration Pneumonitis

Helps manage Aspiration Pneumonitis

Acute Gouty Arthritis

Helps manage Acute Gouty Arthritis

Posttraumatic Osteoarthritis

Helps manage Posttraumatic Osteoarthritis

Hypercalcemia

Helps manage Hypercalcemia

Asthma

Helps manage Asthma

Rosacea

Helps manage Rosacea

Cancer

Helps manage Cancer

Trichinosis

Helps manage Trichinosis

Erythroblastopenia

Helps manage Erythroblastopenia

Keratitis

Helps manage Keratitis

Adrenal Gland Hyperfunction

Drug hypersensitivity reaction

Helps manage Drug hypersensitivity reaction

Brain

Helps manage Edema of the cerebrum

Seasonal Allergic Rhinitis

Helps manage Seasonal Allergic Rhinitis

Adrenal cortical hypofunctions

Helps manage Adrenal cortical hypofunctions

Perennial Allergic Rhinitis (PAR)

Helps manage Perennial Allergic Rhinitis (PAR)

Inflammation

Severe Seborrheic Dermatitis

Helps manage Severe Seborrheic Dermatitis

exfoliative erythroderma

Helps manage exfoliative erythroderma

Iridocyclitis

Helps manage Iridocyclitis

Stevens-Johnson Syndrome

Helps manage Stevens-Johnson Syndrome

Berylliosis

Helps manage Berylliosis

acquired immune hemolytic anemia

Helps manage acquired immune hemolytic anemia

Cushing's Syndrome

Ankylosing Spondylitis (AS)

Helps manage Ankylosing Spondylitis (AS)

Malignant Lymphomas

Helps manage Malignant Lymphomas

Serum Sickness

Helps manage Serum Sickness

Congenital Adrenal Hyperplasia (CAH)

Helps manage Congenital Adrenal Hyperplasia (CAH)

Ulcerative Colitis

Helps manage Ulcerative Colitis

Iritis

Helps manage Iritis

Pulmonary Eosinophilia

Helps manage Loeffler's syndrome

Allergic Conjunctivitis (AC)

Helps manage Allergic Conjunctivitis (AC)

Anemia, Diamond-Blackfan

Helps manage Congenital Hypoplastic Anemia

Arthritis, Juvenile

Helps manage Rheumatoid Arthritis, Juvenile

Acute Myeloid Leukemia (AML)

Helps manage Acute Leukemia (Category)

varicella-zoster virus acute retinal necrosis

Helps manage varicella-zoster virus acute retinal necrosis

Rosacea

Helps manage Rosacea

Multiple Myeloma

Used to treat Trialled at least two prior therapies including lenalidomide and a proteasome inhibitor in combination with Isatuximab

Bullous dermatitis herpetiformis

Helps manage Bullous dermatitis herpetiformis

Thrombocytopenia

Helps manage Secondary thrombocytopenia

Pemphigus

Helps manage Pemphigus

Thyroiditis

Helps manage non-suppurative Thyroiditis

Psoriasis

Helps manage severe Psoriasis

Effectiveness

How Hexadrol Affects PatientsCorticosteroids are drugs that reduce inflammation by blocking certain signals from being sent to the body. The amount of time these drugs stay in the body depends on how they are taken. As the amount of corticosteroids people need to take is usually more than what their bodies naturally produce, they have a wide therapeutic window. It is important to warn people taking corticosteroids that they are at risk for their body's natural hormone system being suppressed and for getting infections more easily.

How Hexadrol works in the bodyCorticosteroids reduce inflammation in the body by decreasing the activity of certain proteins and genes. This helps to shrink blood vessels and reduce the number of white blood cells going to the site of inflammation. Low doses of corticosteroids work to reduce inflammation and high doses can suppress your immune system. Taking glucocorticoids over a long period of time can cause an increase in sodium levels and a decrease in potassium levels.

When to interrupt dosage

The measure of Hexadrol is based upon the diagnosed ailment, like Pink Eye, Brain and Keloids Scars. The degree of dosage also depends on the technique of delivery as detailed in the table below.

Condition

Dosage

Administration

Iritis

, 0.7 mg, 0.001 mg/mg, 10.0 mg/mL, 4.0 mg/mL, 1.5 mg, 1.0 mg/mL, 4.0 mg, 0.75 mg, 1.0 mg, 2.0 mg, 6.0 mg, 0.5 mg, 0.5 mg/mL, 0.1 %, 40.0 mg, 0.0005 mg/mg, 517.0 mg/mL, 0.0015 mg/mg, 0.4 mg, 20.0 mg, 0.1 mg/mL, 0.5 mg/units

, Implant, Implant - Intravitreal, Intravitreal, Ointment, Ointment - Ophthalmic, Ophthalmic, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution, Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Injection, solution - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Suspension / drops, Solution, Solution - Ophthalmic, Auricular (otic), Suspension - Auricular (otic), Intramuscular, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Injection, Intra-articular; Intramuscular; Intravenous, Injection - Intramuscular; Intravenous, Elixir, Elixir - Oral, Liquid, Liquid - Intramuscular; Intravenous, Intramuscular; Intrasynovial; Intravenous, Liquid - Intramuscular; Intrasynovial; Intravenous, Liquid - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Auricular (otic); Ophthalmic, Solution / drops - Auricular (otic); Ophthalmic, Solution - Intramuscular; Intrasynovial; Intravenous, Solution - Auricular (otic); Ophthalmic, Solution - Intra-articular; Intramuscular; Intravenous, Topical, Solution / drops - Topical, Ophthalmic; Topical, Liquid - Ophthalmic; Topical, Ointment - Topical, Liquid - Auricular (otic); Ophthalmic, Ointment - Auricular (otic); Ophthalmic, Solution - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Solution - Intramuscular; Intravenous, Liquid - Intra-articular; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Oral, Solution - Oral, Suspension / drops - Auricular (otic), Injection - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Dental, Liquid - Dental, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Epidural; Infiltration; Intramuscular; Intravenous, Injection - Intramuscular, Solution - Parenteral, Parenteral, Injection, solution - Ophthalmic, Intraocular, Injection, solution - Intraocular, Injection, suspension, Injection, suspension - Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, suspension - Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue, Intramuscular; Intravenous; Topical, Kit - Intramuscular; Intravenous; Topical, Injection, emulsion, Injection, emulsion - Intramuscular; Intravenous, Insert, Insert - Ophthalmic, Solution - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Perineural, Suspension / drops - Topical

Seborrheic dermatitis

Necrobiosis Lipoidica

Bursitis

Skin Diseases

Rosacea

Branch Retinal Vein Occlusion

Eye Infections

Multiple Myeloma

Otitis Externa

Ankylosing Spondylitis

Otitis Externa

Lichen Planus

Ocular Itching

Mycosis Fungoides

Sarcoidosis

Otitis Media

Erythroblastopenia

Hay Fever

Tympanostomy tube insertion

Warnings

Hexadrol has nineteen contraindications, so it should be avoided for the conditions presented in the following table.Hexadrol Contraindications

Condition

Risk Level

Notes

active periocular infections

Do Not Combine

Eye

Do Not Combine

Tympanic membrane structure

Do Not Combine

suspected periocular infections

Do Not Combine

Eye Infections, Fungal

Do Not Combine

Viral Conjunctivitis

Do Not Combine

Communicable Diseases

Do Not Combine

Eye Infection

Do Not Combine

Mycoses

Do Not Combine

Chickenpox

Do Not Combine

External auditory canal structure

Do Not Combine

epithelial herpes simplex keratitis

Do Not Combine

External Ear

Do Not Combine

torn posterior lens

Do Not Combine

Open-angle glaucoma

Do Not Combine

Cornea

Do Not Combine

Eye Infections

Do Not Combine

ruptured posterior lens

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Dexamethasone may interact with Pulse Frequency

There are 20 known major drug interactions with Hexadrol.

Common Hexadrol Drug Interactions

Drug Name

Risk Level

Description

1,2-Benzodiazepine

Major

The metabolism of 1,2-Benzodiazepine can be increased when combined with Dexamethasone.

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Dexamethasone is combined with 2-Methoxyethanol.

3,5-diiodothyropropionic acid

Major

The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Dexamethasone.

6-O-benzylguanine

Major

The metabolism of 6-O-benzylguanine can be increased when combined with Dexamethasone.

7-ethyl-10-hydroxycamptothecin

Major

The metabolism of 7-ethyl-10-hydroxycamptothecin can be increased when combined with Dexamethasone.

Hexadrol Toxicity & Overdose RiskIn mice, the toxic dose of this drug taken orally is 6.5g/kg and intravenously is 794mg/kg. Taking too much of this drug over a long period of time can cause cataracts, glaucoma, high blood pressure, water retention, high cholesterol, ulcers, pancreatitis, muscle weakness, mood swings, psychosis, thinning of the skin, allergies, acne, increased body hair, reduced resistance to infections, facial swelling, high blood sugar, low calcium levels, low phosphorous levels, and slowed growth. If you think you’ve taken too much of this drug,

image of a doctor in a lab doing drug, clinical research

Hexadrol Novel Uses: Which Conditions Have a Clinical Trial Featuring Hexadrol?

345 active studies are currently underway to determine the potential of Hexadrol for handling Eye Infections, Stevens-Johnson Syndrome and Chorioretinitis.

Condition

Clinical Trials

Trial Phases

Acute Myeloid Leukemia (AML)

30 Actively Recruiting

Phase 1, Phase 2, Phase 3, Not Applicable

Asthma

86 Actively Recruiting

Phase 4, Early Phase 1, Not Applicable, Phase 2, Phase 3, Phase 1

Rheumatoid Arthritis

54 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1

Otitis Media

0 Actively Recruiting

Erythroblastopenia

0 Actively Recruiting

Psoriasis

0 Actively Recruiting

Bullous dermatitis herpetiformis

0 Actively Recruiting

Drug Allergy

0 Actively Recruiting

Eye Infections

0 Actively Recruiting

Arthritis, Gouty

0 Actively Recruiting

cutaneous dermatophyte infection

0 Actively Recruiting

Otitis

2 Actively Recruiting

Not Applicable

Allergic Conjunctivitis (AC)

2 Actively Recruiting

Phase 3

Eye

0 Actively Recruiting

Communicable Diseases

0 Actively Recruiting

Open-angle glaucoma

36 Actively Recruiting

Not Applicable, Phase 2, Phase 4, Early Phase 1, Phase 1

Lupus Erythematosus, Discoid

5 Actively Recruiting

Phase 2, Phase 3

Macular Edema

1 Actively Recruiting

Phase 2

Cataract Surgery

2 Actively Recruiting

Not Applicable, Phase 4

Ophthalmic Surgery

0 Actively Recruiting

Patient Q&A Section about hexadrol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Dexamethasone Sodium Phosphate injection used for?

"Dexamethasone injection is a medication used to treat severe allergic reactions, edema, gastrointestinal disease, and certain types of arthritis. It is also used for diagnostic testing."

Answered by AI

Is Decadron a steroid?

"Steroids like dexamethasone help to prevent the release of substances in the body that cause inflammation. Dexamethasone is used to treat many conditions such as allergies, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, and breathing disorders."

Answered by AI

What is in a Decadron shot?

"This medication is used to treat a variety of conditions, including arthritis, blood/hormone disorders, allergic reactions, skin diseases, eye problems, breathing problems, bowel disorders, cancer, and immune system disorders."

Answered by AI

What are the side effects of dexamethasone?

"The possible side effects of the medication are an upset stomach, stomach irritation, vomiting, headache, dizziness, insomnia, restlessness, and depression."

Answered by AI

Clinical Trials for Hexadrol

Image of Medical University of South Carolina in Charleston, United States.

Have you considered Hexadrol clinical trials? We made a collection of clinical trials featuring Hexadrol, we think they might fit your search criteria.

Image of University of Ottawa Heart Institute in Ottawa, Canada.

Vascepa for Community-Acquired Pneumonia

18+

All Sexes

Ottawa, Canada

This trial aims to see if a medication called Vascepa can reduce inflammation in the arteries of adults with Community-Acquired Pneumonia (CAP). Participants will either take Vascepa or

Phase 3

Waitlist Available

Drug

University of Ottawa Heart Institute

Image of Harbor UCLA Medical Center - Medicine - Infectious Diseases in Torrance, United States.

Optimized Beta-lactam Dosing for Bacterial Infections

18+

All Sexes

Torrance, CA

"This trial aims to compare different methods of assessing kidney function in critically ill adult patients with certain infections. The study will use Cystatin C and Cystatin C-based estimated Glomerular Filtr

Phase 4

Waitlist Available

Has No Placebo

Harbor UCLA Medical Center - Medicine - Infectious Diseases (+5 Sites)

Image of University of North Carolina at Chapel Hill in Chapel Hill, United States.

PREVAIL Model of Care for Rheumatoid Arthritis

18+

All Sexes

Chapel Hill, NC

"This trial aims to see if a new method of integrating rehabilitation into routine care for adults with rheumatoid arthritis is practical. The method involves using a screening tool, providing recommendations for exercise and rehabilitation to

Waitlist Available

Has No Placebo

University of North Carolina at Chapel HillLouise Thoma, DPT, PhD

Image of GSK Investigational Site in San Antonio, United States.

Inhaler Propellants for Asthma

18 - 45

All Sexes

San Antonio, TX

This trial aims to compare two different propellants, HFA-152a and HFA-134a, to see if they cause airways to tighten when used in inhalers. The goal

Phase 1

Waitlist Available

Has No Placebo

GSK Investigational SiteGlaxoSmithKline

Have you considered Hexadrol clinical trials? We made a collection of clinical trials featuring Hexadrol, we think they might fit your search criteria.

Image of Centre interdisciplinaire de recherche en réadaptation et intégration sociale (Cirris) in Québec, Canada.

Feedback Device for Shoulder Pain

18+

All Sexes

Québec, Canada

"This trial aims to assess a new wearable device that measures shoulder movements and muscle activity to help workers with shoulder pain. The device provides real-time feedback to help workers understand and adjust to the physical demands of

Waitlist Available

Has No Placebo

Centre interdisciplinaire de recherche en réadaptation et intégration sociale (Cirris)Philippe Meidinger, PT, PhD student, PT, PhD student

Image of University of Chicago in Chicago, United States.

Therapy De-escalation for Ulcerative Colitis

18 - 75

All Sexes

Chicago, IL

This trial aims to understand how to best treat people with ulcerative colitis. They will compare patients who are in remission and continue their medication to those who decrease or stop their medication. The goal

Waitlist Available

Has No Placebo

University of ChicagoDavid T Rubin, MD

Image of Byers Eye Institute at Stanford University in Palo Alto, United States.

Electrical Stimulation for Glaucoma

18+

All Sexes

Palo Alto, CA

This trial aims to test how well a treatment called transorbital alternating current stimulation (rtACS) using the EYETRONIC device works for patients with glaucoma.

Phase 1 & 2

Waitlist Available

No Cost For Treatment

Byers Eye Institute at Stanford UniversityJeffrey L Goldberg, MD PhD

Image of Helix Biomedics, LLC Site Number : 8400005 in Boynton Beach, United States.

Lunsekimig for Asthma

18 - 80

All Sexes

Boynton Beach, FL

This trial is testing a new medication called SC lunsekimig as an add-on therapy for asthma treatment. It will involve male and female participants with asthma who are not eligible for other biologic treatments

Phase 2

Recruiting

Drug

Helix Biomedics, LLC Site Number : 8400005 (+8 Sites)Sanofi

Have you considered Hexadrol clinical trials? We made a collection of clinical trials featuring Hexadrol, we think they might fit your search criteria.